Kinetic—Structural Organization of Enzyme Systems

  • B. N. Goldstein
Chapter

Abstract

Many enzyme systems respond to chemical signals (substrates or effectors) by drastically changing their activities. Two phenomena are essential in this kinetic behavior: cooperativity of oligomeric enzymes and covalent modification of enzymes (1–3). Both phenomena can be easily understood from the structure of the kinetic schemes using graph-theoretical methods (4). This chapter is concerned with two applications of the graph-theoretical method: (a) cooperative equilibrium ligand—enzyme interactions; and (b) multiple steady-state transitions in phosphorylated enzyme systems.

Keywords

Enzyme System Critical Phenomenon Kinetic Scheme Saturation Function Initial Node 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag New York Inc. 1988

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  • B. N. Goldstein

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