Environmental Factors in Cataractogenesis in RCS Rats

  • Helen H. Hess
  • J. S. ZiglerJr.
  • T. L. O’Keefe
  • J. J. Knapka
Chapter
Part of the Cell and Developmental Biology of the Eye book series (EYE)

Abstract

Royal College of Surgeons (RCS) rats have an inherited disease of the retinal pigmented epithelium (RPE), which shows a greatly reduced capacity to phagocytize the shed terminal portion of the outer segment of the rod photoreceptor cell (Mullen & LaVail, 1976). This failure in the symbiotic relationship of these two cells results in accumulation of outer segment membrane debris at the interface between the cells, and the lack of normal nutriture and membrane renewal leads to the death of all the rod photoreceptors by about 65 days in pink-eyed dystrophies and by 100 days in black-eyed dystrophies (LaVail & Battelle, 1975).

Keywords

Retinal Pigment Epithelium Retinal Degeneration Cyclic Light Retinal Pigment Epithelium Retinal Dystrophy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • Helen H. Hess
  • J. S. ZiglerJr.
  • T. L. O’Keefe
  • J. J. Knapka

There are no affiliations available

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