Historical Perspectives

  • Samuel S. Wang
  • Stephen J. Peroutka
Chapter
Part of the The Receptors book series (REC)

Abstract

For more than 100 years, scientists have been aware that an endogenous vasoconstrictor substance is present in blood. The first investigators to recognize that the substance increased in clotted blood were Stevens and Lee (1884) and Brodie (1900). Further progress was not made until 1911, when several investigators noted that their studies of epinephrine were complicated by the appearance of a vasoconstrictor substance found in serum. Kaufmann (1913) found that adrenalectomy did not prevent the appearance of this substance in serum. In 1933, Erpsamer and colleagues in Italy identified a substance they called “enteramine” in the intestine (Vialli and Erpsamer, 1933), although the relationship of this compound to the serum factor was not yet known.

Keywords

Serotonin Receptor Dorsal Raphe Nucleus Acoustic Startle Response Brain Membrane Behavioral Syndrome 
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© The Humana Press Inc. 1988

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  • Samuel S. Wang
  • Stephen J. Peroutka

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