Structure and Expression of Fc Receptors (FcR)

  • Catherine Sautès


Different classes of cell surface receptors have the ability to interact with the Fc domain of Ig. The largest and most extensively characterized group are the FcR which belong to the immunoglobulin su-pergene family. These include receptors mediating major functions of the immune system and immunoglobulin transporters, exemplified by the poly-immunoglobulin receptor for IgM and IgA, and the IgG transporter of neonatal gut, recently characterized at the three-dimensional structure level. Some other FcR are lectin like molecules such as the low affinity receptor for IgE.


Cytoplasmic Tail Transmembrane Region Extracellular Region Complement Receptor Type Intracytoplasmic Tail 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Anderson C, Looney R. Review: human leukocyte IgG Fc receptors. Immunol Today 1986; 7:264–266.CrossRefGoogle Scholar
  2. 2.
    Unkeless JC, Scigliano E, Freedman V. Structure and function of human and murine receptors for IgG. Annu Rev Immunol 1988; 6:251–281.PubMedCrossRefGoogle Scholar
  3. 3.
    Ravetch J, Kinet J. Fc Receptors. Annu Rev Immunol 1991; 9:457–492.PubMedCrossRefGoogle Scholar
  4. 4.
    Fridman WH, Bonnerot C, Daëron M et al. Structural bases of Feγ receptor functions. Immunol Rev 1992; 125:49–76.PubMedCrossRefGoogle Scholar
  5. 5.
    van de Winkel J, Capel P. Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications. Immunol Today 1993; 14:215–221.PubMedCrossRefGoogle Scholar
  6. 6.
    Daëron M, Sautès C, Bonnerot C et al. Murine type II Feγ receptors and IgG-Binding Factors. Chem. Immunol 1989; 47:21–78.PubMedCrossRefGoogle Scholar
  7. 7.
    Hulett MD, Hogarth MP. Molecular basis of the Fc receptor function. Adv Immunol 1994; 57:1–127.PubMedCrossRefGoogle Scholar
  8. 8.
    Paquette R, Minosa M, Verma M et al. An interferon gamma-activation sequence mediates the transcriptional regulation of the IgG Fc receptor type IC gene by interferon-gamma. Mo. Immunol 1995; 32:841–851.CrossRefGoogle Scholar
  9. 9.
    Esposito-Farèse ME, Sautès C, de la Salle H et al. Membrane and soluble FcγRII/III modulate the antigen presenting capacity of murine dendritic epidermal Langerhans cells for IgG-complexed antigens. J Immunol 1995; 155:1725–1736.PubMedGoogle Scholar
  10. 10.
    Latour S, Fridman WH, Daëron M. Identification, molecular cloning, biological properties and tissue distribution of a novel isoform of murine low-affinity IgG Receptor homologous to human FcγRIIBl. J Immunol 1996; in press.Google Scholar
  11. 11.
    Tartour E, de la Salle H, de la Salle C et al. Identification, in mouse macrophages and in serum, of a soluble receptor for the Fc portion of IgG (FcγR) encoded by an alternatively spliced transcript of the FcγRII gene. Intern. Immunol 1993; 5:859–868.CrossRefGoogle Scholar
  12. 12.
    Hsieh H, Thompson N. Dissociation Kinetics between a Mouse Fc receptor (FcγRII) and IgG: Measurement by total internal reflection with fluorescence photobleaching recovery. Biochemistry 1995; 34:12481–12488.PubMedCrossRefGoogle Scholar
  13. 13.
    Daëron M, Yodoi J, Néauport-Sautès C et al. Receptors for Immunoglobulin Isotypes (FcR) on murine T cells. I. Multiple FcR on T lymphocytes and hybridoma T lymphocytes and hybridoma T cell clones. Eur J Immunol 1985; 15:662–667.PubMedCrossRefGoogle Scholar
  14. 14.
    Löwy I, Brézin C, Néauport-Sautès C et al. Isotype regulation of antibody production: T cell hybrids can be selectively induced to produce subclass specific suppressive Immunoglobulin-Binding Factors. Proc Natl Acad Sci USA 1983; 80:2323–2327.PubMedCrossRefGoogle Scholar
  15. 15.
    Fridman WH, Gresser I, Bandu MT et al. Interferon enhances the expression of Fcγ receptors. J Immunol 1980; 124:2436–2441.PubMedGoogle Scholar
  16. 16.
    Weinshank RL, Luster AD, Ravetch JV. Function and regulation of a murine macrophage-specific IgG Fc receptor, FcγR-α. J Exp Med 1988; 167:1909–1925.PubMedCrossRefGoogle Scholar
  17. 17.
    Conrad DH, Waldschmidt TJ, Lee WT et al. Effect of B cell stimulatory factor-1 (interleukin 4) of Fcε and Fcγ receptor expression on murine B lymphocytes and B cell lines. J Immunol 1987; 139:2290–2296.PubMedGoogle Scholar
  18. 18.
    Astier A, de la Salle H, de la Salle C et al. Human epidermal Langerhans cells secrete a soluble receptor for IgG (FcγRII/CD32) that inhibits the binding of immune-complexes to FcγR+ cells. J Immunol 1994; 152:201–212.PubMedGoogle Scholar
  19. 19.
    Masuda M, Roos D. Association of all three types of FcγR (CD64, CD32, CD16) with a γ chain homodimer in cultured human monocytes. J Immunol 1993; 151:6382–6388.PubMedGoogle Scholar
  20. 20.
    Schmidt D, Hanau D, Bieber T et al. Human epidermal Langerhans cells express only the 40-kilodalton Fcγ receptor (FcRII). J Immunol 1990; 144:4284.Google Scholar
  21. 21.
    Cassel DL, Keller MA, Surrey S et al. Differential expression of FcγRIIA, FcγRIIB and FcγRIIC in hematopoietic cells: analysis of transcripts. Mol Immunol 1993; 30:451–460.PubMedCrossRefGoogle Scholar
  22. 22.
    Metes D, Galatiuc C, Moldovan I et al. Expression and function of FcγRII on human natural killer cells. Nat Immun 1994; 13:289–300.PubMedGoogle Scholar
  23. 23.
    Sarmay G, Rozsnyay Z, Koncz G et al. The alternative splicing of human FcγRII mRNA is regulated by activation of B cells with mIgM cross-linking, interleukin-4, or phorbolester. Eur J Immunol 1995; 25:262–268.PubMedCrossRefGoogle Scholar
  24. 24.
    Galon J, Bouchard C, Fridman WH et al. Ligands and biological activities of soluble Fcγ receptors. Immunol Letters 1995; 44:175–181.CrossRefGoogle Scholar
  25. 25.
    Galon J, Gauchat JF, Mazières N et al. Soluble Fcγ Receptor type III (FcγRIII, CD16) triggers cell activation through interaction with complement receptors. J Immunol 1996; 107:1184–1192.Google Scholar
  26. 26.
    Kurosaki T, Gander I, Wirthmueller U et al. The β subunit of the FcεRI Is associated with the FcγRIII on mast cells. J Exp Med 1992; 175:447–460.PubMedCrossRefGoogle Scholar
  27. 27.
    Edberg CJ, Barinsky M, Redecha PB et al. FcRIII expressed on cultured monocytes is a N-glycosylated transmembrane protein distinct from FcγRIII expressed on natural killer cells. J Immunol 1990; 144:4729.PubMedGoogle Scholar
  28. 28.
    Zhou M-J, Todd III RF, van de Winkel JGJ et al. Cocapping of the leukoadhesin molecules complement receptor type 3 and lymphocyte function-associated antigen-1 with Fcγ receptor III on human neutrophils. J Immunol 1993; 150:3030–3041.PubMedGoogle Scholar
  29. 29.
    Poo H, Krauss J, Mayo-Bond L et al. Interaction of Fc gamma receptor type HIB with complement receptor type 3 in fibroblast transfectants: evidence from lateral diffusion and resonance energy transfer studies. J Mol Biol 1995; 247:597–612.PubMedGoogle Scholar
  30. 30.
    Zhou M, Brown E. CR3 (Mac-1, alpha M beta 2, CD1l b/CD18) and Fc gamma RIII cooperate in generation of a neutrophil respiratory burst: requirement for Fc gamma RIII and tyrosine phosphorylation. J. Cell. Biol 1994; 125:1407.PubMedCrossRefGoogle Scholar
  31. 31.
    Petty HR, Todd III RF. Receptor-receptor interactions of complement receptor type 3 in neutrophil membranes. J Leuk Biol 1993; 54:492–494.Google Scholar
  32. 32.
    Stöckl J, Majdic O, Pickl A et al. Granulocyte activation via a binding site near the C-terminal region of complement receptor type 3 (α-chain (CD11b) potentially involved in intramembrane complex formation with glycosylphosphatidylinositol-anchored FcγRIIIB (CD16) molecules. J Immunol 1995; 154:5452.PubMedGoogle Scholar
  33. 33.
    Thornton B, Vetvicka V, Pitman M et al. Analysis of the sugar specificity and molecular location of the β-glucan-binding lectin site of complement receptor type 3 (CD11b/CD18). J Immunol 1996; 156:1235.PubMedGoogle Scholar
  34. 34.
    Gessner JE, Grussenmeyer T, Kolanus W et al. The human low affinity immunoglobulin G Fc Receptor III-A and III-B genes. J Biol Chem 1995; 270:1350–1361.PubMedCrossRefGoogle Scholar
  35. 35.
    Li M, Wirthmueller U, Ravetch JV. Reconstitution of human FcγRIII cell type specificity in transgenic mice. J. Exp. Med 1996; 183:1259–1263.PubMedCrossRefGoogle Scholar
  36. 36.
    Tamm A, Kister A, Nolte KU et al. The IgG binding site of human FcγRIIIB receptor involves CC’ and FG loops of the membrane-proximal domain. J Biol Chem 1996; 271:1–8.Google Scholar
  37. 37.
    Hibbs M, Tolvanen M, Carpén O et al. Membrane-proximal Ig-like domain of FcγRIII (CD16) contains residues critical for ligand binding. J Immunol 1994; 152:4466–4474.PubMedGoogle Scholar
  38. 38.
    Metzger H, Alcaraz G, Hohman R et al. The receptor with high affinity for immunoglobulin E. Annu Rev Immunol 1986; 4:419–470.CrossRefGoogle Scholar
  39. 39.
    Kinet JP, Metzger H. Genes, structure, and actions of the high-affinity Fc receptor for Immunoglobulin E. In: Metzger H, ed. Fc receptors and the action of antibodies. ASM, Washington, USA 1990; 239–259.Google Scholar
  40. 40.
    Morton H, Van den Herik-Oudijk I, Vossebeld P. Functionnal association between the human myeloid IgA Fc receptor (CD89) and FcRγ chain. J Biol Chem 1995; 270:29781–29787.PubMedCrossRefGoogle Scholar
  41. 41.
    de Wit T, Morton H, Capel P et al. Structure of the gene for the human myeloid IgA Fc receptor (CD89). J Immunol 1995; 155:1201–1209.Google Scholar
  42. 42.
    Reterink TJ, Levarht EW, Klar-Mohamad N et al. Transforming growth factor-beta 1 (TGF-beta 1) downregulates IgA Fc-receptor (CD89) expression on human monocytes. Clin Exp Immunol 1996; 103:161–166.PubMedCrossRefGoogle Scholar
  43. 43.
    Burmeister W, Huber A, Bjorkman P. Crystal structure of the complex of rat neonatal Fc receptor with Fc. Nature 1994; 372:379–383.PubMedCrossRefGoogle Scholar
  44. 44.
    Burmeister WP, Gastinel LN, Simister NE et al. Crystal structure at 2.2 A resolution of the MHC-related neonatal Fc receptor. Nature 1994; 372:336–343.PubMedCrossRefGoogle Scholar
  45. 45.
    Blumberg R, Koss T, Story C et al. A major histocompatibility complex class I-related Fc receptor for IgG on rat hepatocytes. J Clin Invest 1995; 95:2397–2402.PubMedCrossRefGoogle Scholar
  46. 46.
    Conrad DH. FcεRII/CD23: The low affinity receptor for IgE. Annu Rev Immunol 1990; 8:623.PubMedCrossRefGoogle Scholar
  47. 47.
    Delespesse G, Suter U, Mossalayi D et al. Expression, structure and function of the CD23 antigen. Adv Immunol 1991; 49:149–191.PubMedCrossRefGoogle Scholar
  48. 48.
    Delespesse G, Sarfati M, Wu CY et al. The low affinity receptor for IgE. Immunol Rev 1992; 125:77–97.PubMedCrossRefGoogle Scholar
  49. 49.
    Bonnefoy J-Y, Lecoanet-Henchoz S, Aubry JP et al. CD23 and B cell activation. Current Opin Immunol 1995; 7:355–359.CrossRefGoogle Scholar
  50. 50.
    Beavil R, Graber P, Aubonney N et al. CD23/FcεRII and its soluble fragments can form oligomers on the cell surface and in solution. Immunology 1995; 84:202–206.PubMedGoogle Scholar
  51. 51.
    Aubry J-P, Pochon S, Graber P et al. CD21 is a ligand for CD23 and regulates IgE production. Nature 1992; 358:505–507.PubMedCrossRefGoogle Scholar
  52. 52.
    Lecoanet-Henchoz S, Gauchat J, Aubry J et al. CD23 regulates monocyte activation through a novel interaction with the adhesion molecules CD11b-CD18 and CDllc-CD18. Immunity 1995; 3:119–125.PubMedCrossRefGoogle Scholar
  53. 53.
    Beavil A, Edmeades R, Gould H et al. α-Helical coiled-coil stalks in the low-affinity receptor for IgE (FcεRII/CD23) and related C-type lectins. Proc Nad Acad Sci USA 1992; 89:753–760.CrossRefGoogle Scholar
  54. 54.
    Dierks S, Bartlett W, Edmeades R et al. The oligomeric nature of the murine FcεRII/CD23: Implication for function. J Immunol 1993; 150:2372.Google Scholar
  55. 55.
    Bartlett WC, Kelly A, Johnson C et al. Analysis of murine soluble FcεRII sites of cleavage and requirements for dual-affinity interaction with IgE. J Immunol 1995; 154:4240–4246.PubMedGoogle Scholar
  56. 56.
    Waldschmidt TJ, Conrad DH, Lynch RG. The expression of B cell surface receptors.I. The ontogeny and distribution of the murine B cell IgE Fc receptor. J Immunol 1988; 140:2148–2154.PubMedGoogle Scholar
  57. 57.
    Mathur A, Lynch R, Köhler G. The contribution of constant region domains to the binding of murine IgM to Fcµ A receptors. J Immunol 1988; 140:143.PubMedGoogle Scholar
  58. 58.
    Waldschmidt TJ, Conrad DH, Lynch RG. The expression of B cell surface receptors.II. Interleukin 4 can accelerate the developmental expression of the murine B cell IgE Fc receptor. J Immunol 1989; 143: 2820–2827.PubMedGoogle Scholar
  59. 59.
    Hashimoto S, Koh K, Tomita Y et al. TNF-α regulates IL-4 induced FcεRII/CD23 gene expression and soluble FcεRII release by human monocytes. Int Immunol 1995; 7:705–713.PubMedCrossRefGoogle Scholar
  60. 60.
    Moretta L, Ferrrarini M, Durante ML et al. Expression of a receptor for IgM by human T cells in vitro. Eur J Immunol 1975; 5:565.PubMedCrossRefGoogle Scholar
  61. 61.
    Mathur A, Lynch RG, Kohler G. Expression, distribution and specificity of Fc receptors for IgM on murine B cells. J Immunol 1988; 141: 1855–1862.PubMedGoogle Scholar
  62. 62.
    Pricop L, Rabinowich H, Morel P et al. Characterization of the Fc mu receptor on human natural killer cells. J Immunol 1993; 151:3018–3029.PubMedGoogle Scholar
  63. 63.
    Sanders SK, Kubagawa H, Suzuki T et al. IgM binding protein expressed by activated B cells. J Immunol 1987; 139:188.PubMedGoogle Scholar
  64. 64.
    Nakamura T, Kubagawa H, Ohno T et al. Characterization of an IgM Fc-binding receptor on human T Ccells. J Immunol 1993; 151:6933–6941.PubMedGoogle Scholar
  65. 65.
    Swenson C, Amin A, Xue B et al. Regulation of IgD-receptor expression on murine T cells. I. Characterization and metabolic requirements of the process leading to their expression. Cell Immunol 1993; 152:405–421.PubMedCrossRefGoogle Scholar
  66. 66.
    Amin A, Swenson C, Xue B et al. Regulation of IgD-receptor expression on murine T cells. Cell Immunol 1993; 152:422–439.PubMedCrossRefGoogle Scholar
  67. 67.
    Burton DR, Woof JM. Human antibody effector function. Adv Immunol 1992; 51:1–84.PubMedCrossRefGoogle Scholar
  68. 68.
    Labbe S, Grenier D. Characterization of the human immunoglobulin G Fc-binding activity in prevotella intermedia. Infect Immun 1995; 63:2785–2789.PubMedGoogle Scholar
  69. 69.
    Vincendeau P, Daëron M. Trypanosoma musculi co-express several receptors binding rodent IgM, IgE and IgG subclasses. J Immunol 1989; 142:1702–1709.PubMedGoogle Scholar
  70. 70.
    Oleszak E, Kuzmak J, Hogue B et al. Molecular mimicry between Fc receptor and S peplomer protein of mouse hepatitis virus, bovine corona virus, and transmissible gastroenteritis virus. Hybridoma 1995; 14:1–8.PubMedCrossRefGoogle Scholar

Copyright information

© R.G. Landes Company 1997

Authors and Affiliations

  • Catherine Sautès

There are no affiliations available

Personalised recommendations