A Role for Propionibacterium acnes in the Production of Inflammatory Lesions in Acne Vulgaris

  • Guy F. Webster


Acne vulgaris is a two-stage disease. The first stage involves the formation of a comedo, an impaction and distension of the sebaceous follicle by a horny mass containing sebum, hair, and bacteria. Some comedones progress no farther, while others, mainly closed comedones, evolve into angry, potentially disfiguring inflammatory lesions.7 It is not known why only some comedones become inflammatory lesions (papules, pustules, and nodules), but the stimulus for the inflammation, when it occurs, is increasingly clear.


Complement Activation Chemotactic Factor Normal Human Serum Propionibacterium Acne Acne Patient 
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© Springer-Verlag New York, Inc. 1981

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  • Guy F. Webster

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