Structure-Activity Relationships of MDMA and Related Compounds: A New Class of Psychoactive Agents?

  • David F. Nichols
  • Robert Oberlender
Part of the Topics in the Neurosciences book series (TNSC, volume 9)


It has been hypothesized that MDMA and substances that possess a psychopharmacological effect similar to MDMA are members of a novel pharmacological class named entactogens [1–3]. In this chapter evidence will be presented to support this, through a discussion of the data acquired in efforts directed toward testing this hypothesis. Although these studies are far from complete, the results gathered thus far, together with those from other laboratories, support the view that the pharmacology of entactogens is clearly different from other known classes of compounds.


Discriminative Stimulus Drug Discrimination Training Dose Complete Substitution Discriminative Stimulus Property 
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© Kluwer Academic Publishers 1990

Authors and Affiliations

  • David F. Nichols
  • Robert Oberlender

There are no affiliations available

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