Lipoprotein and Lipid Metabolism: Basic and Clinical Aspects

  • David A. Chappell
  • Arthur A. Spector
Chapter

Abstract

Lipoproteins are complexes of lipid and specialized proteins called apoproteins. Apoproteins have physical properties that allow them to bind lipids that are insoluble in water and transport them in the plasma and interstitial fluid. The lipids consist of phospholipids and cholesterol, which are required for cell membrane synthesis, and triglycerides, which are the primary form of energy storage in mammals. In addition, cholesterol is a precursor for steroid hormone and bile acid synthesis. Lipoproteins are synthesized predominantly in two tissues, the liver and the intestine. Upon entering the circulation, lipoproteins undergo a complicated series of modifications. Abnormalities in the synthesis or metabolism of lipoproteins may lead to hyperlipidemia and accelerated atherosclerosis.

Keywords

Cholesteryl Ester High Density Lipoprotein Plasma Lipoprotein Reverse Cholesterol Transport Hepatic Lipase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer-Verlag New York Inc. 1991

Authors and Affiliations

  • David A. Chappell
  • Arthur A. Spector

There are no affiliations available

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