Structure-Activity Relationships of MDMA and Related Compounds: A New Class of Psychoactive Agents?
It has been hypothesized that MDMA and substances that possess a psychopharmacological effect similar to MDMA are members of a novel pharmacological class named entactogens [1–3]. In this chapter evidence will be presented to support this, through a discussion of the data acquired in efforts directed toward testing this hypothesis. Although these studies are far from complete, the results gathered thus far, together with those from other laboratories, support the view that the pharmacology of entactogens is clearly different from other known classes of compounds.
KeywordsDiscriminative Stimulus Drug Discrimination Training Dose Complete Substitution Discriminative Stimulus Property
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- 3.Oberlender. R and Nichob. D.E., 1988 Drug discrimination studies with MDMA and amphetamine. Psychophatmacology 95: 71–76.Google Scholar
- 4.Jaffe. J.H., 1985. Drug addiction and drug abuse. In The Pharmacological Basis of Therapeutics, Seventh Edition. (Gilnun. A G., Goodman. L.S., Rail. T.W. Murad. F. cds). New York. MacmilLan Publishing Company, pp. 523–581Google Scholar
- 5.Werner. N., 1980. Norepinephrine, epinephrine, and the sypalhominietic amines. In The Pharmacological Basis of Therapeutics, Sixth Edition, ( Gilrnan, A.G., Gooiman. L.S. and Gilman. A., cds.) New York: Macmillan. pp 138–175Google Scholar
- 6.Greer. G. and Tolbcrt. R., 1986 Subjective reports of the effects of MDMA in a clinical setting. J. Psychoactive Drugs 18: 319–327.Google Scholar
- 9.Overton. D.A., (1984). State dependent learning and drug discrimuiatioits In HanJkodt of PyHhopharmHelegy. Vol. 18 (lvcrsen. L.L., Ivcrscn. S.D and Snyder. S.H.cds.) New York: Plenum Press, pp. 59–126Google Scholar
- 10.Weil. A., 1976 The love drug. J. Psychoactive Drugs 8: 335–337Google Scholar
- 11.Turek. I S., Soskiri. R A. and Kurland. A A., 1974 Meihyleitedioxyamphctainine (MDA) Subjective effects J Psychedelic Dnigs 6:7–14128 7. Structure-Activity Relationships of MDMA and Related CompoundsGoogle Scholar
- 14.Glctinon. R.A. and Young. R., 19R4. MDA: An agent that produces stimulus effects similar to those of 3.4-DMA. LSD and cocaine. Fair. J. Pharmacol. 99: 249–250.Google Scholar
- 15.Glennon. R.A and Young. R., 1984. MDA: A psychoactive agent with dual stimulus effects. Life So. 34: 379–383Google Scholar
- 16.Shulgui. A.T., 1978. Psychotomimetic drugs Structure-activity relationships. In Handbook of Psychopharmacology. Vol 11 (lversen, L.L., lversen, S I), and Snyder. S.H., eds.). New York: Plenum, pp. 243–333.Google Scholar