Molecular Basis of Neurologic Disorders Induced by a Mutant, ts1, of Moloney Murine Leukemia Virus

  • Paul K. Y. Wong
  • P. H. Yuen
Chapter

Abstract

The consequences of retrovirus infection range widely. In some instances, infection induces cellular proliferation that can result in neoplasia, whereas in other cases, infection results in cell killing leading to degenerative diseases. The Moloney murine leukemia (MoMuLV) system is a good example of this diverse effect of retroviruses on the infected host. Although MoMuLV primarily causes T-cell lymphoma (1, 2, 3), several temperature-sensitive (ts) mutants of MoMuLV have been shown to cause degenerative disorders of the nervous system (4, 5, 6). One of these ts mutants, designated ts1 , has been studied most intensively. ts1 was the first neurovirulent retrovirus to be isolated in vitro from a nonneurovirulent MuLV (7). Prior to the isolation of ts1 , naturally occurring neurovirulent MuLVs had been isolated from wild mice (8). A discussion of a naturally occurring neurovirulent MuLV is given in the chapter by Jolicoeur, Gravel, and Kay in this book. Neurovirulent or neurotropic MuLVs have also been generated from nonneurovirulent strains of MuLV by passaging MuLVs in cells or animals or by manipulating the viruses in vitro (4, 9, 10, 11, 12, 13).

Keywords

Human Immunodeficiency Virus Type Envelope Protein Murine Leukemia Virus Envelope Glycoprotein Neurologic Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Paul K. Y. Wong
  • P. H. Yuen

There are no affiliations available

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