Frontiers in Hypertension Research pp 91-93 | Cite as
Alteration of Cell Membrane Control over Intracellular Calcium in Essential Hypertension and in Spontaneously Hypertensive Rats
Abstract
In recent years, a series of facts have shown that cell membranes may be considered a basic determinant that can activate blood pressure control systems. These facts concern both essential hypertension in humans and spontaneous hypertension in rats. In both types of pathology, there is now evidence that a cell membrane defect is not restricted to the arterial wall, but is a part of a more widespread pattern. The first indication of this appeared in the study concerning passive permeability of the erythrocyte membrane for sodium and potassium ions. It was found, particularly by our group, that passive permeability of the erythrocyte membrane for these cations increased considerably in both types of hypertension (1, 2). These data agreed with the findings of Losse et al. (3) who earlier found an increase of sodium content in red blood cells (RBC) in essential hypertensive patients.
Keywords
Essential Hypertension Erythrocyte Membrane Passive Permeability Calcium Pool Membrane DefectPreview
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References
- 1.Postnov YuV, Orlov SN, Shevchenko AS (1975) Alteration of the erythrocyte membrane permeability in rats with spontaneous genetic hypertension (in Russian). Cardiology (Moscow) 15 (10): 88–92PubMedGoogle Scholar
- 2.Postnov YuV, Orlov SN, Shevchenko AS, Adler AM (1977) Altered sodium permeability, calcium binding and Na-K-ATPase activity in red blood cell membrane in essential hypertension. Pfluegers Arch 371: 263–269CrossRefGoogle Scholar
- 3.Losse H, Wehmeyer H, Zumkley H (1966) The behaviour of the intracellular electrolytes in arterial hypertension. In: Electrolytes and cardiovascular diseases. Karger, Basel/New York, pp 174–197Google Scholar
- 4.Postnov YuV, Orlov SN, Pokudin NI (1979) Decrease of calcium binding by the red blood cell membrane in spontaneously hypertensive rats and in essential hypertension. Pfluegers Arch 379: 191–195CrossRefGoogle Scholar
- 5.Jones AW (1973) Altered ion transport in vascular smooth muscle from spontaneously hypertensive rats: Influence of aldosterone, norepinephrine and angiotensin. Circ Res 34, 35 (Suppl I): 62–69Google Scholar
- 6.Aoki K, Ikedo N, Yamashita K, Tazumi K, Sato I, Hotta K (1974) Cardiovascular contraction in spontaneously hypertensive rats: Ca2+ interaction of myofibrils and subcellular membrane of heart and arterial smooth muscle. Jpn Circ J 38: 1115–1119PubMedCrossRefGoogle Scholar
- 7.Postnov YuV, Orlov SN (1979) Features of intracellular calcium distribution in the adipose tissue of spontaneously hypertensive rats ( SHR ). Experientia 35: 1480–1481PubMedCrossRefGoogle Scholar
- 8.Postnov YuV, Orlov SN, Pokudin, NI (1980) Alteration of intracellular calcium distribution in the adipose tissue in essential hypertension (in Russian). Cardiology (Moscow) 20 (8): 65–67PubMedGoogle Scholar
- 9.Postnov YuV, Orlov SN (1980) Evidence of altered calcium accumulation and calcium binding by the membranes of adipocytes in spontaneously hypertensive rats. Pfluegers Arch 385: 85–89CrossRefGoogle Scholar
- 10.Wei W-J, Janis RA, Daniel EE (1976) Studies of subcellular fraction from mesenteric arteries of spontaneously hypertensive rats: Alteration in both calcium uptake and enzyme activities. Blood Vessels 13: 293–308PubMedGoogle Scholar
- 11.Postnov YuV, Reznikova MB (1980) Phosphodies-terase and adenylate cyclase activity in adipocytes of spontaneously hypertensive rats. In: Seventh Scientific Meeting of the International Society of Hypertension, New Orleans, May 11–14, p 104Google Scholar
- 12.Postnov YuV, Orlov SN, Pokudin NI (in press) Peripheral immunosympathectomy in spontaneously hypertensive rats: Altered intracellular calcium distribution in adipose tissue in the absence of hypertension (in Russian). Cardiology (Moscow) 20(9).Google Scholar