The Pressor Effect of Hemoglobin-Good or Bad?

  • Robert J. Przybelski
  • Elaine K. Daily
  • B. S. FCCM
  • Marvin L. Birnbaum
Chapter

Abstract

When Bayliss infused hemolyzed blood into cats 75 years ago, he found that solution to “raise blood pressure, if it was low, and increase the secretion of urine” (Bayliss 1920) Amberson further explored this “vasoconstrictor action of dissolved hemoglobin,” finding that infusions of hemoglobin “always raise the blood pressure” (Amberson 1937). He stated that in the case of large-volume infusions into animals “this pressor action may be ascribed in part to the high colloidal osmotic pressure of hemoglobin-saline solutions which draw fluid into the blood and so raise its volume.” But even when small volumes were infused into humans, he “usually observed an elevation in blood pressure,” concluding that “a chemical pressor effect is also present” (Amberson, Jennings and Rhodes 1949).

Keywords

Pressor Effect Hemorrhagic Shock Total Peripheral Resistance Regional Blood Flow Base Deficit 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Robert J. Przybelski
  • Elaine K. Daily
  • B. S. FCCM
  • Marvin L. Birnbaum

There are no affiliations available

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