Current Therapy in Nephrology pp 298-302 | Cite as
Cellular Aspects of Biocompatibility
Abstract
In hemodialysis patients, the anaphylatoxins C3a and C5a can be generated as a result of dialysis membrane-induced activation of the alternate pathway of the complement system. Complement activation was temporally correlated with hemodialysis leukopenia using cuprophan dialyzers. By contrast, patients dialyzed with polyacrylonitrile dialyzers failed to exhibit hemodialysis leukopenia and displayed only modest increases in their plasma C3a levels (1). C5a mediates the expression of a granulocyte-adhesion-promoting surface glycoprotein on granulocytes providing leukoaggregation, sequestration of granulocytes, and neutropenia during hemodialysis (2). A specific C5a receptor on human polymorphonuclear leukocytes has been demonstrated (3). On the other hand, polymorphonuclear neutrophils and monocytes obtained from chronic dialysis patients have a significant reduction in their ability to bind C5a (4).
Keywords
Calcium Channel Blocker Complement Activation Polymorphonuclear Neutrophil Human Polymorphonuclear Leukocyte Chronic Dialysis PatientPreview
Unable to display preview. Download preview PDF.
References
- 1.Chenoweth, D.E., Cheung, A.K. and Henderson, L.W. Kidney Int. 24:764–769, 1983.PubMedCrossRefGoogle Scholar
- 2.Arnaout, M.A., Hakim, R.M., Todd, R.F., Dana, N. and Colton, H.R. N. Engl. J. Med. 312: 457–462, 1985.PubMedCrossRefGoogle Scholar
- 3.Chenoweth, D.E. and Hugli, T.E. Proc. Natl. Acad. Sci. USA 75: 3943–3947, 1978.PubMedCrossRefGoogle Scholar
- 4.Lewis, S.L., Van Epps, D.E. and Chenoweth, D.E. Clin. Nephrol. 26: 37–44, 1986.PubMedGoogle Scholar
- 5.Hörl, W.H., Steinhauer, H.B. and Schollmeyer, P. Kidney Int. 28: 791–796, 1985.PubMedCrossRefGoogle Scholar
- 6.Hörl, W.H. and Heidland, A. Clin. Nephrol. 21:314–322, 1984.PubMedGoogle Scholar
- 7.Hörl, W.H., Riegel, W., Schollmeyer, P., Rautenberg, W. and Neumann, S. Clin. Nephrol. 25: 304–307, 1986.PubMedGoogle Scholar
- 8.Riegel, W., Leverenz, K., Schollmeyer, P., Wilms, H. and Hörl, W.H. Nephron 46:161–166, 1987.PubMedCrossRefGoogle Scholar
- 9.Hörl, W.H., Riegel, W. and Schollmeyer P. Nephron 45: 272–276, 1987.PubMedCrossRefGoogle Scholar
- 10.Schaefer, R.M., Heidland, A. and Hörl, W.H. Am. J. Nephrol. 7: 121–126, 1987.PubMedCrossRefGoogle Scholar
- 11.Schultze, G., Wagner, K., Neumayer, H.H. and Molzahn, M. Contr. Nephrol. 59: 44–50, 1987.Google Scholar
- 12.Schultze, G., Wagner, K., Fitzner, R., Neumayer, H.H. and Molzahn, M. Kidney Int. 33 (Suppl. 24): S-82–S-83, 1988.Google Scholar
- 13.Mahiout, A., Lajous-Peter, A.M., Jörres, A., Meinhold, H. and Kessel, M. Kidney Int. 33 (Suppl. 24):S-75–S-79, 1988.Google Scholar
- 14.Tetta, C., Camussi, G., Segoloni, G. and Vercellone, A. Kidney Int. 29: 609, 1986.Google Scholar
- 15.Foidart, J.B., Davin, J.C., Malaise, M., Saint-Remy, M. and Mahien, P. Kidney Int. 33 (Suppl. 24):S-80–S-81, 1988.Google Scholar
- 16.Betz, M., Hensch, G.M., Rauterberg, E.W. and Ritz, E. Kidney Int. 31: 228, 1987.Google Scholar
- 17.Haag-Weber, M., Schollmeyer, P. and Hörl, W.H. Eur. J. Clin. Invest, (in press).Google Scholar
- 18.Riegel, W., Spillner, G., Schlosser, V. and Hörl, W.H. J. Thorac. Cardiovasc. Surg. 95: 1014–1019, 1988.PubMedGoogle Scholar
- 19.Bingel, M., Lonnemann, G., Shaldon, S., Koch, K.M. and Dinarello, C. A. Nephron 43:161–163, 1986PubMedCrossRefGoogle Scholar
- 20.Lonnemann, G., Bingel, M., Floege, J., Koch, K.M, Shaldon, S. and Dinarello, C.A. Kidney Int. 33: 29–35, 1988.PubMedCrossRefGoogle Scholar
- 21.Dinarello, C.A., Koch, K.M. and Shaldon, S. Kidney Int. 33(Suppl. 24): S-21–S-23, 1988.Google Scholar
- 22.Colton, C.K. Kidney Int. 33(Suppl. 24): S-27–S-29, 1988.Google Scholar