Goodpasture Syndrome: Molecular Architecture and Function of Basement Membrane Antigen

  • Billy G. Hudson
  • Jörgen Wieslander
  • Billie J. WisdomJr.
  • Milton E. Noelken
Chapter

Abstract

In studies of victims from the influenza pandemic of 1918–1919, Ernest Goodpasture described the coexistence of fatal pulmonary hemorrhage and proliferative glomerulonephritis in a young man (25). The term Good- pasture syndrome was coined by Stanton and Tange in 1958 to describe cases characterized by the coexistence of these manifestations (73). The syndrome is now defined as an autoimmune disorder consisting of the triad of glomerulonephritis, lung hemorrhage, and antiglomerular basement membrane antibody formation, and it includes a broad spectrum of clinical features, ranging from massive pulmonary hemorrhage with little overt evidence of renal disease to fulminant crescentic glomerulonephritis and little overt evidence of pulmonary hemorrhage (24). Although the etiology of this syndrome remains unknown, profound advances have been made during the last 25 years in delineating the pathogenesis of the glomerulonephritis.

Keywords

Basement Membrane Glomerular Basement Membrane Basement Membrane Collagen Antiglomerular Basement Membrane Goodpasture Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Billy G. Hudson
    • 1
    • 2
  • Jörgen Wieslander
    • 1
    • 2
  • Billie J. WisdomJr.
    • 1
    • 2
  • Milton E. Noelken
    • 1
    • 2
  1. 1.Department of Biochemistry and Molecular BiologyUniversity of Kansas Medical CenterKansas CityUSA
  2. 2.Department of NephrologyUniversity of LundLundSweden

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