Molecular Cytogenetic Stratification of Renal Cell Tumors

  • Gyula Kovacs
Conference paper

Abstract

The incidence of renal cell carcinoma in the population is 5–10 per 100,000. There is no satisfactory screening method for early detection. About 40% of the patients have metastatic disease at the time of diagnosis and one-third of the remainder will develop distant metastases during the postoperative course. The most effective therapy for RCC localized to the kidney is surgery, whereas a metastatic tumor is practically incurable. The overall response to biological response modifiers is low and the treatment is only palliative in the vast majority of cases. The goal of future therapy is to target specific tumor suppressor genes and other tumor-related genes. Therefore, it is important that genetics be incorporated into the evaluation of renal cell neoplasms in an attempt to provide a foundation for an appropriate diagnosis and selective treatment.

Keywords

Renal Cell Carcinoma Renal Cell Papillary Renal Cell Carcinoma Metastatic Growth Chromophobe Renal Cell Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag New York Inc. 1995

Authors and Affiliations

  • Gyula Kovacs
    • 1
  1. 1.Laboratory of Molecular Oncology, Department of UrologyRuprecht-Karls University of HeidelbergHeidelbergGermany

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