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In-vivo antibody imaging for the detection of human tumors

  • David M. Goldenberg
  • Hildegard Goldenberg
  • Robert M. Sharkey
  • Robert E. Lee
  • Jo Ann Horowitz
  • Thomas C. Hall
  • Hans J. Hansen
Part of the Cancer Treatment and Research book series (CTAR, volume 51)

Abstract

Radionuclide imaging has become an important method in the detection and staging of neoplastic diseases. However, most nuclear imaging methods localize lesions by indirectly demonstrating a decrease in the accretion of the radiopharmaceutical (negative image) or by a physiologic attribute of the tissue that permits a positive image of the lesion. For example, to the extent that a tumor lacks organ-specific properties, an organ-imaging agent could be used to show the tumor as a defect, such as with technetium sulfur colloid for imaging the liver and spleen. The development of more selective methods for localizing tumors by means of anti-cancer antibodies labeled with a radionuclide suitable for external imaging has been a recent approach gaining in interest and application for cancer imaging, although it has been pursued for over 30 years [1–3]. Early animal studies in the 1950s showed that radio-iodinated antibodies prepared against extracts of rodent tumors could localize in these tumors selectively [1,4,5]. Subsequently, it was found that this preferential tumor accretion of the radioactive antibodies was due mainly to anti-fibrin antibodies [1,6–8]; anti-fibrinogen antibodies were later explored for tumor imaging and therapy [1,9].

Keywords

Carcinoembryonic Antigen Antibody Fragment Prostatic Acid Phosphatase Antibody Imaging Magnetic Resonance Imagine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • David M. Goldenberg
  • Hildegard Goldenberg
  • Robert M. Sharkey
  • Robert E. Lee
  • Jo Ann Horowitz
  • Thomas C. Hall
  • Hans J. Hansen

There are no affiliations available

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