The Testis pp 43-54 | Cite as

Regulation of the Differentiation of the Undifferentiated Spermatogonia

  • Dirk G. de Rooij
  • Bianca H. G. J. Schrans-Stassen
  • Ans M. M. van Pelt
  • Gladis A. Shuttlesworth
  • Marvin L. Meistrich
  • Masaru Okabe
  • Yoshitake Nishimune
Part of the Serono Symposia USA book series (SERONOSYMP)


In the seminiferous epithelium of adult nonprimate mammals, so-called A-single (As) spermatogonia are the stem cells of spermatogenesis (1–3). Upon division of the As spermatogonia, the daughter cells either migrate away from each other and become two new stem cells, or the cells stay together becoming A-paired (Apr) spermatogonia connected by an intercellular bridge. About half of the stem-cell population normally divides to form Apr spermatogonia, whereas the other half goes through self-renewing divisions, thereby maintaining stem-cell numbers (Fig. 5.1).


Sertoli Cell Stem Cell Factor Seminiferous Epithelium Spermatogonial Stem Cell Intercellular Bridge 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag New York, Inc. 2000

Authors and Affiliations

  • Dirk G. de Rooij
  • Bianca H. G. J. Schrans-Stassen
  • Ans M. M. van Pelt
  • Gladis A. Shuttlesworth
  • Marvin L. Meistrich
  • Masaru Okabe
  • Yoshitake Nishimune

There are no affiliations available

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