Advances in Nutritional Research pp 1-10 | Cite as
The Transfer of Nutrients across the Perfused Human Placenta
Chapter
Abstract
In this discussion of in vitro perfusion of human placenta as an approach to the study of fetal nutrition I shall: (1) explain why, in recent years, we have discontinued using experimental animals and concentrated on human placenta; (2) describe the perfusion technique; (3) review our studies of two nutrients, glutamic acid and riboflavin, to illustrate the flexibility of experimental design that is possible and the type of information that can be obtained; (4) summarize the limitations and the potential of the perfusion technique as we have observed them.
Keywords
Glutamic Acid Human Placenta Fetal Circulation Perfusion Technique Fetal Lamb
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Preview
Unable to display preview. Download preview PDF.
References
- Brambell, F. W. R., Hemming, W. A., and Henderson, M., 1951, Antibodies and Embryos, Athlone Press, London.Google Scholar
- Dancis, J., Lind, J., Oratz, M., Smolens, J., and Vara, P., 1961, Placental transfer of proteins in human gestation, Am. J. Obstet. Gynecol. 83: 167.Google Scholar
- Dancis, J., Lehanka, J., and Levitz, M., 1985a, Transfer of riboflavin by the perfused human placenta, Pediatr. Res. 19: 1143CrossRefGoogle Scholar
- Dancis, J., Schneider, H., and Challier, J.-C., 1985b, “Nutrition of the placenta and fetus,” in: Feeding the Mother and Infant ( M. Winick, ed.), pp. 59–72, Wiley, New York.Google Scholar
- Dancis, J., Lehanka, J., Levitz, M., and Schneider, H., 1986, Establishment of gradients of riboflavin, L-lysine, and 2-aminoisobutyric acid across the perfused human placenta, J. Reprod. Med. 31: 293.Google Scholar
- Dancis, J., Lehanka, J., and Levitz, M., 1988, Placental transport of riboflavin: differential rates of uptake at the maternal and fetal surfaces of the perfused human placenta, Am. J. Obstet. Gynecol. 158: 204.Google Scholar
- Hobbs, J. R., and Davis, J. A., 1967, Serum y-G globulin levels and gestational age in premature babies, Lancet 1967 (1): 757.CrossRefGoogle Scholar
- Howard, R. B., Hosokawa, T., and Maguire, M. H., 1987, Hypoxia-induced fetoplacental vasoconstriction in perfused human placental cotyledons, Am. J. Obstet. Gynecol. 157: 1261.Google Scholar
- Kirshenbaum, N. W., Dancis, J., Levitz, M., Lehanka, J., and Young, B. K., 1987, Riboflavin concentration in maternal and cord blood in human pregnancy, Am. J. Obstet. Gynecol. 157: 748.Google Scholar
- Schneider, H., Panigel, M., and Dancis, J., 1972, Transfer across the perfused human placenta of antipyrine, sodium and leucine, Am. J. Obstet. Gynecol. 114: 822.Google Scholar
- Schneider, H., Mohlen, K.-H., Challier, J.-C., and Dancis, J., 1979, Transfer of glutamic acid across the human placenta perfused in vitro, Br. J. Obstet. Gynecol. 86: 299.CrossRefGoogle Scholar
Copyright information
© Plenum Press, New York 1990