Isolation And Biochemical Characterization Of The D1 And D2 Dopamine Receptors

  • Jay A. Gingrich
  • Susan E. Senogles
  • Nourdine Amilaiky
  • Wei K. Chang
  • Joel G. Berger
  • Marc G. Caron
Chapter

Abstract

The catecholamine, dopamine, exerts physiologic effects in both the central nervous system and the periphery. Dopamine systems in the central nervous system (CNS) have been implicated in several neurologic and psychiatric disorders such as Parkinsonism, schizophrenia, Huntington’s chorea, Tourette’s syndrome, and Lesch-Nyhan syndrome. In the periphery, dopamine plays a role in processes controlling renal vascular tone and release of the hormones, prolactin from the anterior pituitary gland and parathyroid hormone from the parathyroid gland. The symptoms of some pathological processes are ameliorated through the use of drugs targeted toward the receptors for dopamine. For example, dopamine agonists have been successfully used to treat Parkinson’s disease, hyperprolactinemia (prolactinomas), and to prevent renal ischemia associated with cardiovascular collapse (shock), and dopamine antagonists have proven useful in the treatment of schizophrenia, and Tourette’s syndrome.

Keywords

Dopamine Receptor Guanine Nucleotide Binding Protein Striatal Tissue Photoaffinity Labelling Renal Vascular Tone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Jay A. Gingrich
    • 1
  • Susan E. Senogles
    • 1
  • Nourdine Amilaiky
    • 1
  • Wei K. Chang
    • 2
  • Joel G. Berger
    • 2
  • Marc G. Caron
    • 1
  1. 1.Departments of Physiology Medicine, Howard Hughes Medical Institute LaboratoriesDuke University Medical CenterDurhamUSA
  2. 2.Research DivisionSchering-Plough CorpBloomfieldUSA

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