Anti-Idiotypes, Receptors, and Molecular Mimicry pp 255-266 | Cite as
Anti-Idiotypes and Lymphokine Receptors: Interferon as a Model
Abstract
Anti-idiotypic antibodies have been used as cell surface receptor probes in a number of systems (for a review, see Ref. 1). However, there have been relatively few reports which describe monoclonal anti-idiotypic antibodies that not only recognize the receptors specific for a protein or polypeptide but also trigger the known biological activity of that protein or polypeptide. The biological and potential clinical significance of various lymphokines and the generally low level of expression of cellular receptors for these biologically active proteins make the study of anti-idiotypes as probes for these lymphokine receptors especially interesting and important. The successful cloning of various human interferon cDNAs and their expression in bacteria (for a review, see Ref. 2), coupled with recent reports showing direct analysis of interferon binding to specific cellular receptors (for a review, see Ref. 3), enabled us to use the recombinant human leukocyte A interferon (rIFN-aA) as a model system to study the anti-idiotypes as interferon receptor probes. This model system can be applied to studies of receptors for other lymphokines or biologically active proteins.
Keywords
Antiviral Activity Receptor Binding Site Human Interferon MDBK Cell Normal Mouse SerumPreview
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