Pharmacokinetics of the peritoneal-plasma barrier after systemic mitomycin C administration
Intraperitoneal administration of drugs continues to be of considerable interest for regional and systemic drug delivery in both animals and humans. There have been extensive studies, notably by Lukas et al.  and Torres et al. , to determine the pharmacokinetics involved in the transport of drugs from the peritoneal cavity into the portal and systemic circulation. In recent years, interest in the exchange of substances between the peritoneal cavity and the systemic circulation has been focused on humans. This has been stimulated in large part by the utilization of chronic peritoneal dialysis for patients in renal failure. Also, the peritoneal cavity is an important site for the spread of cancer from gastrointestinal and ovarian tumors. Controversy currently exists regarding the use of intraperitoneal chemotherapy to optimize the management of cancers that involve the peritoneal surfaces. Investigations of the pharmacokinetics involved during the transport of drugs from the peritoneum into the blood gave birth to the pharmacologic entity known as the peritoneal-plasma barrier (PPB) [3–7].
Unable to display preview. Download preview PDF.
- 4.Dedrick RL, Meyers CE, Bungay PM, DeVita VT, Jr. Pharmacokinetics rationale for peritoneal drug administration in the treatment of ovarian cancer. Cancer Treat Rep 1978;162:1–11.Google Scholar
- 9.Sugarbaker PH, Cunliffe W, Belliveau J, et al. Rationale for early postoperative intra-peritoneal chemotherapy as a surgical adjuvant for gastrointestinal malignancy. Reg Cancer Treat 1989;1:66–79.Google Scholar
- 10.Sugarbaker PH. Cytoreductive approach to peritoneal carcinomatosis: Peritonectomy and intraperitoneal chemotherapy. In Postgraduate Advances in Colorectal Surgery. ••: Forum Medicum, 1991, pp II-X.Google Scholar
- 11.Sugarbaker PH. Peritonectomy procedures. Ann Surg, in press.Google Scholar
- 12.Vidal-Jove J, Pessagno AM, Esquivei J, Buck DR, Steves MA, Sugarbaker PH. Technical aspect and morbidity assessment of intraperitoneal chemotherapy administered by repeated paracentesis. Reg Cancer Treat 1992;4:294–297.Google Scholar
- 18.Den Hartigh J, McVie JG, Van Oort WJ, Pinedo HM. Pharmacokinetics of mitomycin C in humans. Cancer Res 1983;43:5017–5021.Google Scholar
- 20.Dedrick RL, Flessner MF, Collins JM, Schultz JS. Is the peritoneum a membrane? Am Soc Artif Intern Organs J 1982;5:1–8.Google Scholar