Effect of Valine on 5-HT Neurotransmission and Mood
Changes in brain serotonin (5-HT) function have been implicated in both the aetiology of mood disorders and the actions of antidepressant drugs (for reviews see Delgado et al, 1992; Cowen, 1993). Recently, Delgado et al (1990) have reported that a 100g amino acid mixture, free of the 5-HT precursor, L-tryptophan (TRP), causes an acute symptomatic relapse in remitted depressed patients maintained on antidepressant drugs. This relapse has been attributed to an abrupt decline in the availability of TRP for brain 5-HT synthesis which temporarily reverses the effects of the antidepressant drug treatment.
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