Serum Blocking Factor-Mediated Decrease of T-Cell Immunity Induced by Soluble Histocompatibility Antigens (SHA); Similar Effects of Antibody-free SHA-raised and Hemagglutinating-enhancing Sera

  • O. Halle-Pannenko
  • L. Berumen
  • N. Abuaf
  • G. Mathe
Conference paper
Part of the Experimental Hematology Today book series (HEMATOLOGY, volume 1978)

Abstract

Alloantigen-extract mediated graft enhancement has been widely studied. Many investigators have observed a decreased host-versus-graft (HvG) (10,16,17,19,22,30) or graft-versus-host (GvH) (11,13,23,29) reaction after the injection of crude or soluble tissue extracts, although contradictory results indicating an accelerated graft rejection have also been reported (7,8). We have previously noted (11) that several factors may influence the response to alloantigen-extract administration. These include the organ used for the extraction; the “density” of the H-2 D and K antigens; the physical form of the extract; the dosage, frequency, and route of administration; the interval between time of administration and subsequent challenge; and the amount of an as yet undefined substance in the extract. The variability of these factors, plus the variety of species used and the donor-recipient genetic disparities involved, along with the inevitable variation in microbiological and environmental conditions influencing the immunoreactivity of experimental animals, provides, at least in part, an explanation for many of the discrepancies among the results reported by different laboratories.

Keywords

Spleen Cell Skin Graft Donor Cell Mixed Lymphocyte Reaction Allograft Survival 
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Copyright information

© Springer-Verlag New York Inc. 1978

Authors and Affiliations

  • O. Halle-Pannenko
  • L. Berumen
  • N. Abuaf
  • G. Mathe

There are no affiliations available

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