Oncogenes in Acute Myelogenous Leukemia

  • Robert Peter Gale
  • Anna Butturini
Conference paper
Part of the Experimental Hematology Today—1987 book series (HEMATOLOGY, volume 1987)

Abstract

Normal eukaryotic DNA contain a family of genes termed proto-oncogenes thought to regulate normal cell growth and development (1). Expression of viral analogues of cellular proto-oncogenes in the context of acutely transforming retroviruses, is responsible for neoplastic transformation. Possible mechanisms by which viral or cellular oncogenes can cause neoplastic transformation have been recently reviewed (2,3). Since qualitative and quantitative alterations of oncogene expression can result in neoplastic transformation in experimental models, expression of cellular oncogenes in human leukemias is the subject of intense investigation. Recently we reviewed the role of oncogenes in human leukemias (4). In this review we focus on oncogene abnormalities in acute myeloid leukemia (AML).

Keywords

Acute Myelogenous Leukemia Acute Myeloid Leukemia Cell Acute Myeloblastic Leukemia Myeloid Leukemia Cell Line Cellular Oncogene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag New York Inc. 1988

Authors and Affiliations

  • Robert Peter Gale
  • Anna Butturini

There are no affiliations available

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