Adhesion Molecules in Leukocyte Endothelial Interaction

  • Amos Etzioni
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 408)


Neutrophils are the front line defense against most microbial pathogens. They provide a rapid, relatively nonspecific defense mechanism, after which a more long lasting, antigen-specific response is established by T and B lymphocytes. To fulfill this role successfully, the neutrophil must be able to migrate from the blood into the area of inflammation, a process which involves activation of endothelial cells and leukocyte by inflammatory stimuli, adherence to the endothelial surface at the site of inflammation, and migration through endothelium to extravascular tissue. The orchestration of these steps must by precisely regulated to ensure a rapid response to isolate and destroy the invading pathogen yet cause minimal damage to healthy tissues (Etzioni and Douglas 1993). The process of leukocyte accumulation at sites of inflammation is a dynamic one, involves multiple steps and is mediated by several families of adhesion molecules (Springer 1995). These include the Integrins, the Selectins and members of the Immunoglobulin (Ig) superfamily. Each is involved in a different phase of leukocyte emigration through the endothelium and the synchronization of their expression and function is crucial for the normal recruitment of leukocyte from the blood stream to the tissue (Etzioni 1996).


Adhesion Molecule Firm Adhesion Leukocyte Rolling Leukocyte Adhesion Deficiency Nervous System Damage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Anderson DC, Kishimoto TK, Smith CW. 1995 Leukocyte adhesion deficiency and other disorders of leukocyte adherence and motility. In: Scriver CR, Beaudet AL, Sly WS, Valle D. Eds: The metabolic and molecular bases of inherited diseaes. 7th Ed. McGraw-Hill, New-York pp3955–95.Google Scholar
  2. Bevilaqua MP 1993 Endothelial leukocyte adhesion molecules. Ann Rev Immunol 11:767–804.CrossRefGoogle Scholar
  3. Etzioni A, Frydman M, Pollack S, Avidor I, Phillips ML, Pualsom JC, Gershoni-Baruch R 1992 Severe recurrent infections due to a novel adhesion molecule defect. New Engl J Med 327:1789–92.PubMedCrossRefGoogle Scholar
  4. Etzioni A, Douglas DS. 1993 Microbial phagocytosis and killing in host defense. In Spirer Z, Roifman CM, Branski D.Eds: Pediatric Immunology. Karger, Basel pp 17–27.Google Scholar
  5. Etzioni A 1994 Adhesion molecule deficiencies and their clinical significance. Cell Adhes Comm 2:257–60.CrossRefGoogle Scholar
  6. Etzioni A. 1996 Adhesion molecules - their role in health and disease. Ped Res 39:191–8.CrossRefGoogle Scholar
  7. Harlan JM 1993 Leukocyte adhesion deficiency syndrome: Insights into the molecular basis of leukocyte emigration. Clin Immunol Immunopathol 67:sl6-s24.PubMedCrossRefGoogle Scholar
  8. Hynes RO 1992 Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69:11–25.PubMedCrossRefGoogle Scholar
  9. Kishimoto TK, Rothlein R 1993 Adhesion molecules which guide neutrophil endothelial cell interaction at site of inflammation. In: Gupta S, Griscelli C, eds. New concepts in immunodeficiency diseases. New York, John Wiley & Sons. 131–52.Google Scholar
  10. Kubes P, Jutila M, Payne D. 1995 Therapeutic potential of inhibiting leukocyte rolling in ischemia/reperfusion. J Clin Invest 95:2510–9.PubMedCrossRefGoogle Scholar
  11. Ley K, Bullard DC, Arbones ML, Bosse R, Vestweber D, Tedder TF, Beaudet Al. 1995 Sequential contribution of L- and P-selectin to leukocyte rolling in vivo. J Exp Med 181:669–75.PubMedCrossRefGoogle Scholar
  12. Springer TA. 1995 Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Ann Rev Physiol. 57:827–72.CrossRefGoogle Scholar
  13. Tedder TF, Steeber DA, Chen A, Engel P. The selectins: vascular adhesion molecules. FASEB J 9:866–73.PubMedGoogle Scholar
  14. Varki A, 1994 Selectin ligands. Proc Natl Acad Sci USA 91:7390–97.PubMedCrossRefGoogle Scholar
  15. von-Andrian UH, Berger EM, Ramezani L, Chambers JD, Ochs HD, Harlan JM, Paulson JC, Etzioni A, Arfors KE 1993 In vivo behavior of neutrophils from two patients with distinct inherited leukocyte adhesion deficiency syndromes. J Clin Invest 91:2893–7PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Amos Etzioni
    • 1
  1. 1.Department of Pediatrics and Clinical ImmunologyRambam Medical Center, Faculty of Medicine TechnionHaifaIsrael

Personalised recommendations