Virus-Induced Autoimmunity

  • Abner Louis Notkins
  • Takashi Onodera
  • Bellur Prabhakar


Many important human diseases of undetermined etiology have an autoimmune component. In some diseases, the autoimmune component is very broad, involving a number of different organs and tissue antigens. For example, in the case of systemic lupus erythematosus, autoantibodies are found that react with DNA, RNA, cytoplasmic proteins, lymphocytes, and erythrocytes. Similarly, in patients with polyendocrinopathy, autoantibodies that react with the pancreas, thyroid, pituitary, and gastric mucosa have been detected. In contrast, in diseases such as myasthenia gravis, the autoimmune component is far more restricted and predominantly directed against the acetylcholine receptor.


Infectious Mononucleosis Japanese Encephalitis Virus Autoimmune Component Normal Host Cell Monoclonal Autoantibody 
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Copyright information

© Springer-Verlag New York Inc. 1984

Authors and Affiliations

  • Abner Louis Notkins
  • Takashi Onodera
  • Bellur Prabhakar
    • 1
  1. 1.National Institutes of HealthBethesdaUSA

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