Cholesterol Ester Transfer Protein, Characterization of Monoclonal Antibodies against the Human Antigen

  • Y. L. Marcel
  • R. W. Milne
  • P. K. Weech
  • H. Czarnecka
  • C. B. Hesler
  • A. R. Tall
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 243)

Abstract

Early work by Rehnborg and Nichols (1) showed that upon incubation of normolipemic plasma, cholesteryl ester (CE) concentration increased in VLDL, LDL and HDL whereas triglycerides (TG) concentration decreased in VLDL and increased in LDL and HDL. These experiments (1,2) were the first to document CE transfer between lipoproteins but the concept was really developed with the demonstration by Zilversmit et al (3) that the d > 1.21 g/ml fraction contained a protein that catalysed CE transfer between lipoproteins, a protein which is now identified as cholesterolester transfer protein (CETP) and which transfers CE and TG between lipoproteins.

Keywords

Cholesteryl Ester Reverse Cholesterol Transport Cholesterol Ester Transfer Protein Cholesterol Ester Transfer Protein Activity Cholesteryl Ester Transfer Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Y. L. Marcel
    • 2
  • R. W. Milne
    • 2
  • P. K. Weech
    • 2
  • H. Czarnecka
    • 1
  • C. B. Hesler
    • 1
  • A. R. Tall
    • 2
  1. 1.Clinical Research Institute of MontrealMontrealCanada
  2. 2.Department of MedicineColumbia University College of Physicians & SurgeonsUSA

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