Ribosome Structure, Function, and Evolution: Mapping Ribosomal RNA, Proteins, and Functional Sites in Three Dimensions
Major advances have been made in recent years in our understanding of the structure, function, and evolution of ribosomes. One notes that the overall three-dimensional structures of ribosomes and ribosomal subunits are known; the primary and secondary structures of the rRNA are known for many diverse organisms; the approximate locations of many ribosomal proteins and of some sequences of the ribosomal RNAs are known; many aspects of ribosome function have been related to ribosome structure; and, finally, comparative studies of ribosomes have revealed some of the early steps in the evolution of ribosomes and of the cells that contain them.
KeywordsRibosomal Protein Large Subunit Small Subunit Ribosomal Subunit Large Ribosomal Subunit
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- Bernabeu, C., Lake, J.A. (1982b). Packing of 70S ribosomes in dimers found at low ionic strength. J. Mol. Biol 160: 369373.Google Scholar
- Clark, W., Lake, J.A. (1983). Unusual rRNA-linked complex of 50S ribosomal subunits isolated from an Escherichia coli RNase III mutant. J. Bact 157: 971–974.Google Scholar
- Johnson, A.E., Fairclough, R.H., Cantor, C.R. (1977). Some approaches for the study of ribosome-tRNA interactions. In: Nucleic Acid-Protein Recognition, ed. Vogel, H.J., Academic Press, New York, pp. 469–490.Google Scholar
- Lake, J.A. (1979). Ribosome structure and tRNA binding sites. In: Transfer RNA: structure, properties and recognition. Cold Spring Harbor Press, New York, pp. 393–411.Google Scholar
- Lake, J.A. (1979a). Ribosome structure and functional sites. In: Ribosomes, structure, function and genetics, eds. Chambliss et al., University Park Press, Baltimore, pp. 201–236.Google Scholar
- Lake, J.A. (1981b). Protein synthesis in prokaryotes and eukaryotes: the structural bases. In: Electron Microscopy of Proteins, ed. Harris, R., Academic Press, London, pp. 167–195.Google Scholar
- Lake, J.A., Nonomura, Y., Sabatini, D.D. (1974a). Ribosome structure as studied by electron microscopy. In: Ribosomes, eds. Nomura, M. et al., Cold Spring Harbor Press, New York, pp. 543–557.Google Scholar
- Noller, H.F., Lake, J.A. (1984). Ribosome structure and function: localization of rRNA. In: Membrane Structure and Function, vol. 6, ed. Bittar, E. John Wiley and Sons, New York, pp. 217–297.Google Scholar
- Stöffler-Meilicke, Stöffler, G., Odom, O.W., Zinn, A., Kramer, G., Hardesty, B. (1982). Localization of 3′-ends of 5S and 23S rRNA’s in reconstituted subunits of Escherichia coli ribosomes. Proc. Natl. Acad. Sei. USA 78: 5538–5542.Google Scholar
- Zillig, W., Schnabel, R., Stetter, K.O. (1985). Archaebacteria and the origin of the eukaryotic cytoplasm. Curr. Topics Microbiol 114: 1–18.Google Scholar