Reactive Oxygen Species in Clinical Practice

  • Aruna Nathan
  • Mervyn Singer


Reactive oxygen species (ROSs) are oxidants produced in both health and disease by various processes, for example, from the phagocytic respiratory burst, during mitochondrial aerobic respiration, and as a by-product of both ischemia and reper-fusion. In health, ROSs serve a variety of roles, including defense, cell signaling, and as a trigger for inflammation (Fig.18.1).A number of endogenous mechanisms are in place to protect the body against excessive oxidant effect, including circulating antioxidants (e.g., albumin) intracellular antioxidants (e.g., reduced glutathione), and specific enzymes (e.g., superoxide dismutase)(Table 18.1).When the equilibrium is grossly disrupted by excess production of oxidants or loss of endogenous defenses, widespread damage can ensue to protein, lipid, DNA, and mitochondria.This damage is implicated in various local or systemic clinical syndromes, such as after reperfusion of an ischemic heart, limb, or bowel, or with acute respiratory distress syndrome (ARDS) or sepsis.


Reactive Oxygen Species Nitric Oxide Acute Lung Injury Acute Respiratory Distress Syndrome Xanthine Oxidase 
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© Springer Science+Business Media New York 2000

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  • Aruna Nathan
  • Mervyn Singer

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