Effects of Monoterpenes and Mevinolin on Murine Colon Tumor CT-26 in Vitro and its Hepatic “Metastases” in Vitro

  • Selwyn A. Broitman
  • John WilkinsonIV
  • Sonia Cerda
  • Steven K. Branch
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 401)


d-Limonene is a monocyclic monoterpene which has been used for many years as a flavoring, perfuming, or degreasing agent. Recently, this product and its biologic metabolites have been highlighted for their chemotherapeutic potential in the management of certain common malignant diseases. Some of its metabolic actions interfere with certain aspects of cholesterol metabolism which are vital to the malignant cell and hopefully less critical to the normal cell. The mammalian cell has, as a major component of its plasma membrane, cholesterol which helps to maintain the integrity of the cell, and modulates the fluidity of the cellular lipid membrane. It thus serves as a major regulatory agent for chemical signals sent from other cells, transport of critical metabolites in and out of the cell, and for the membrane association of receptors, enzymes, and a wide variety of proteins which serve to regulate the intracellular processes of the cell.1


Cholesterol Synthesis Colon Tumor CT26 Cell Colon Tumor Cell Perillyl Alcohol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations used




fetal bovine serum

HMG CoA reductase

3-hydroxy-3-methylglutaryl Coenzyme A reductase




low density lipoprotein


LDL receptor


lipoprotein deficient serum




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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Selwyn A. Broitman
    • 1
  • John WilkinsonIV
    • 1
  • Sonia Cerda
    • 1
  • Steven K. Branch
    • 1
  1. 1.Departments of Microbiology, and Pathology and Laboratory MedicineBoston University School of Medicine and the Mallory Institute of PathologyBostonUSA

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