Muscle Metabolism in the Fetus and Neonate

  • Ulrich A. Walker
  • Armand F. Miranda
Chapter

Abstract

Skeletal muscle is derived from the mesoderm. Myogenesis involves a continuous and dynamic series of biosynthetic and restructuring events that result in the molding of fetal tissue, ultimately leading to adult muscle with its distinct metabolic, structural, and functional properties. During myogenesis many individual enzymes and structural proteins are replaced by other variants (i.e., isoforms), with modulated metabolic capabilities. The myogenic process is highly conserved in evolution. It involves the orderly expression of myogenic regulatory factors that act in concert with nonmyogenic tissue components, including the interaction with a competent nerve supply. The development of muscle is further complicated because it is a very heterogeneous tissue. Additional specific genetically regulated control elements are involved in the production and maintenance of functionally diverse muscle groups. During the past decade a wealth of new information has been gathered at the molecular level that sheds new light on the intricate genetic regulation of muscle cell commitment, development of muscle cell diversity, and muscle maturation. Most noteworthy is the discovery of several muscle regulatory genes, that can switch on the myogenic process in pluripotent cells.

Keywords

Skeletal Muscle Creatine Kinase Satellite Cell Myosin Heavy Chain Human Skeletal Muscle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Ulrich A. Walker
  • Armand F. Miranda

There are no affiliations available

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