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The Antihistamine Action of Ascorbic Acid

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Book cover Subcellular Biochemistry

Part of the book series: Subcellular Biochemistry ((SCBI,volume 25))

Abstract

Histamine is a critical messenger molecule in times of stress, promoting alertness, blood flow, and healing (Kahlson et al., 1960; Schayer, 1962; White and Rumbold, 1988). Excess histamine, however, has a negative impact on circulatory and immunologic homeostasis (Schayer, 1962; Falus and Merétey, 1992) and aggravates inflammatory conditions of the gut (Rangachari, 1992) and respiratory tract (Doyle et al., 1994). Thus, antihistamine therapy is used for systematic treatment of certain diseases, including acid-peptic disorders (Feldman and Burton, 1990b), allergy (howarth, 1983; Schata et al., 1991; Naclerio, 1993), and inflammatory skin disorders (Giacosa et al.,1978).

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Abbreviations

AMP:

adenosine monophosphate

cGMP:

cyclic guanine monophosphate

Con A:

concanavalin A

DAO:

diamine oxidase

Fc:

antibody crystallizable fragment

FEV:

forced expiratory volume

H1 :

histidine receptor 1

HDC:

histidine carboxylase

HFC:

histamine forming capacity

HMT:

histamine-N-methyltransferase

HPLC:

high-performance liquid chromatography

HRF:

histamine releasing factor

HSF:

histamine-induced suppressor factor

IgE:

immunnoglobulin E

IL-1:

interleukin-1

INF:

interferon

LDL:

low-density lipoprotein

MEF:

maximal expiratory flow

MHC:

major histocompatibility complex

MIF:

migration inhibition factor

NMR:

nuclear magnetic resonance

ODS:

osteogenic disorder Shionogi

PAF:

platelet activating factor

UDP:

uridine diphosphate

VLDL:

very low density lipoprotein.

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  1. Department of Family Resources and Human Development, Arizona State University, Tempe, Arizona, 85287-2502, USA

    Carol S. Johnston

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  1. Institute of Zoology, University of Mainz, Mainz, Germany

    J. Robin Harris

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Johnston, C.S. (1996). The Antihistamine Action of Ascorbic Acid. In: Harris, J.R. (eds) Subcellular Biochemistry. Subcellular Biochemistry, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0325-1_10

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