Abstract
Catecholamines, particularly dopamine (DA) and norepinephrine (NE), generally are considered to be the principal amine neurotransmitters and/ or neuromodulators in the carotid body (CB) (1,2). The role of DA in the regulation of CB chemoreceptor activity and its effects on respiration have been well documented (1–4). On the other hand, information on 5-hydroxytryptamine (5-HT, serotonin) previously shown to be present in CB is relatively scanty and its role in chemoreception has not been defined yet (5–7). Recent studies by our group have shown that 5-HT appears to be the amine in highest concentration in the human infant CB (5). In order to investigate this finding further, the present study was conducted. A combination of biochemical and immunohistochemical methods was used to analyze and compare the 5-HT, DA, and NE content of CB from infants who died of various disease states. These included cases of acute death, usually traumatic (controls), Sudden Infant Death Syndrome (SIDS), congenital heart disease (CHD), and chronic pulmonary disease (CPD).
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Perrin, D.G., Chan, W., Newman, C., Cutz, E. (1990). Serotonin in the Human Infant Carotid Body: Normal and Pathological States. In: Eyzaguirre, C., Fidone, S.J., Fitzgerald, R.S., Lahiri, S., McDonald, D.M. (eds) Arterial Chemoreception. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3388-6_52
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DOI: https://doi.org/10.1007/978-1-4612-3388-6_52
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