Growth, Cancer, and the Cell Cycle pp 323-345
Cell Growth, Tissue Neogenesis, and Neoplastic Transformation
Exponential growth is rarely observed in vivo. most mammalian tissues, whether normal or malignant, exhibit nonexponential kinetics in which growth decelerates continuously with time (1–10). This deceleration is characterized by a gradual but progressive increase in a tissue’s doubling time, and a corresponding decline in its specific growth rate.
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