Bcl-2 family proteins and the regulation of programmed cell death in leukemia and lymphoma

  • John C. Reed
  • Toshiyuki Miyashita
  • Stanislaw Krajewski
  • Shinichi Takayama
  • Christine Aime-Sempe
  • Shinichi Kitada
  • Takaaki Sato
  • Hong-Gang Wang
  • Masayoshi Harigai
  • Motoi Hanada
  • Maryla Krajewska
  • Kristine Kochel
  • Juan Millan
  • Hiroko Kobayashi
Chapter
Part of the Cancer Treatment and Research book series (CTAR, volume 84)

Abstract

Members of the bcl-2 gene family play a central role in regulating the relative sensitivity and resistance of cells to a wide variety of apoptotic stimuli. The first member of this multigene family ,bcl-2, was discovered by virtue of its involvement in the t(14;18) chromosomal translocations commonly found in non-Hodgkin’s lymphomas [1–4]. Deregulation of the bcl-2 gene either by translocations in B-cell lymphomas or through other mechanisms in several other types of cancer, including acute and chronic leukemias, contributes to neoplastic cell expansion by prolonging cell survival rather than by accelerating rates of cell division [5–8]. The Bcl-2 protein also can protect tumor cells from apoptosis induced by radiation and nearly all cytotoxic anticancer drugs [9–12], thus potentially contributing to treatment failures in patients with cancer [13–16]. Several additional homologues of bcl-2 have recently been discovered in humans and other mammals, revealing the presence of a multigene family [17–20]. Moreover, homologues of bcl-2 have been discovered in some DNA viruses, including Epstein-Barr virus (EBV), which plays a significant role in the pathogenesis of some types of non-Hodgkin’s lymphomas and Hodgkin’s disease [21]. Interestingly, some members of the bcl-2 gene family function as inhibitors of cell death, similar to bcl-2, whereas others are promoters of apoptosis that oppose the actions of the Bcl-2 protein.

Keywords

Follicular Lymphoma Germinal Center African Swine Fever Virus Gene Transfer Study 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Kluwer Academic Publishers, Boston 1996

Authors and Affiliations

  • John C. Reed
  • Toshiyuki Miyashita
  • Stanislaw Krajewski
  • Shinichi Takayama
  • Christine Aime-Sempe
  • Shinichi Kitada
  • Takaaki Sato
  • Hong-Gang Wang
  • Masayoshi Harigai
  • Motoi Hanada
  • Maryla Krajewska
  • Kristine Kochel
  • Juan Millan
  • Hiroko Kobayashi

There are no affiliations available

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