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Tumor Promotion in Liver

  • Michael Schwarz
Chapter

Abstract

The concepts of initiation and promotion in liver must be viewed in the backdrop of some basic observations on stages in hepatocarcinogenesis. As originally described independently by two groups (1,2), small foci of cells, hereafter called altered hepatic foci (AHF), appear in the liver shortly after exposure of experimental animals to a hepatocarcinogen. AHF are characterized by increases or decreases in the activity and/or level of a large variety of different enzymes and cellular substrates which can be used as markers for their identification. Among many others, these include the enzymes γ-glutamyl transferase (GGT) (3–5), adenosine triphosphatase (6–10), glucose-6-phosphatase (2), various cytochrome P-450 species (11,12), epoxide hydrolase (12), glucuronyl transferase (13), the placental form of glutathione transferase (14,15), and cellular glycogen content (16,17). The enzyme, glutathione transferase P, may even be used to detect single enzyme-altered liver cells (18). For recent summaries on enzyme changes in AHF reported in the literature, see references (19,20). AHF have been shown to be monoclonal in origin (21–23) and display, in comparison to their surrounding normal hepatocytes, increased cell proliferation (24–29). Accumulating evidence suggests that at least some of the AHF represent precursor lesions which are causally related to the carcinogenic process in liver.

Keywords

Liver Tumor Tumor Promoter Intercellular Communication Peroxisome Proliferators Ethinyl Estradiol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bannasch, P., and Müller, H. A.: Arzneim.-Forsch. 14, 805 (1964).Google Scholar
  2. 2.
    Gössner, W., and Friedrich-Freksa, H.: Z. Naturforsch. B19, 862 (1964).Google Scholar
  3. 3.
    Kalengayi, M. M., Ronchi, G., and Desmet, V. J.: J. Natl. Cancer Inst. 55, 579 (1975).PubMedGoogle Scholar
  4. 4.
    Solt, D., and Farber, E.: Nature 263, 701 (1976).CrossRefGoogle Scholar
  5. 5.
    Pitot, H. C., Barsness, L., Goldsworthy, T., and Kitagawa, T.: Nature 271, 456 (1978).PubMedCrossRefGoogle Scholar
  6. 6.
    Schauer, A., and Kunze, E.: Z. Krebsforsch. 70, 252 (1968).PubMedCrossRefGoogle Scholar
  7. 7.
    Börner, P., and Gössner, W.: Z. Naturforsch. B 23, 1085 (1968).PubMedGoogle Scholar
  8. 8.
    Kitagawa, T.: Gann 62, 207 (1971).PubMedGoogle Scholar
  9. 9.
    Kunz, W., Appel, K. E., Rickart, R., Schwarz, M., and Stöckle, G. Enhancement and Inhibition of Carcinogenic Effectiveness of Nitrosamines. In “Primary Liver Tumors” (H. Remmer, H. M. Bolt, P. Bannasch, and H. Popper, eds.). MTP Press, Int. Medical Publishers, Lancaster, U.K., 1978, p. 261.Google Scholar
  10. 10.
    Emmelot, P., and Scherer, E.: Biochim. Biophys. Acta 605, 247 (1980).PubMedGoogle Scholar
  11. 11.
    Aström, A., de Pierre, J. W., and Eriksson, L.: Carcinogenesis 4, 577 (1983).PubMedCrossRefGoogle Scholar
  12. 12.
    Buchmann, A., Kuhlmann, W., Schwarz, M., Kunz, W., Wolf, C. R., Moll, E., Friedberg, T., and Oesch, F.: Carcinogenesis 6, 513 (1985).PubMedCrossRefGoogle Scholar
  13. 13.
    Bock, K. W., Lilienblum, W., Pfeil, H., and Erickson, L.C.: Cancer Res. 42, 3747 (1982).PubMedGoogle Scholar
  14. 14.
    Sato, K., Kitahara, A., Satoh, K., Ishikawa, T., Tatematsu, M., and Ito, N.: Gann 75, 199 (1984).PubMedGoogle Scholar
  15. 15.
    Tatematsu, M., Tsuda, H., Shirai, T. Masui, T., and Ito, N.: Toxicol. Pathol. 15, 60 (1987).PubMedCrossRefGoogle Scholar
  16. 16.
    Bannasch, P.: Recent Resu. Cancer Res. 19, 1 (1968).Google Scholar
  17. 17.
    Bannasch, P., Mayer, D., and Hacker, H. J.: Biochim. Biophys. Acta 605, 217 (1980).PubMedGoogle Scholar
  18. 18.
    Moore, M. A., Nakagawa, K., Satoh, K., Ishikawa, T., and Sato, K.: Carcinogenesis 8, 483 (1987).PubMedCrossRefGoogle Scholar
  19. 19.
    Peraino, C., Richards, W. L., and Stevens, F. J.: Multistage Carcinogenesis. In “Mechanisms of Tumor Promotion” (T. J. Slaga, ed.). CRC Press, Boca Raton, Florida, 1983, p. 1.Google Scholar
  20. 20.
    Pitot, H. C.: Annu. Rev. Pharmacol. Toxicol. 30, 465 (1990).PubMedCrossRefGoogle Scholar
  21. 21.
    Scherer, E., and Hoffmann, M.: Eur. J. Cancer 7, 369 (1971).PubMedCrossRefGoogle Scholar
  22. 22.
    Rabes, H. M., Bücher, T., Hartmann, A., Linke, I., and Dünnwald, M.: Cancer Res. 42, 3220 (1982).PubMedGoogle Scholar
  23. 23.
    Weinberg, W. C., Berkwits, L., and Innaccone, P. M.: Carcinogenesis 8, 565 (1987).PubMedCrossRefGoogle Scholar
  24. 24.
    Scherer, E., and Emmelot, P.: Eur. J. Cancer 11, 689 (1975).PubMedCrossRefGoogle Scholar
  25. 25.
    Schulte-Hermann, R., Ohde, G., Schuppler, J., and Timmermann-Trosiener. I.: Cancer Res. 41, 2556 (1981).PubMedGoogle Scholar
  26. 26.
    Schulte-Hermann, R., Timmermann-Troisiener, I., Barthel, G., and Bursch, W.: Cancer Res. 50, 5127 (1990).PubMedGoogle Scholar
  27. 27.
    Rabes, H. M., Scholze, P., and Jantsch, B.: Cancer Res. 32, 2577 (1972).PubMedGoogle Scholar
  28. 28.
    Rotstein, J., Sarma, D. S. R., and Farber, E.: Cancer Res. 46, 2377 (1986).PubMedGoogle Scholar
  29. 29.
    Bannasch, P.: J. Gastroenterol. Hepatol. 5, 149 (1990).PubMedCrossRefGoogle Scholar
  30. 30.
    Goldfarb, S., and Pugh, T. D.: Cancer Res. 41, 2092 (1981).PubMedGoogle Scholar
  31. 31.
    Potter, V. R.: Carcinogenesis 3, 1375 (1981).CrossRefGoogle Scholar
  32. 32.
    Potter, V. R.: Cancer Res. 44, 2733 (1984).PubMedGoogle Scholar
  33. 33.
    Scherer, E.: Arch. Toxicol. Suppl. 10, 81 (1987).PubMedGoogle Scholar
  34. 34.
    Kunz, H. W., Tennekes, H. A., Port, R. E., Schwarz, M., Lorke, D, and Schaude, G.: Environ. Health Perspect. 50, 113 (1983).PubMedCrossRefGoogle Scholar
  35. 35.
    Schwarz, M., Pearson, D., Buchmann, A., and Kunz, W.: The Use of Enzyme-Altered Foci for Risk Assessment of Hepatocarcinogens. In “Biologically Based Methods for Cancer Risk Assessment” (C. Travis, ed.), NATO ASI Series. Plenum, New York, 1989, p. 31.Google Scholar
  36. 36.
    Vesselinovitch, S. D., and Mihailovitch, N.: Cancer Res. 43, 4253 (1983).PubMedGoogle Scholar
  37. 37.
    Farber, E., Cancer Res. 33, 2537 (1973).PubMedGoogle Scholar
  38. 38.
    Farber, E.: Biochim. Biophys. Acta 605, 149 (1980).PubMedGoogle Scholar
  39. 39.
    Farber, E., and Cameron, R.: Adv. Cancer Res. 31, 125 (1980).PubMedCrossRefGoogle Scholar
  40. 40.
    Farber, E.: Cancer Res. 44, 4217 (1984).PubMedGoogle Scholar
  41. 41.
    Pitot, H.C., and Sirica, A. E.: Biochim. Biophys. Acta 605, 191 (1980).PubMedGoogle Scholar
  42. 42.
    Bannasch, P.: Carcinogenesis 7, 689 (1986).)PubMedCrossRefGoogle Scholar
  43. 43.
    Peraino, C., Fry, R. J. M., and Staffeldt, E.: Cancer Res. 31, 1506 (1971).PubMedGoogle Scholar
  44. 44.
    Peraino C., Fry, R. J. M., Staffeldt, E., and Christopher, E.: Cancer Res. 35, 2884 (1975).PubMedGoogle Scholar
  45. 45.
    Kunz, H. W., Schwarz, M, Tennekes, H., Port, R., and Appel, K. E.: Mechanism and Dose-Time Response Characteristics of Carcinogenic and Tumor Promoting Xenobiotics in Liver. In “Tumorpromotoren: Erkennung, Wirkungsmechanismen und Bedeutung” (K. E. Appel and A. G. Hildebrandt, eds.), BGA-Schriften 6, MMV Medizin. Verl., Munich, 1985, p. 76.Google Scholar
  46. 46.
    Kitagawa, T., and Sugano, H.: Gann 69, 679 (1978).PubMedGoogle Scholar
  47. 47.
    Schulte-Hermann, R., and Parzefall, W.: Cancer Res. 41, 4140 (1981).PubMedGoogle Scholar
  48. 48.
    Demi, E., and Oesterle, D.: Carcinogenesis 3, 1449 (1982).CrossRefGoogle Scholar
  49. 49.
    Jensen, R. K., Sleight, S. D., Goodman, J. I., Aust, S. D., and Trosko, J. E.: Carcinogenesis 3, 1183 (1982).PubMedCrossRefGoogle Scholar
  50. 50.
    Buchmann, A., Ziegler, S., Wolf, A., Robertson, L. W., Durham, S. K., Schwarz, M.: Toxicol. Appl. Pharmacol. III, 454 (1991).CrossRefGoogle Scholar
  51. 51.
    Pitot, H. C., Goldsworthy, T., Campbell, H. A., and Poland, A.: Cancer Res. 40, 3616 (1980).PubMedGoogle Scholar
  52. 52.
    Taper, H. S.: Cancer 42, 462 (1978).PubMedCrossRefGoogle Scholar
  53. 53.
    Yager, J. D., and Yager, R.: Cancer Res. 40, 3680 (1980).PubMedGoogle Scholar
  54. 54.
    Cameron, R. G., Imaida, K., Tsuda, H., and Ito, N.: Cancer Res. 42, 2426 (1982).PubMedGoogle Scholar
  55. 55.
    Yager, J. D., Campbell, H. A., Longnecker, D. S., Roebuck, B. D., and Benoit, M. C.: Cancer Res. 44, 3862 (1984).PubMedGoogle Scholar
  56. 56.
    Ochs, H., Düsterberg, B., Günzel, P., and Schulte-Hermann, R.: Cancer Res. 46, 1224 (1986).PubMedGoogle Scholar
  57. 57.
    Mochizuki, Y., Furukawa, K., and Sawada, N.: Carcinogenesis 3, 1027 (1982).PubMedCrossRefGoogle Scholar
  58. 58.
    Ward, J. M., Rice, J. M., Creasia, D., Lynch, P., and Riggs, D.: Carcinogenesis 4, 1021 (1983).PubMedCrossRefGoogle Scholar
  59. 59.
    Glauert, H. P., Beer, D., Rao, M. S., Schwarz, M., Xu, Y.-D., and Goldsworthy, T. L.: Cancer Res. 46, 4601 (1986).PubMedGoogle Scholar
  60. 60.
    Kraupp-Grasl, B., Huber, W., Putz, B., Gerbracht, U., and Schulte-Hermann, R.: Cancer Res. 50, 3701 (1990).PubMedGoogle Scholar
  61. 61.
    Tsuda, H., Masui, T., Imaida, K., Fukushima, S., and Ito, N.: Gann 75, 871 (1984).PubMedGoogle Scholar
  62. 62.
    Ito, N., Tsuda, H., Tatematsu, M., Inoue, T., Tagawa, Y., Aoki, T., Uwagawa, S., Kagawa, M., Osigo, T., Masui, T., Imaida, K., Fukushima, S., and Asamoto, M.: Carcinogenesis 9, 387 (1988).PubMedCrossRefGoogle Scholar
  63. 63.
    Dashwood, R. H., Fong, A. T., Williams, D. E., Hendricks, J. D., and Bailey, G. S.: Cancer Res. 51, 2362 (1991).PubMedGoogle Scholar
  64. 64.
    Dragani, T. A., Manenti, G., and Porta, G. D.: Cancer Lett. 31, 171 (1986).PubMedCrossRefGoogle Scholar
  65. 65.
    Columbano, A., Ledda-Columbano, G. M., Ennas, M. G., Curto, M., Chelo, A., and Pani, P.: Carcinogenesis 11, 771 (1990).PubMedCrossRefGoogle Scholar
  66. 66.
    Tanaka, T., Mori, H., and Williams, G. M.: Carcinogenesis 8, 1171 (1987).PubMedCrossRefGoogle Scholar
  67. 67.
    Demi, E., and Oesterle, D.: Cancer Lett. 29, 59 (1985).CrossRefGoogle Scholar
  68. 68.
    Columbano, A., Rajalakshmi, S., and Sarma, D. S. R.: Cancer Res. 41, 2079 (1981).PubMedGoogle Scholar
  69. 69.
    Schwarze, P. E., Petterson, E. O., Shoaib, M. C., and Seglen, P. O.: Carcinogenesis 5, 1267 (1984).PubMedCrossRefGoogle Scholar
  70. 70.
    Kuchlbauer, J., Romen, W., and Neumann, H.-G.: Carcinogenesis 9, 1337 (1985).CrossRefGoogle Scholar
  71. 71.
    Schwarz, M, Pearson, D., Port, R., and Kunz, W.: Carcinogenesis 5, 725 (1984).PubMedCrossRefGoogle Scholar
  72. 72.
    Rao, P. M., Nagamine, K., Ho, R.-K., Roomi, M. W., Laurier, C., Rajalakshmi, S., and Sarma, D. S. R.: Carcinogenesis 4, 1541 (1983).PubMedCrossRefGoogle Scholar
  73. 73.
    Hei, T. K., and Sudilovsky, O.: Cancer Res. 45, 2700 (1985).PubMedGoogle Scholar
  74. 74.
    Enzmann, H., Ohlhauser, D., Dettler, T., and Bannasch, P.: Carcinogenesis 10, 1247 (1989).PubMedCrossRefGoogle Scholar
  75. 75.
    Yokoyama, S., Sells, M. A., Reddy, T. V., and Lombardi, B.: Cancer Res. 45, 2834 (1985).PubMedGoogle Scholar
  76. 76.
    Pound, A. W., and McGuire, L. J.: Br. J. Cancer 37, 595 (1978).CrossRefGoogle Scholar
  77. 77.
    Hanigan, M. H., Winkler, M. L., and Drinkwater, N. R.: Carcinogenesis 11, 589 (1990).PubMedCrossRefGoogle Scholar
  78. 78.
    Preat, V. P., Pector, J. C., Taper, H., Lans, M., de Gelache, L., and Roberfroid, M.: Carcinogenesis 5, 1151 (1984).PubMedCrossRefGoogle Scholar
  79. 79.
    Nakanishi, K., Fukushima, S., Hagiwara, A., Tamano, S., and Ito, N.: J. Natl. Cancer. Inst. 68, 497 (1982).PubMedGoogle Scholar
  80. 80.
    Hiasa, Y., Kitahori, Y, Konishi, N., Enoki, N., and Fujita, T.: Carcinogenesis 4, 935 (1982)CrossRefGoogle Scholar
  81. 81.
    Diwan, B. A., Rice, J. M., Nims, R. W., Lubet, R. A., Hu, H., and Ward, J. M.: Cancer Res. 48, 2492 (1988).PubMedGoogle Scholar
  82. 82.
    Hirose, M., Shirai, T., Tsuda, H., Fukushima, S., Ogiso, T. and Ito, N.: Carcinogenesis 2, 1299 (1981).PubMedCrossRefGoogle Scholar
  83. 83.
    Silberhorn, E. M., Glauert, H. P., and Robertson, L. W.: CRC Crit. Rev. Toxicol. 20, 439 (1990).CrossRefGoogle Scholar
  84. 84.
    Poland, A., Palen, D., and Glover, E.: Nature 300, 271 (1982).PubMedCrossRefGoogle Scholar
  85. 85.
    Schulte-Hermann, R.: Arch. Toxicol. 57, 147 (1985).PubMedCrossRefGoogle Scholar
  86. 86.
    Palmer, A. E., Rice, J. M., Ward, J. M., Oshima, M., Cicmanek, J. L., Dove, L. F., and Lynch, P. H.: Proc. Am. Assoc. Cancer Res. 25, 560 (1984).Google Scholar
  87. 87.
    Lubet, R. A., Nims, R. W., Ward, J. M., Rice, J. M., and Diwan, B. A.: J. Am. Coll. Toxicol. 8, 259 (1989).Google Scholar
  88. 88.
    Stenbäck, F., Mori, H., Furuya, K., and Williams, G. M.: J. Natl. Cancer Inst. 76, 327 (1986).PubMedGoogle Scholar
  89. 89.
    Pereira, M. A., Knutsen, G. L., and Herren-Freud, S. L.: Carcinogenesis 6, 203 (1984).CrossRefGoogle Scholar
  90. 90.
    Pereira, M. A., Klaunig, J. E., Herren-Freud, S. L., and Ruch, R. J.: J. Natl. Cancer Inst. 77, 449 (1986).PubMedGoogle Scholar
  91. 91.
    Diwan, B. A., Rice, J. M., Oshima, M., and Ward, J. M.: Carcinogenesis 7, 215 (1986).PubMedCrossRefGoogle Scholar
  92. 92.
    Klaunig, J. E., Weghorst, C. M., and Pereira, M. A.: Toxicol. Appl. Pharmacol. 90, 79 (1987).PubMedCrossRefGoogle Scholar
  93. 93.
    Demi, E., and Oesterle, D.: Carcinogenesis 3, 1449 (1982).CrossRefGoogle Scholar
  94. 94.
    Kociba, R. J., Keyes, D. G., Beyer, J. E., Carreon, R. M., Wade, C. E., Dittenber, D. A., Kalnins, R. P., Frauson, L. E., Park, C. N., Barnard, S. D., Hummel, R. A., and Humiston, C. G.: Toxicol. Appl. Pharmacol. 46, 279 (1978).PubMedCrossRefGoogle Scholar
  95. 95.
    Lucier, G. W., Tritscher, A., Goldsworthy, T., Foley, J., Clark, G., Goldstein, J., and Maronpot, R.: Cancer Res. 51, 1391 (1991).PubMedGoogle Scholar
  96. 96.
    Weghorst, C. M., and Klaunig, J. E.: Carcinogenesis 10, 609 (1989).PubMedCrossRefGoogle Scholar
  97. 97.
    Drinkwater, N. R., Hanigan, M. H., and Kemp, C. J.: Genetic and Epigenetic Promotion of Murine Hepatocarcinogenesis. In “Mouse Liver Carcinogenesis: Mechanisms and Species Comparisons” (D. E. Stevenson, J. A. Popp, J. M. Ward, R. M. McClain, T. J. Slaga, and H. C. Pitot, eds.). Alan R. Liss, New York, 1990, p. 163.Google Scholar
  98. 98.
    Kemp, C. J., Leary, C. N., and Drinkwater, N. R.: Proc. Natl. Acad. Sci. U.S.A 86, 7505 (1989).PubMedCrossRefGoogle Scholar
  99. 99.
    Peraino, C., Fry, R. J. M., and Staffeldt, E.: J. Natl. Cancer Inst. 51, 1349 (1973).PubMedGoogle Scholar
  100. 100.
    Walker, A. I. T., Thorpe, E., and Stevenson, D. E.: Food Cosmet. Toxicol. 11, 415 (1973).PubMedCrossRefGoogle Scholar
  101. 101.
    Tomatis, L., Turosov, V., Day, N., and Charles, R. T.: Int. J. Cancer 10, 489 (1972).PubMedCrossRefGoogle Scholar
  102. 102.
    Rossi, L., Ravera, M., Repetti, G. and Santi, L.: Int. J. Cancer 19, 179 (1977).PubMedCrossRefGoogle Scholar
  103. 103.
    Becker, F. F.: Cancer Res. 45, 768 (1985).PubMedGoogle Scholar
  104. 104.
    Ashby, J.: Mutagenesis 1, 3 (1986).PubMedCrossRefGoogle Scholar
  105. 105.
    Fox, T. R., Schumann, A. M., Watanabe, P. G., Yano, B. L., Maher, V. M. and McCormick, J. J.: Cancer Res. 50, 4014 (1990).PubMedGoogle Scholar
  106. 106.
    Bauer-Hofmann, R., Buchmann, A., Mahr, J., Kress, S., and Schwarz, M.: Carcinogenesis 13, 477 (1992).PubMedCrossRefGoogle Scholar
  107. 107.
    Sargent, L. M., Sattler, G. L., Roloff, B., Xu, Y., Sattler, C. A., Meisner, L., and Pitot, H. C.: Cancer Res. 52, 955 (1992).PubMedGoogle Scholar
  108. 108.
    Wahba, Z. Z., Lawson, T. W., Murray, W. J., and Stohs, S. J.: Toxicology 58, 57 (1989).PubMedCrossRefGoogle Scholar
  109. 109.
    Rao, P. M., Rajalakshmi, S., Alam, A., Sarma, D. S. R., Pala, M. and Parodi, S.: Carcinogenesis 6, 765 (1985).PubMedCrossRefGoogle Scholar
  110. 110.
    Kasai, H., Okada, Y., Nishimura, S., Rao, M. S., and Reddy, J. K.: Cancer Res. 49, 2603 (1989).PubMedGoogle Scholar
  111. 111.
    Srinivasan, S., and Glauert, H. P.: Carcinogenesis 11, 2021 (1990).PubMedCrossRefGoogle Scholar
  112. 112.
    Schulte-Hermann, R., Timmermann-Trosiener, I., and Schuppler, J.: Cancer Res. 43, 839 (1983).PubMedGoogle Scholar
  113. 113.
    Popp, J. A., Scortichini, B. H., and Garvey, L. K.: Fund. Appl. Toxicol. 5, 314 (1985).CrossRefGoogle Scholar
  114. 114.
    Kraupp-Grasl, B., Huber, W., Taper, H., and Schulte-Hermann, R.: Cancer Res. 51, 666 (1991).PubMedGoogle Scholar
  115. 115.
    Ward, J. M.: J. Natl. Cancer Inst. 71, 815 (1983).PubMedGoogle Scholar
  116. 116.
    Ward, J. M., Diwan, B. A., Lubet, R. A., Hennemann, J. R., and Devor, D.: Liver Tumor Promoters and Other Mouse Carcinogens. In “Mouse Liver Carcinogenesis: Mechanisms and Species Comparisons” (D. E. Stevenson, J. A. Popp, J. M. Ward, R. M. McClain, T. J. Slaga, and H. C. Pitot, eds.). Alan R. Liss, New York, 1990, p 85.Google Scholar
  117. 117.
    Cattley, R. C., Marsman, D. S., and Popp, J. A.: Carcinogenesis 12, 469 (1991).PubMedCrossRefGoogle Scholar
  118. 118.
    Tennekes, H. A., van Ravenzwaay, B., and Kunz, H. W.: Carcinogenesis 6, 1457 (1985).PubMedCrossRefGoogle Scholar
  119. 119.
    Buchmann, A., Bauer-Hofmann, R., Mahr, J., Drinkwater, N. R., Luz, A., and Schwarz, M.: Proc. Natl. Acad. Sci. U.S.A. 88, 911 (1991).PubMedCrossRefGoogle Scholar
  120. 120.
    Goldsworthy, T., Campbell, H. A., and Pitot, H. C.: Carcinogenesis 5, 67 (1984).PubMedCrossRefGoogle Scholar
  121. 121.
    Campbell, H. A., Pitot, H. C., Potter, V. R., and Laishes, B. A.: Cancer Res. 42, 465 (1982).PubMedGoogle Scholar
  122. 122.
    Edwards, A. M., and Lucas, C. M.: Carcinogenesis 6, 733 (1985).PubMedCrossRefGoogle Scholar
  123. 123.
    Roomi, M. W., and Goldberg, D. M.: Biochem. Pharmacol. 30, 1563 (1981).PubMedCrossRefGoogle Scholar
  124. 124.
    Sirica, A. E., Jicinsky, J. K., and Heyer, E. K.: Carcinogenesis 5, 1737 (1984).PubMedCrossRefGoogle Scholar
  125. 125.
    Kunz, W., Schaude, G., and Thomas, C.: Z. Krebsforsch. 72, 291 (1969).PubMedCrossRefGoogle Scholar
  126. 126.
    Hoch-Ligeti, C., Argus, M. F., and Arcos, J. C.: J. Natl. Cancer. Inst. 40, 535 (1968).PubMedGoogle Scholar
  127. 127.
    McLean, A. E. M., and Marshall, A.: Br. J. Pathol. 52, 322 (1971).Google Scholar
  128. 128.
    Argus, M. F., Hoch-Ligeti, C., Arcos, J. C., and Conney, A. H.: J. Natl. Cancer Inst. 61, 441 (1978).PubMedGoogle Scholar
  129. 129.
    Lai, D. Y., Myers, S. C., Woo, Y.-T., Green, E. J., Friedman, M. A., Argus, M. F., and Arcos, J. C.: Chem.-Biol. Interact. 28, 107 (1979).PubMedCrossRefGoogle Scholar
  130. 130.
    Schwarz, M., Buchmann, A., Klormann, H., Schrenk, D., and Kunz, W.: Cancer Res. 45, 2020 (1985).PubMedGoogle Scholar
  131. 131.
    Schwarz, M., Bannasch, P., and Kunz, W.: Cancer Lett. 21, 17 (1983).PubMedCrossRefGoogle Scholar
  132. 132.
    Williams, G. M., and Furuya, K.: Carcinogenesis 5, 171 (1984).PubMedCrossRefGoogle Scholar
  133. 133.
    Peraino, C., Staffeldt, E., Heugen, D. A., Lombard, L. S., Stevens, F. J., and Fry, R. J. M.: Cancer Res. 40, 3268 (1980).PubMedGoogle Scholar
  134. 134.
    Moolgavkar, S. H., and Knudson A. G., Jr.: J. Natl. Cancer Inst. 66, 1037 (1981).PubMedGoogle Scholar
  135. 135.
    Moolgavkar, S. H.: Environ. Health Perspect. 50, 285 (1983).PubMedCrossRefGoogle Scholar
  136. 136.
    Schulte-Hermann, R., Timmermann-Trosiener, I., and Schuppler, J.: Carcinogenesis 7, 1651 (1986).PubMedCrossRefGoogle Scholar
  137. 137.
    Cohen, S. M., and Ellwein, L. B.: Science 249, 1007 (1990).PubMedCrossRefGoogle Scholar
  138. 138.
    Büsser, M.-T., and Lutz, W. K.: Carcinogenesis 8, 1433 (1987).PubMedCrossRefGoogle Scholar
  139. 139.
    Loury, D. J., Goldsworthy, T. L., and Butterworth, B. E.: The Value of Measuring Cell Replication as a Predictive Index of Tissue-Specific Tumorigenic Potential. In “Banbury Report 25: Nongenotoxic Mechanisms in Carcinogenesis” (B. E. Butterworth and T. J. Slaga, eds.). Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 1987, p. 119.Google Scholar
  140. 140.
    Butterworth, B. E., and Goldsworthy, T. L.: Proc. Soc. Exp. Biol. Med. 198, 683 (1991).PubMedGoogle Scholar
  141. 141.
    Yager, J. D., Zurlo, J., and Ni, N.: Proc. Soc. Exp. Biol. Med. 198, 667 (1991).PubMedGoogle Scholar
  142. 142.
    Pitot, H. C., Neveu, M. J., Hully, J. R., Rizvi, T. A., and Campbell, H.: Multistage Hepatocarcinogenesis in the Rat as a Basis for Models of Risk Assessment of Carcinogenesis. In “Scientific Issues in Quantitative Cancer Risk Assessment” (S. H. Moolgavkar, ed.). Birkhauser, Boston, 1990, p. 69.Google Scholar
  143. 143.
    Luebeck, E. G., Moolgavkar, S. H., Buchmann, A., and Schwarz, M.: Toxicol. Appl. Pharmacol. 111, 469 (1991)PubMedCrossRefGoogle Scholar
  144. 144.
    Farber, E., Parker, S., and Gruenstein, M.: Cancer Res. 36, 3879 (1976).PubMedGoogle Scholar
  145. 145.
    Farber, E.: Cancer Res. 28, 1859 (1968).PubMedGoogle Scholar
  146. 146.
    Roomi, M. W., Ho, R. K., Sarma, D. S. R., and Farber, E.: Cancer Res. 45, 564 (1985).PubMedGoogle Scholar
  147. 147.
    Buchmann, A., Schwarz, M., Schmitt, R., Wolf, C. R., Oesch, F., and Kunz, W.: Cancer Res. 47, 2911 (1987).PubMedGoogle Scholar
  148. 148.
    Kunz, H. W., Buchmann, A., Schwarz, M., Schmitt, R., Kuhlmann, W. D., Wolf, C. R., and Oesch, F.: Arch. Toxicol. 60, 198 (1987).PubMedCrossRefGoogle Scholar
  149. 149.
    Tsuda, H., Moore, M. A., Asomoto, M., Inoue, T., Fukushima, S., Ito, N., Satoh, K., Amelizad, Z., and Oesch, F.: Carcinogenesis 8, 711 (1987).PubMedCrossRefGoogle Scholar
  150. 150.
    Schwarz, M., Buchmann, A., Robertson, L., and Kunz, W.: Cell proliferation and hepatocarcinogenesis. In “Scientific Issues in Quantitative Cancer Risk Assessment” (S. H. Moolgavkar, ed.) Birkhäuser, Boston, 1990, p. 96.Google Scholar
  151. 151.
    Tsukuda, H., Sawada, N., Mitaka, T., and Gotoh, M.: Carcinogenesis 7, 335 (1986).CrossRefGoogle Scholar
  152. 152.
    Ames, B. N., and Gold, L. S.: Proc. Natl. Acad. Sci. U.S.A. 87, 7772 (1990).PubMedCrossRefGoogle Scholar
  153. 153.
    Kunz, W., Schaude, G., Schimmassek, H., Schmid, W., and Siess, M.: Proc. Eur. Soc. Study Drug Tox. VII (Exerpta Med. Int. Congr. Ser.) 115, 138 (1966).Google Scholar
  154. 154.
    Schulte-Hermann, R.: CRC Crit. Rev. Toxicol. 3, 97 (1974).PubMedCrossRefGoogle Scholar
  155. 155.
    Van Ravenszwaay, B., Tennekes, H., Stöhr, M., and Kunz, W.: Carcinogenesis 8, 265 (1987).CrossRefGoogle Scholar
  156. 156.
    Van Ravenszwaay, B., and Kunz, W.: Br. J. Cancer 58, 52 (1988).CrossRefGoogle Scholar
  157. 157.
    Yager, J. D., Roebuck, B. D., Paluszcyk, L., and Memoli, V. A.: Carcinogenesis 7, 2007 (1986).PubMedCrossRefGoogle Scholar
  158. 158.
    Marsman, D. S., Cattley, R. C., Conway, J. G., and Popp, J. A.: Cancer Res. 48, 6739 (1988).PubMedGoogle Scholar
  159. 159.
    Eacho, P. I., Lanier, T., and Brodhecker, C. A.: Carcinogenesis 12, 1557 (1991)PubMedCrossRefGoogle Scholar
  160. 160.
    Mayol, X., Perez-Tomas, R., Cullere, X., Romero, A., Estadella, M. D., and Domingo, J.: Carcinogenesis 12, 1133 (1991).PubMedCrossRefGoogle Scholar
  161. 161.
    Michalopoulos, G.: FASEB J. 4, 176 (1990).PubMedGoogle Scholar
  162. 162.
    Madhukar, B. V., Brewster, D. W., and Matsumura, F.: Proc. Natl. Acad. Sci. U.S.A. 81, 7407 (1984).PubMedCrossRefGoogle Scholar
  163. 163.
    Lin, F. H., Clark, G., Birnbaum, L. S., Lucier, G. W., and Goldstein, J. A.: Mol. Pharmacol. 39, 307 (1991).PubMedGoogle Scholar
  164. 164.
    Wolfe, D., Münzel, P., Fischer, G., and Bock, K. W.: Carcinogenesis 9, 919 (1988).CrossRefGoogle Scholar
  165. 165.
    Eckl, P. M., Meyer, S. A., Whitcombe, W. R., and Jirtle, R. L.: Carcinogenesis 9, 479 (1988).PubMedCrossRefGoogle Scholar
  166. 166.
    Lin, F. H., Stohs, S. J., Birnbaum, L. S., Clark, G., Lucier, G. W., and Goldstein, J. A.: Toxicol Appl. Pharmacol. 108, 129 (1991).PubMedCrossRefGoogle Scholar
  167. 167.
    Rubin, R. A., O’Keefe, E. J., and Earp, H. S.: Proc. Natl. Acad. Sci U.S.A. 79, 776 (1982)PubMedCrossRefGoogle Scholar
  168. 168.
    Harris, L., Preat, V., and Farber, E.: Cancer Res. 47, 3954 (1987).PubMedGoogle Scholar
  169. 169.
    Lee, L. S., and Weinstein, B.: Proc. Natl. Acad. Sci. U.S.A. 76, 5168 (1979).PubMedCrossRefGoogle Scholar
  170. 170.
    Shi, Y. E., and Yager, J. D.: Cancer Res. 49, 3574 (1989).PubMedGoogle Scholar
  171. 171.
    Yosof, Y. A. M., and Edwards, A. M.: Carcinogenesis 11, 761 (1990).CrossRefGoogle Scholar
  172. 172.
    Russell, W. E., Coffey, R. J., Ouellette, A. J. and Moses, H. L.: Proc. Natl. Acad. Sci. U.S.A. 85, 5126 (1988).PubMedCrossRefGoogle Scholar
  173. 173.
    Carr, B. I., Hayashi, I., Branum, E. L., and Moses, H. L.: Cancer Res. 46, 2330 (1986).PubMedGoogle Scholar
  174. 174.
    Oberhammer, F., Bursch, W., Parzefall, W., Breit, P., Stadler, M., and Schulte-Hermann, R.: Cancer Res. 51, 2478 (1991).PubMedGoogle Scholar
  175. 175.
    Oberhammer, F. A., Pavelka, M., Sharma, S., Tiefenbacher, R., Purchio, A. F., Bursch, W., and Schulte-Hermann, R.: Proc. Natl. Acad. Sci. U.S.A., 88, 5408 (1992).CrossRefGoogle Scholar
  176. 176.
    Bursch, W., Lauer, B., Timmermann-Trosiener, I., Barthel, G., Schuppler, J., and Schulte-Hermann, R.: Carcinogenesis 5, 453 (1984).PubMedCrossRefGoogle Scholar
  177. 177.
    Bursch, W., Paffe, S., Putz, B., Barthel, G., and Schulte-Hermann, R.: Carcinogenesis 11, 847 (1990).PubMedCrossRefGoogle Scholar
  178. 178.
    Columbano, A., Ledda-Columbano, G. M., Coni, P. P., Faa, G., Liguori, C., Santa Cruz, G., and Pani, P.: Lab. Invest. 52, 670 (1985).PubMedGoogle Scholar
  179. 179.
    Moolgavkar, S. H., Luebeck, G., and de Gunst, M.: Two Mutation Models for Carcinogenesis: Relative Roles of Somatic Mutations and Cell Proliferation in Determining Risk. In “Scientific Issues in Quantitative Cancer Risk Assessment” (S. H. Moolgavkar, ed.), Birkhauser, Boston, 1990, p. 136.Google Scholar
  180. 180.
    Trosko, J. E., and Chang, C.-C.: Nongenotoxic Mechanisms in Carcinogenesis: Role of Inhibited Intercellular Communication. In “Banbury Report 31: Carcinogen Risk Assessment: New Directions in the Qualitative and Quantitative Aspects” (R. W. Hart and F. D. Hoerger, eds.). Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 1988, p. 139.Google Scholar
  181. 181.
    Fitzgerald, D. J., and Yamasaki, H.: Terato. Carcino. Mutagen. 10, 89 (1990).CrossRefGoogle Scholar
  182. 182.
    Klaunig, J. E., and Ruch, R. J.: Lab. Invest. 62, 135 (1990).PubMedGoogle Scholar
  183. 183.
    Yamasaki, H.: Role of GAP Junctional Intercellular Communication in Malignant Cell Transformation. In “Modern Cell Biology: GAP Junctions” (E. L. Hertzberg and R. G. Johnson, eds.). Alan R. Liss, New York, 1988 p. 449.Google Scholar
  184. 184.
    Loewenstein W. R.: Biochim. Biophys. Acta 560, 1 (1979).PubMedGoogle Scholar
  185. 185.
    Enomoto, T., and Yamasaki, H.: Cancer Res. 44, 5200 (1984).PubMedGoogle Scholar
  186. 186.
    Yotti, L. P., Chang, C. C., and Trosko, J. E.: Science 206, 1089 (1979).PubMedCrossRefGoogle Scholar
  187. 187.
    Murray, A. W., and Fitzgerald, D. J.: Biochem Biophys. Res. Commun. 91, 395 (1979).PubMedCrossRefGoogle Scholar
  188. 188.
    Sugie, S., Mori, H., and Takahashi, M.: Carcinogenesis 8, 45 (1987).PubMedCrossRefGoogle Scholar
  189. 189.
    Klaunig, J. E., Ruch, R. J., and Weghorst, C. M.: Toxicol. Appl. Pharmacol. 102, 553 (1990).PubMedCrossRefGoogle Scholar
  190. 190.
    Flodstrom, S., Hemming, H., Wärngard, L., and Ahlborg, U. G.: Carcinogenesis 11, 1413 (1990).PubMedCrossRefGoogle Scholar
  191. 191.
    Jone, C., Trosko, J. E., and Chang, C. C.: In vitro Cell Develop. Biol. 23, 214 (1987).CrossRefGoogle Scholar
  192. 192.
    Tsushimoto, G., Trosko, J. E., Chang, C. C., and Aust, S. D.: Carcinogenesis 3, 181 (1982).PubMedCrossRefGoogle Scholar
  193. 193.
    Klaunig, J. E., Ruch, R. J., Deangelo, A. B., and Kaylor, W. H.: Cancer Lett. 43, 65 (1988).PubMedCrossRefGoogle Scholar
  194. 194.
    Schulz, N. E., Gray, T. J. B., and Klaunig, J. E.: Toxicologist 10, 122 (1989).Google Scholar
  195. 195.
    Lincoln D. W., II, Kampcik, S. J., and Gierthy, J. F.: Carcinogenesis 8, 1817 (1987).PubMedCrossRefGoogle Scholar
  196. 196.
    Jensen, R. K., and Sleight, S. D.: Carcinogenesis 7, 1771 (1986).PubMedCrossRefGoogle Scholar
  197. 197.
    Traub, O., Drüge, P. M., and Willecke, K.: Proc. Natl. Acad. Sci. USA 80, 755 (1983).PubMedCrossRefGoogle Scholar
  198. 198.
    Mesnil, M., Fitzgerald, D. J., and Yamasaki, H.: Mol. Carcinogenesis 1, 79 (1988).CrossRefGoogle Scholar
  199. 199.
    Beer, D. G., Neveu, M. J., Paul, D. L., Rapp, U. R., and Pitot, H. C.: Cancer Res. 48, 1610 (1988).PubMedGoogle Scholar
  200. 200.
    Klaunig, J. E.: Proc. Soc. Exp. Biol. Med. 198, 688 (1991).PubMedGoogle Scholar
  201. 201.
    Droga, S., Filser, J. G., Cojocel, C., Greim, H., Regel, U., Oesch, F., and Robertson, L. W.: Arch. Toxicol. 62, 369 (1988).CrossRefGoogle Scholar
  202. 202.
    Stohs, S. J., Hassan, M. Q., and Murray, W. J.: Biochem. Biophys. Res. Commun. 111, 854 (1983).PubMedCrossRefGoogle Scholar
  203. 203.
    Hildebrandt, A. G., Speck, M., and Roots, I.: Biochem. Biophys. Res. Commun. 54, 968 (1973).PubMedCrossRefGoogle Scholar
  204. 204.
    Goel, S. K., Lalwani, N. D., and Reddy, J. K.: Cancer Res. 46, 1324 (1986).PubMedGoogle Scholar
  205. 205.
    Reddy, J. K., and Lalwani; N. D.: CRC Crit. Rev. Toxicol. 12, 1 (1983).CrossRefGoogle Scholar
  206. 206.
    Reddy, J. K., and Rao, M. S.: Mutation Res. 214, 63 (1989).PubMedCrossRefGoogle Scholar
  207. 207.
    Robertson, L. W., Regel, U., Filser, J. G., and Oesch, F.: Arch. Toxicol. 57, 13 (1985).PubMedCrossRefGoogle Scholar
  208. 208.
    Nims, R. W., Devor, D. E., Hennemann, J. R., and Lubet, R. A.: Carcinogenesis 8, 67 (1987).PubMedCrossRefGoogle Scholar
  209. 209.
    Demi, E., Wiebel, F. J., and Oesterle, D.: Toxicology 59, 229 (1989).CrossRefGoogle Scholar
  210. 210.
    Schulte-Hermann, R., Ochs, H., Bursch, W., and Parzefall, W.: Cancer Res. 48, 2462 (1988).PubMedGoogle Scholar
  211. 211.
    Benedetti, A., Malvalsi, G., Fulceri, R., and Comporti, M.: Cancer Res. 44, 5712 (1984).PubMedGoogle Scholar
  212. 212.
    Rao, M. S., Lalwani, N. D., Scarpelli, D. G., and Reddy, J. K.: Carcinogenesis 3, 1231 (1982).PubMedCrossRefGoogle Scholar
  213. 213.
    Hanigan, M. H., and Pitot, H. C.: Carcinogenesis 6, 165 (1985).PubMedCrossRefGoogle Scholar
  214. 214.
    Demi, E., and Oesterle, D.: Cancer Res. 40, 490 (1980).Google Scholar
  215. 215.
    Stenius, U., Rubin, K., Gullberg, D., and Högberg, J.: Carcinogenesis 11, 69 (1990).PubMedCrossRefGoogle Scholar
  216. 216.
    Scholz, W., Schutze, K., Kunz, W., and Schwarz, M.: Cancer Res. 50, 7015 (1990).PubMedGoogle Scholar
  217. 217.
    Kuchino, Y., Mori, F., Kasai, H., Inoue, H., Iwai, S., Miura, K., Ohtsuka, E., and Nishimura, S.: Nature 327, 77 (1987).PubMedCrossRefGoogle Scholar
  218. 218.
    Pitot, H. C.: Proc. Soc. Exp. Biol. Med. 198, 661 (1991).PubMedGoogle Scholar
  219. 219.
    Pitot, H. C., Goldsworthy, T. L., Moran, S., Kennan, W.; Glauert, H. P., Maronpot, R. R., and Campbell, H. A.: Carcinogenesis 8, 1491 (1987).PubMedCrossRefGoogle Scholar
  220. 220.
    Moolgavkar, S. H., Luebeck, E. G., DeGunst, M., Port, R. E., and Schwarz, M.: Carcinogenesis 11, 1271 (1990).PubMedCrossRefGoogle Scholar
  221. 221.
    Oesterle, D., and Demi, E.: Carcinogenesis 5, 351 (1984).PubMedCrossRefGoogle Scholar
  222. 222.
    Takano, T., Tatematsu, M., Hasegawa, R., Imaida, K., and Ito, N.: Gann 71, 580 (1980).PubMedGoogle Scholar
  223. 223.
    Mochizuki, Y., Furukawa, K., Sawada, N., and Gotoh, M.: Gann 72, 170 (1981).PubMedGoogle Scholar
  224. 224.
    Maekawa, A., Onodera, H., Ogasawara, H., Matsushima, Y., Mitsumori, K., and Hayashi, Y.: Carcinogenesis 13, 501 (1992).PubMedCrossRefGoogle Scholar
  225. 225.
    Poland, A., Glover, E., and Kende, A. S.: J.Biol. Chem. 251, 4936 (1976).PubMedGoogle Scholar
  226. 226.
    Toft, D., Shyamala, G., and Gorski, J.: Proc. Natl. Acad. Sci. U.S.A. 57, 1740 (1967).PubMedCrossRefGoogle Scholar
  227. 227.
    Issemann, I., and Green, S.: Nature 347, 645 (1990).PubMedCrossRefGoogle Scholar
  228. 228.
    Lutz, W. K.: Carcinogenesis 11, 1243 (1990).PubMedCrossRefGoogle Scholar
  229. 229.
    Peraino, C., Fry, R. I. M., and Staffeldt, E.: Cancer Res. 37, 3623 (1977).PubMedGoogle Scholar
  230. 230.
    Preat, V., Lans, M., de Gerlache, J., Taper, H., and Roberfroid, M.: Carcinogenesis 8, 333 (1987).PubMedCrossRefGoogle Scholar
  231. 231.
    Jensen, R. K., Sleight, S. D., and Aust, S. D.: Carcinogenesis 5, 63 (1984).PubMedCrossRefGoogle Scholar
  232. 232.
    Bout well, R. K.: Progr. Exp. Tumor Res. 4, 207 (1964).Google Scholar
  233. 233.
    Boutwell, R. K.: CRC Crit. Rev. Toxicol. 2, 419 (1974).PubMedCrossRefGoogle Scholar
  234. 234.
    Tatematsu, M., Nagamine, Y., and Farber, E.: Cancer Res. 43, 5049 (1983).PubMedGoogle Scholar
  235. 235.
    Moore, M., Hacker, H.-J., and Bannasch, P.: Carcinogenesis 4, 595 (1983).PubMedCrossRefGoogle Scholar
  236. 236.
    Glauert, H. P., Schwarz, M., and Pitot, H. C.: Carcinogenesis 7, 117 (1986).PubMedCrossRefGoogle Scholar
  237. 237.
    Kitagawa, T.: Gann 62, 207 (1971).PubMedGoogle Scholar
  238. 238.
    Enomoto, K., and Farber, E.: Cancer Res. 42, 2330 (1982).PubMedGoogle Scholar
  239. 239.
    Hendrich, S., Glauert, H. P., and Pitot, H. C.: Carcinogenesis 7, 2041 (1986).PubMedCrossRefGoogle Scholar
  240. 240.
    Xu, Y.-D., Dragan, Y. P., Young, T., and Pitot, H. C.: Carcinogenesis 12, 1009 (1991).PubMedCrossRefGoogle Scholar
  241. 241.
    Fingerhut, M. A., Halperin, W. E., Marlow, D. A., Piacitelli, L. A., Honchar, P. A., Sweeney, M. H., Greife, A. L., Dill, P. A., Steenland, K., and Suruda, A. J.: New Engl. J. Med. 324, 212 (1991).PubMedCrossRefGoogle Scholar
  242. 242.
    Johnson, E. S.: Toxicology 21, 451 (1992).Google Scholar
  243. 243.
    Clemmensen, J., Fuglsang, V., and Plum, C. M.: Lancet 1, 705 (1977).Google Scholar
  244. 244.
    Ohlsen, J. H., Boice, J. D., Jr., Jensen, J. P. A., and Fraumeni, J. F., Jr.: J. Natl. Cancer Inst. 81, 803 (1989).CrossRefGoogle Scholar
  245. 246.
    McLean, E. M., Driver, H., and McDanell, R.: Bull. Cancer 77, 505 (1990).PubMedGoogle Scholar
  246. 247.
    Stott, W. T.: Reg. Toxicol. Pharmacol. 8, 125 (1988).CrossRefGoogle Scholar
  247. 248.
    Baum, J., Holtz, F., Bookstein, J. J., and Klein, E. W.: Lancet 2, 926 (1973).PubMedCrossRefGoogle Scholar
  248. 249.
    Edmondson, H. A., Henderson, B., and Benton, B.: New Engl. J. Med. 249, 470 (1976).CrossRefGoogle Scholar
  249. 250.
    Palmer, J. R., Rosenberg, L., Kaufmann, D. W., Warshauer, M. E., Stolley, P., and Sharpiro, S.: Am. J. Epidemiol. 130, 878 (1989).PubMedGoogle Scholar
  250. 251.
    Edmondson, H. A., Reynolds, T. B., Henderson, B., and Benton, B.: Ann. Int. Med. 86, 180 (1977).PubMedGoogle Scholar
  251. 252.
    Parkin, D. M., Läära, E., and Muir, C. S.: Int. J. Cancer 41, 184 (1988).PubMedCrossRefGoogle Scholar
  252. 253.
    Bosch, F. X., and Munoz, N.: Epidemiology of Hepatocellular Carcinoma. In “Liver Cell Carcinoma” (P. Bannasch, D. Keppler, and G. Weber, eds.). Kluwer Academic Publishers, Dordrecht, 1988, p. 3.Google Scholar
  253. 254.
    Bressac, B., Key, M., Wands, J., and Oztürk, M.: Nature 350, 429 (1991).PubMedCrossRefGoogle Scholar
  254. 255.
    Hsu, I. C., Metcalf, R. A., Sun, T., Welsh, J. A., Wang, N. J., and Harris, C. C.: Nature 350, 427 (1991).PubMedCrossRefGoogle Scholar
  255. 256.
    Oztürk, M.: Lancet 338, 1356 (1991).PubMedCrossRefGoogle Scholar
  256. 257.
    Chisari, F. V., Klopchin, K., Moriyama, T., Pasquinelli, C., Dunsford, H. A., Sell, S., Pinkert, C. A., Brinster, R. L., and Palmiter, R. D.: Cell 59, 1145 (1989).PubMedCrossRefGoogle Scholar
  257. 258.
    Lieber, C. S., Garro, A., Leo, M. A., Mak, K. M., and Worner, T.: Hepatology 6, 1005 (1986).PubMedCrossRefGoogle Scholar
  258. 259.
    Niederau, C., Fisher, R., Sonneberg, A., Stremmel, W., Trampisch, H. J., and Strohmeyer, G.: N. Engl. J. Med. 313, 1256 (1985).PubMedCrossRefGoogle Scholar
  259. 260.
    Melia, W. M., Johnson, P. J., and Neuberger, J.: Gastroenterology 87, 660 (1984).PubMedGoogle Scholar
  260. 261.
    Masuda, R., Yoshida, M. C., Sakai, M., Dempo, K., and Mori, M.: High Susceptibility to Spontaneous Development of Hepatocellular Carcinoma in LEC rats. In “The LEC Rat” (M. Mori, M. C. Yoshida, N. Takeichi, and N. Taniguchi, eds.). Springer Verlag, Tokyo, 1991, p. 54.Google Scholar

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© Birkhäuser Boston 1995

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  • Michael Schwarz

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