Hormonal Carcinogenesis III pp 444-450 | Cite as
Evidence for an Initiation Mechanism of 17β-Estradiol Carcinogenesis
Conference paper
Summary
17β-estradiol (E2), the endogenous female hormone, is carcinogenic causing uterine and breast cancers. The mechanism is unknown. We found that E2 could be activated by the epoxide-forming oxidant dimethyldioxirane (DMDO) and proposed that E2 epoxidation is the mechanism of E2 carcinogenesis. One of the critical tests of our hypothesis is to determine whether E2 -DNA adducts are formed in vivo. When female ACI rats were given intramammillary injections of E2 and DMDO-activated E2, identical DNA adducts were formed. However, the activated E2 was at least 25,000-fold more active than E2 forming DNA adducts in vivo.
Keywords
Mammary Gland Initiation Mechanism Cerenkov Counting Female Mammary Gland Tubing Implant
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© Springer-Verlag New York, Inc. 2001