Abstract
Among the serologically defined DR2 (DRw15) cluster, two distinct haplotypes, Dw2 and Dw12, have been recognized since the Eighth International Workshop. These two haplotypes differ by at least three amino acids in one of their DRβ molecules and by at least one amino acid in the second DRβ chain. Although Dw2 and Dw12 are both associated with the DQw6 subtype of DQw1, they nevertheless exhibit multiple amino acid differences in their DQβ chains (1) and have distinct DQα chains (2). A third DR2-associated specificity, which is distinct from Dw2 and Dw12, has been designated LD-2s since cells with this specificity have been associated with the “DR2 short” serologic specificity, now designated DRwl6. This specificity has been designated MN2, FJO, AZH, and WT24 in various reports (3) and is now designated Dw21. LD-5a is a related specificity which is also associated with the DR2 short-DRw16 specific ity (4) and is now designated Dw22. Sequence analysis has demonstrated that one DRβ chain is identical in cells typing as Dw21 and Dw22 (but differs by at least five amino acids from each of the DRw15 haplotypes) (1,5).
Participating Laboratories: USIBAC,1 US2MBC,2 NCYZIE,3 BENROO,4 US1DUQ,5 US7NFL6
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References
Gregersen PK, Todd JA, Erlich HA, Long E, Servenius B, Choi E, et al. First domain sequence diversity of DR and DQ subregion alleles. In: Dupont B (ed): Immunobiology of HLA, Volume I: Histocompatibility Testing 1987. New York: Springer-Verlag, 1989.
Kaplan C, Morel MC, Hermans P, Tkaczuk J, Naskatsuji T, Fernandez N, et al. DQwl (DQw5, DQw;6): 2-D gel patterns. In: Dupont B (ed): Immunobiology of HLA, Volume I: Histocompatibility Testing 1987. New York: Springer-Verlag, 1989.
Reinsmoen NL, Layrisse Z, Betuel H, Freidel AC, Bach FH. A study of HLA-DR2 associated HLA-Dw/LD specificities. Hum Immunol 1984;11:105–115.
Layrisse Z, Simoney N, Park MS, Terasaki PI. HLA-D and DRw determinants in an American indigenous isolate. Transplant Proc 1979;11:1788–1791.
Liu CP, Wu S, Bach FH. Molecular studies of the rare DR2/LD51 /DQw3 haplotype: Implications for mechanisms of generating HLA class II polymorphisms. In: Dupont B (ed): Immunobiology of HLA, Volume II: Immunogenetics and Histocompatibility. New York: Springer-Verlag, 1989.
Rust N, Carter C, Fuggle S, Sacks S, Hermans P, Charron D, et al. DR2 (DRw15,16): 2-D gel patterns. In: Dupont B (ed): Immunobiology of HLA, Volume I: Histocompatibility Testing 1987. New York: Springer-Verlag, 1989.
Bidwell JL, Bidwell EA, Savage D, Middleton D, Cullen C, Klouda PT, et al. Identification of Dw2, Dwl2 and short DR2 splits with sequential exon-specific DRbeta, DQbeta and DQalpha cDNA probes. In: Dupont B (ed): Immunobiology of HLA, Volume II: Immunogenetics and Histocompatibility. New York: Springer-Verlag, 1989.
Bignon JD, Semana G, Tiercy JM, Simons M, Lalouel JM, Cohen D. DNA-RFLP analysis: HLA-DR beta workshop report. In: Dupont B (ed): Immunobiology of HLA, Volume I: Histocompatibility Testing 1987. New York: Springer-Verlag, 1989.
Oudshoorn M, Du Toit ED, Martell RW, Taljaard DG. The heterogeneity of HLA-DR2. In: Dupont B (ed): Immunobiology of HLA, Volume II: Immunogenetics and Histocompatibility. New York: Springer-Verlag, 1989.
Reinsmoen NL, Bach FH. T-cell clonal analysis of HLA- DR2 haplotypes. Hum Immunol 1987;20:13–32.
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Reinsmoen, N. et al. (1989). DR2: Antigen Report of the Cellular Studies of the Tenth International Histocompatibility Workshop. In: Dupont, B. (eds) Immunobiology of HLA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3552-1_104
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DOI: https://doi.org/10.1007/978-1-4612-3552-1_104
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