Alcohol and Hormones pp 1-20 | Cite as
Pattern of Hormonal Response to Chronic Ethanol Ingestion During Puberty
Abstract
Although alcohol use among youth has decreased over the last 10 yr,1 it still remains substantial.2In 1987, this country contained over 300,000 alcoholics between the ages of 13 and 17 yr.3Several thousand students participated in a national survey conducted in 1990. Over 50% of 13-yr-old boys had consumed alcohol during the previous 30-d period. Nearly 30% reported heavy drinking during this period (≤5 drinks/occasion), and over one-third of 9th graders reported alcohol use before the age of 12.4In other countries, problems related to alcohol use among youth may be greater; nearly one-third of Swedish children recently hospitalized for acute alcohol intoxication were under 8 yr old.5 A study of male French adolescents revealed regular alcohol consumption by 28% of boys aged 13-14 yr. Six percent of this age group consumed more than 1 drink/d.6The prevalence of alcohol use among youth as a function of age has been compared to the spread of an epidemic disease.7
Keywords
Luteinizing Hormone Sertoli Cell Leydig Cell Pubertal Development Chronic EthanolPreview
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References
- 1.G. M. Barnes, J. W. Weite, and B. A. Dintcheff (1993) Decline in alcohol use among 7–12th grade students in New York State, 1983–1990.Alcohol. Clin. Exp. Res.17, 797–801.PubMedCrossRefGoogle Scholar
- 2.J. S. Ehrman (1992) Survey finds alcohol use common in youngsters.ADAMHA News18, 17–19.Google Scholar
- 3.J. Kinney and G. Leaton (1987)Loosening the Grip: A Handbook of Alcohol Information.C.V. Mosby, St. Louis.Google Scholar
- 4.Division of Epidemiology and Prevention Research, NIDA/ADAMHA (1991) Alcohol and other drug use among high school students-United States, 1990.JAMA266, 3266–3267.CrossRefGoogle Scholar
- 5.M. Thunstrom (1988) The alcohol intoxicated child and its prognosis.Acta Paediatr. Scand.77, 3–9.PubMedCrossRefGoogle Scholar
- 6.J. Weill and B. Le Bourhis (1991) The amount of alcohol intake and some associated factors in a representative sample of 691 French boys aged 13–18.Drug Alcohol Depend.28, 183–187.PubMedCrossRefGoogle Scholar
- 7.D. C. Rowe and J. L. Rodgers (1991) Adolescent smoking and drinking: are they “epidemics”?J. Stud. Alcohol52, 110–117.PubMedGoogle Scholar
- 8.G. Van Vliet (1991) Clinical aspects of normal pubertal development.Hormone Res.36, 93–96.PubMedCrossRefGoogle Scholar
- 9.A. M. Symons and V. Marks (1975) The effects of alcohol on weight gain and the hypothalamic-pituitary-gonadotrophin axis in the maturing male rat.Biochem. Pharmacol.24, 955–958.PubMedCrossRefGoogle Scholar
- 10.T. J. Cicero, M. L. Adams, L. O’Connor, B. Nock, E. R. Meyer, and D. Wozniak (1990) Influence of chronic alcohol administration on representative indices of puberty and sexual maturation in male rats and the development of their progeny.J. Pharmacol. Exp. Ther.255, 707–715.PubMedGoogle Scholar
- 11.J. A. Ramaley (1982) The regulation of gonadotrophin secretion in immature ethanol-treated male rats.J. Androl.3, 248–255.Google Scholar
- 12.R. A. Anderson, S. H. Berryman, J. F. Phillips, K. A. Feathergill, L. J. D. Zaneveld, and L. D. Russell (1989) Biochemical and structural evidence for ethanol-induced impairment of testicular development: apparent lack of Leydig cell involvement.Toxicol. Appl. Pharmacol. 100 62–85. Google Scholar
- 13.R. A. Anderson, B. R. Willis, J. F. Phillips, C. Oswald, and L. J. D. Zaneveld (1987) Delayed pubertal development of the male reproductive tract associated with chronic ethanol ingestion.Biochem. Pharmacol.36, 2157–2167.PubMedCrossRefGoogle Scholar
- 14.R. A. Anderson, B. R. Willis, C. Oswald, and L. J. D. Zaneveld (1983) Male reproductive tract sensitivity to ethanol: a critical overview.Pharmacol. Biochem. Behay.18 (Suppl. 1), 305–310.CrossRefGoogle Scholar
- 15.J. S. Gavaler and D. H. Van Thiel (1987) Reproductive consequences of alcohol abuse: males and females compared and contrasted.Mutation Res.186, 269–277.PubMedCrossRefGoogle Scholar
- 16.R. R. Schade, G. Bonner, V. C. Gay, and D. H. Van Thiel (1983) Evidence for a direct inhibitory effect of ethanol upon gonadotropin secretion at the pituitary level.Alcohol. Clin. Exp. Res.7, 150–152.PubMedCrossRefGoogle Scholar
- 17.W. L. Dees and G. P. Kozlowski (1984) Quantitative and qualitative effects of ethanol on the LHRH-LH axis of the rat.Peptides5(Suppl. 1), 209–213.PubMedCrossRefGoogle Scholar
- 18.EM. Ching, M. Valenca, and A. Negro-Vilar (1988) Acute ethanol treatment lowers hypophyseal portal plasma luteinizing hormone-releasing hormone (LH-RH) and systemic plasma LH levels in orchidectomized rats.Brain Res.443, 325–328.PubMedCrossRefGoogle Scholar
- 19.K. W. Chung (1987) Effects of alcohol feeding on androgen receptors in the rat pituitary gland.Life Sci.41, 2077–2082.PubMedCrossRefGoogle Scholar
- 20.C. R. Pohl, R. A. Guilinger, and D. H. Van Thiel (1987) Inhibitory action of ethanol on luteinizing hormone secretion by rat anterior pituitary cells in culture.Endocrinology120, 849–852.PubMedCrossRefGoogle Scholar
- 21.L. Somer, K.-H. Wrobel, and M. Schimmel (1988) Castration cells in rat adenohypophysis after long-term alcohol consumption.Acta Anat.131, 41–46.PubMedCrossRefGoogle Scholar
- 22.K. W. Chung (1989) Effect of ethanol on androgen receptors in the anterior pituitary, hypothalamus and brain cortex in rats.Life Sci.44, 273–280.PubMedCrossRefGoogle Scholar
- 23.M. A. Emanuele, J. J. Tentler, M. M. Halloran, N. V. Emanuele, L. Wallock, and M. R. Kelley (1992) The effect of acute in vivo ethanol exposure on follicle-stimulating hormone transcription and translation.Alcohol. Clin. Exp. Res.16, 776–780.PubMedCrossRefGoogle Scholar
- 24.I Salonen, P. Pakarinen, and I. Huhtaniemi (1992) Effect of chronic ethanol diet on expression of gonadotropin genes in the male rat.J. Pharmacol. Exp. Ther.260, 463–467.PubMedGoogle Scholar
- 25.J. Ellingboe and C. C. Varanelli (1979) Ethanol inhibits testosterone biosynthesis by direct action on Leydig cells.Res. Commun. Chem. Pathol. Pharmacol.24, 87–102.PubMedGoogle Scholar
- 26.R. A. Anderson, B. R. Willis, C. Oswald, J. M. Reddy, S. A. Beyler, and L. J. D. Zaneveld (1980) Hormonal imbalance and alterations in testicular morphology induced by chronic ingestion of ethanol.Biochem. Pharmacol.29, 1409–1419.PubMedCrossRefGoogle Scholar
- 27.C. F. Cobb, J. S. Gavaler, and D. H. Van Thiel (1981) Is ethanol a testicular toxin?Clin. Toxicol.18, 149–154.PubMedCrossRefGoogle Scholar
- 28.V. Bhalla, V. Rajan, and M. Neuman (1983) Alcohol-induced luteinizing hormone receptor deficiency at the testicular level.Alcohol. Clin. Exp. Res.7, 153–162.PubMedCrossRefGoogle Scholar
- 29.T. V. Widenius, M. M. Orava, R. K. Vihko, R. H. Ylikahri, and C. J. P. Eriksson (1987) Inhibition of testosterone biosynthesis by ethanol: multiple sites and mechanisms in dispersed Leydig cells.J. Steroid Biochem.28, 185–188.PubMedCrossRefGoogle Scholar
- 30.A. K. Orpana, M. M. Orava, R. K. Vihko, M. Harkonen, and C. J. P. Eriksson (1990) Ethanol-induced inhibition of testosterone biosynthesis in rat Leydig cells: central role of mitochondrial NADH redox state.J. Steroid Biochem.36, 603–608.PubMedCrossRefGoogle Scholar
- 31.M. L. Adams and T. J. Cicero (1991) Effects of alcohol on 0-endorphin and reproductive hormones in the male rat.Alcohol. Clin. Exp. Res.15, 685–692.PubMedCrossRefGoogle Scholar
- 32.R. A. Anderson, J. F. Phillips, S. H. Berryman, and L. J. D. Zaneveld (1989) Testosterone production by the prepubertal mouse testis is not depressed by ethanol.Reprod. Toxicol.3, 91–100.PubMedCrossRefGoogle Scholar
- 33.R. A. Anderson, J. F. Phillips, S. H. Berryman, and L. J. D. Zaneveld (1989) Ethanol-induced delayed male puberty in mice is not due to impaired Leydig cell function.Reprod. Toxicol.3, 101–113.PubMedCrossRefGoogle Scholar
- ;R. A. Anderson, J. F. Phillips, and L. J. D. Zaneveld (1989) Chronic ethanol ingestion during puberty alters the transient increase in testicular 5a-reductase in the Swiss-Webster mouse.J. Androl.10, 28–36.PubMedGoogle Scholar
- 35.A. I. Esquifino, A. Mattes, C. Agrasal, I. Martin, J. M. Canovas, and J. Fermoso (1989) Time-dependent effects of alcohol on the hypothalamic—hypophyseal—testicular function in the rat.Alcohol. Clin. Exp. Res.13, 219–223.PubMedCrossRefGoogle Scholar
- 36.T. J. Cicero, D. Bernstein, and T. M. Badger (1978) Effects of acute alcohol administration on reproductive endocrinology in the male rat.Alcohol. Clin. Exp. Res.2, 249–254.PubMedCrossRefGoogle Scholar
- 37.D. H. Van Thiel, J. S. Gavaler, C. F. Cobb, R. J. Sherins, and R. Lester (1979) Alcohol-induced testicular atrophy in the adult male rat.Endocrinology105, 888–895.PubMedCrossRefGoogle Scholar
- 38.R. E. Chapin, G. R. Breese, and R. A. Mueller (1980) Possible mechanisms of reduction of plasma luteinizing hormone by ethanol.J. Pharmacol. Exp. Ther.212, 6–10.PubMedGoogle Scholar
- 39.A. Mateos, J. Fermoso, C. Agrasal, I. Martin, J. Paz-Bouza, J. A. F. Tresguerres, and A. I. Esquifino (1987) Efecto del consumo cronico de alcohol sobre el eje hipothalamo-hipofiso-testicular en la rata A.Revista Espan. Fisiolog.43, 33–38.Google Scholar
- 40.M. Valimaki, J. A. Tuominen, I. Huhtaniemi, and R. Ylkahri (1990) The pulsatile secretion of gonadotropins and growth hormone, and the biological activity of luteinizing hormone in men acutely intoxicated with ethanol.Alcohol. Clin. Exp. Res.14, 928–931.PubMedCrossRefGoogle Scholar
- 41.C. Rivier, S. Rivest, and W. Vale (1992) Alcohol-induced inhibition of LH secretion in intact and gonadectomized male and female rats: possible mechanisms.Alcohol. Clin. Exp. Res.16, 935–941.PubMedCrossRefGoogle Scholar
- 42.D. H. Van Thiel and J. S. Gavaler (1982) The adverse effects of ethanol upon hypothalamic-pituitary-gonadal function in males and females compared and contrasted.Alcohol. Clin. Exp. Res.6, 179–185.PubMedCrossRefGoogle Scholar
- 43.D. H. Van Thiel (1983) Ethanol: its adverse effects upon the hypothalamic-pituitary-gonadal axis.J. Lab. Clin. Med.101, 21–33.PubMedGoogle Scholar
- 44.N. K. Mello, J. H. Mendelson, M. P. Bree, J. Ellingboe, and A. S. T. Skupny (1985) Alcohol effects on luteinizing hormone and testosterone in male macaque monkeys.J. Pharmacol. Exp. Ther.233, 588–596.PubMedGoogle Scholar
- 45.E. T. H. Tan, R. H. Johnson, D. G. Lambie, M. E. Vijayasenan, and E. A. Whiteside (1984) Erectile impotence in chronic alcoholics.Alcohol. Clin. Exp. Res.8, 297–301.PubMedCrossRefGoogle Scholar
- 46.A. Iranmanesh, J. D. Veldhuis, E. Samojlik, A. D. Rogol, M. L. Johnson, and G. Lizarralde (1988) Alterations in the pulsatile properties of gonadotropin secretion in alcoholic men.J. Androl.9, 207–214.PubMedGoogle Scholar
- 47.G. P. Redmond (1980) Effect of ethanol on endogenous rhythms of growth hormone secretion.Alcohol. Clin. Exp. Res.4, 50–56.PubMedCrossRefGoogle Scholar
- 48.M. Emanuele, M. Kelley, J. Tentler, N. Emanuele, and A. Lawrence (1990) The effect of ETOH on pituitary hormone gene transcription and translation.Alcohol. Clin. Exp. Res.14, 285.Google Scholar
- 49.M. Kelley, J. Tentler, M. Halloran, L. Kirsteins, N. Emanuele, A. Lawrence, and M. A. Emanuele (1991) Effect of ETOH on the growth hormone releasing factor (GHF)-growth hormone (GH) axis in the male rat.Alcohol. Clin. Exp. Res.15, 326.Google Scholar
- 50.D. H. Van Thiel, J. S. Gavaler, R. Lester, and M. D. Goodman (1975) Alcohol-induced testicular atrophy: an experimental model for hypogonadism occurring in chronic alcoholic men. Gastroenterology 69, 326–332.PubMedGoogle Scholar
- 51.R. A. Anderson, K. A. Feathergill, and K. Schwartzbauer (1989) Chronic ethanol treatment of male mice prevents the puberty-associated increase in FSH.Biol. Reprod.40 (Suppl. 1), 153.Google Scholar
- 52.J. K. Hiney and W. L. Dees (1991) Ethanol inhibits luteinizing hormone-releasing hormone release from the median eminence of prepubertal female rats in vitro: investigation of its actions on norepinephrine and prostaglandin-E2.Endocrinology128, 1404–1408.PubMedCrossRefGoogle Scholar
- 53.R. A. Anderson and K. A. Feathergill (1990) Differential gonadotropin response to chronic ethanol treatment of pubertal mice.J. Androl.11, P29.Google Scholar
- 54.J. Nazian and V. B. Mahesh (1980) Hypothalamic, pituitary, testicular, and secondary organ functions and interactions during the sexual maturation of the male rat.Arch. Androl.4, 283–303.PubMedCrossRefGoogle Scholar
- 55.G. Grizard, A. Azzaoui, and D. Boucher (1987) Testosterone, androstenedione, progesterone and 17 alpha-hydroxyprogesterone in plasma and testes of immature rats under basal conditions and after HCG stimulation. Effect of bilateral cryptorchidism.J.Steroid Biochem. 28, 703–710.CrossRefGoogle Scholar
- 56.C. Chubb and L. L. Ewing (1981) Steroid secretion by sexually immature rat and rabbit testes perfused in vitro.Endocrinology109, 1999–2003.PubMedCrossRefGoogle Scholar
- 57.C. Jean-Faucher, M. Berger, M. de Turckheim, G. Veyssiere, and C. Jean (1985) Testosterone and dihydrotestosterone levels in the epididymis, vas deferens and preputial gland of mice during sexual maturation.Int. J. Androl.8, 44–57.PubMedCrossRefGoogle Scholar
- 58.M. Tsuji, M. Takeyama, D. Takatsuka, H. Yabumoto, N. Terada, and K. Matsumoto (1984) 5 alpha-and 5 beta-reductases for 4-ene-3-ketosteroids and 17 beta-ol-dehydrogenase in epididymis and testis of golden hamster during sexual development.J. Steroid Biochem.21, 179–183.PubMedCrossRefGoogle Scholar
- 59.L. Cuttler, R. L. Rosenfield, D. A. Ehrmann, M. Kreiter, S. Burstein, J. F. Cara, and L. L. Levitsky (1993) Maturation of gonadotropin and sex steroid responses to gonadotropin-releasing hormone agonist in males.J. Clin.Endocrinol. Metab. 76, 362–366.PubMedCrossRefGoogle Scholar
- 60.H. G. M. Raj and M. Dym (1976) The effects of selective withdrawal of FSH or LH on spermatogenesis in the immature rat.Biol. Reprod.14, 489–494.Google Scholar
- 61.T. D. Nandedkar, B. S. Sarvamangala, V. P. Raghavan, and A. R. Sheth (1982) Effect of FSH deprivation on spermatogenesis in prepubertal mice.Arch. Androl.8, 257–260.PubMedCrossRefGoogle Scholar
- 62.S. J. Nazian and V. B. Mahesh (1979) Sexual maturation of the male rat: influence of androgens on the pituitary response to single or multiple injections of LH-RH.Neuroendocrinology29, 313–322.PubMedCrossRefGoogle Scholar
- 63.S. J. Nazian (1985) Induction of the self-priming effect of luteinizing hormone releasing hormone during the sexual maturation of the male rat (42107).Proc. Soc. Exp. Biol. Med.179, 348–351.PubMedGoogle Scholar
- 64.J. M. S. Bartlett, H. M. Charlton, I. C. A. F. Robinson, and E. Nieschlag (1990) Pubertal development and testicular function in the male growth hormone-deficient rat.J. Endocrinol.126, 193–201.PubMedCrossRefGoogle Scholar
- 65.J. M. B. Wennink, H. A. Delemarre-van de Waal, R. Schoemaker, G. Blaauw, C. van den Braken, and J. Schoemaker (1990) Growth hormone secretion patterns in relation to LH and testosterone secretion throughout normal male puberty.Acta Endocrinol.123, 263–270.PubMedGoogle Scholar
- 66.J. P. Bourguignon (1991) Growth and timing of puberty: reciprocal effects.Hormone Res.36, 131–135.PubMedCrossRefGoogle Scholar
- 67.H. A. Delemarre-van de Waal, J. M. B. Wennink, and R. J. H. Odink (1991) Gonadotrophin and growth hormone secretion throughout puberty.Acta Paediatr. Scand.(Suppl.)372, 26–31.Google Scholar
- 68.A. Steinberger (1979) Inhibin production by Sertoli cells in culture.J. Reprod. Fertil.26(Suppl.), 31–45.Google Scholar
- 69.J. M. Saez, M. H. Perrard-Sapori, P. G. Chatelain, E. Tabone, and M. A. Rivarola (1987) Paracrine regulation of testicular function.J. SteroidBiochem. 27, 317–329.Google Scholar
- 70.R. B. Oonk and J. A. Grootegoed (1988) Insulin-like growth factor I (IGF-I) receptors on Sertoli cells from immature rats and age-dependent testicular binding of IGF-I and insulin.Mol. Cell Endocrinol.55, 33–43.PubMedCrossRefGoogle Scholar
- 71..K. S. Iyer and S. M. McCann (1987) Delta sleep inducing peptide (DSIP) stimulates the release of LH but not FSH via a hypothalamic site of action in the rat.Brain Res. Bull.19, 535–538.PubMedCrossRefGoogle Scholar
- 72.R. W. Rivest, M. E. E. Jaconi, N. Gruaz, P. C. Sizonenko, and M. L. Aubert (1987) Short-term and long-term effects of melatonin on GnRH-stimulated gonadotropin secretion in pituitaries of sexually maturing rats.Neuroendocrinology46, 379–386.PubMedCrossRefGoogle Scholar
- 73.E. Kulin, L. M. Demers, A. D. Rogol, and J. D. Veldhuis (1987) The effect of long-term opiate antagonist administration to pubertal boys.J. Androl.8, 374–377.PubMedGoogle Scholar
- 74.M. L. Dufau (1988) Endocrine regulation and communicating functions of the Leydig cell. Ann.Rev. Physiol.50, 483–508.CrossRefGoogle Scholar
- 75.A. Fabbri, G. Knox, E. Buczko, and M. L. Dufau (1988) Beta-endorphin production by the fetal Leydig cell: regulation and implications for paracrine control of Sertoli cell function.Endocrinology122, 749–755.PubMedCrossRefGoogle Scholar
- 76.S. D. Michael, S. B. Kaplan, and B. T. Macmillan (1980) Peripheral plasma concentrations of LH, FSH, prolactin and GH from birth to puberty in male and female mice. J. Reprod. Fert. 59, 217–222.CrossRefGoogle Scholar
- 77.J. Marson, S. Meuris, R. W. Cooper, and P. Jouannet (1991) Puberty in the male chimpanzee: time-related variations in luteinizing hormone, follicle-stimulating hormone, and testosterone.Biol. Rep rod.44, 456–460.CrossRefGoogle Scholar
- 78.K. E. Oerter, M. M. Uriarte, S. R. Rose, K. M. Barnes, and G. B. Cutler (1990) Gonadotropin secretory dynamics during puberty in normal girls and boys.J. Clin. Endocrino!. Metab.71, 1251–1258.CrossRefGoogle Scholar
- 79.J. F. Phillips, R. A. Anderson, and S. Berryman (1988) Altered Leydig cell function in mice exposed to chronic ethanol treatment during puberty.Biol. Reprod.38(Suppl. 1), 157.Google Scholar
- 80.J. M. Saez, O. Avallet, H. Lejeune, and P. G. Chatelain (1991) Cell—cell communication in the testis.Hormone Res.36, 104–115.PubMedCrossRefGoogle Scholar
- 81.M. Parvinen, A. F. Byskov, C. Y. Andersen, and J. Grinsted (1982) Is the spermatogenic cycle regulated by MIS and MPS?Ann. NY Acad. Sci.383, 483–484.CrossRefGoogle Scholar
- 82.W.W. Bardin, C. Shaha, J. Mather, Y. Jacomon, and D. T. Brieger (1984) Identification and possible function of pro-opiomelanocortin-derived peptides in the testis.Ann. NY Acad. Sci.438, 346–364.PubMedCrossRefGoogle Scholar
- 83.J. B. Yee and J. C. Hutson (1985) Effects of testicular macrophage-conditioned medium on Leydig cells in culture.Endocrinology116, 2682–2684.PubMedCrossRefGoogle Scholar
- 84.M. K. Skinner, K. Takacs, and R. J. Coffey (1989) Transforming growth factor-alpha gene expression and action in the seminiferous tubule: peritubular cell-Sertoli cell interactions.Endocrinology124, 845–854.PubMedCrossRefGoogle Scholar
- 85.M. G. Hunter, M. H. F. Sullivan, C. J. Dix, L. F. Aldred, and B. A. Cooke (1982) Stimulation and inhibition by LIIRH analogues of cultured rat Leydig cell function and lack of effect on mouse Leydig cells.Mol. Cell Endocrino!.27, 31–44.CrossRefGoogle Scholar
- 86.R. M. Sharpe and H. M. Fraser (1983) The role of LH in regulation of Leydig cell responsiveness to an LHRH agonist.Mol. Cell Endocrino!.33, 131–146.CrossRefGoogle Scholar
- 87.M. K. Skinner, P. M. Fetterolf, and C. T. Anthony (1988) Purification of a paracrine factor, P-Mod-S, produced by testicular peritubular cells that modulates Sertoli cell function.J. Biol. Chem.263, 2884–2890.PubMedGoogle Scholar
- 88.E. Y. Adashi, C. E. Resnick, and B. R. Zirkin (1987) Antigonadal activity of the neurohypophyseal hormones: in vivo regulation of testicular function of hypophysectomized rats.Biol. Reprod.37, 935–946.PubMedCrossRefGoogle Scholar
- 89.K. N. Pandey and M.-C. Orgebin-Crist (1991) Atrial natriuretic factor in mammalian testis: immunological detection in spermatozoa.Biochern. Biophys. Res. Commun.180, 437–444.CrossRefGoogle Scholar
- 90.A. Janecki and A. Steinberger (1987) Vectorial secretion of transferrin and androgen binding protein in Sertoli cell cultures: effect of extracellular matrix, peritubular myoid cells and medium composition.Mol. Cell Endocrino!.52, 125–135.CrossRefGoogle Scholar
- 91.M. K. Skinner, K. Takacs, and R. J. Coffey (1989) Transforming growth factor-alpha gene expression and action in the seminiferous tubule: peritubular cell-Sertoli cell interactions.Endocrinology124, 845–854.PubMedCrossRefGoogle Scholar
- 92.J A. Hettle, E. Balekjian, P. S. Tung, and I. B. Fritz (1988) Rat testicular peritubular cells in culture secrete an inhibitor of plasminogen activator activity.Biol. Reprod.38, 359–371.PubMedCrossRefGoogle Scholar
- 93.G. Verhoeven and J. Cailleau (1988) Testicular peritubular cells secrete a protein under androgen control that inhibits induction of aromatase activity in Sertoli cells.Endocrinology123, 2100–2110.PubMedCrossRefGoogle Scholar
- 94.D. Djakiew and M. Dym (1988) Pachytene spermatocyte proteins influence Sertoli cell function.Biol. Reprod.39, 1193–1205.PubMedCrossRefGoogle Scholar
- 95.B. Le Magueresse and B. Jegou (1988) In vitro effects of germ cells on the secretory activity of Sertoli cells recovered from rats of different ages.Endocrinology122, 1672–1680.PubMedCrossRefGoogle Scholar
- 96.B. Onoda and D. Djakiew (1990) Modulation of Sertoli cell secretory function by rat round spermatid protein(s).Mol. Cell Endocrinol.73, 35–44.PubMedCrossRefGoogle Scholar
- 97.M. H. Perrard-Sapori, P. C. Chatelain, N. Rogemond, and J. M. Saez (1987) Modulation of Leydig cell functions by culture with Sertoli cells or with Sertoli cell-conditioned medium: effect of insulin, somatomedin-C and FSH.Mol. Cell Endocrino!.50, 193–201.CrossRefGoogle Scholar
- 98.V. Papadopoulos, P. Kamtchouing, M. A. Drosdowsky, M. T. Hochereau de Reviers, and S. Carreau (1987) Adult rat Sertoli cells secrete a factor or factors which modulate Leydig cell function.J. Endocrinol.114, 459–467.PubMedCrossRefGoogle Scholar
- 99.A. J. Grootenhuis, R. Nelsen, M. A. Timmerman, J. W. Hoogerbrugge, F. F. G. Rommerts, and F. H. De Jong (1990) Short-term stimulatory effect of Sertoli cell conditioned medium on Leydig cell steroidogenesis is not mediated by inhibin.J. Steroid Biochem.36, 445–449.PubMedCrossRefGoogle Scholar
- 100.G. Verhoeven and J. Cailleau (1990) Influence of coculture with Sertoli cells on steroidogenesis in immature rat Leydig cells.Mol. Cell Endocrino!.71, 239–251.CrossRefGoogle Scholar
- 101.A. R. Glass, D. C. Herbert, and J. Anderson (1986) Fertility onset, spermatogenesis, and pubertal development in male rats: effect of graded underfeeding.Pediatr. Res.20, 1161–1167.PubMedCrossRefGoogle Scholar
- 102.Ghosh, A. Bartke, P. Grasso, L. E. Reichert, and L. D. Russell (1992) Structural manifestations of the rat Sertoli cell to hypophysectomy: a correlative morpho-metric and endocrine study.Endocrinology131, 485–497.PubMedCrossRefGoogle Scholar
- 103.R, mi.,. D. Russell, T. J. Corbin, H. P. Ren, A. Amador, A. Bartke, and S. Ghosh (1992) Structural changes in rat Leydig cells posthypophysectomy: a morphometric and endocrine study.Endocrinology131, 498–508.PubMedCrossRefGoogle Scholar
- 104.D. Hamilton and F. H. Bronson (1986) Food restriction and reproductive development: male and female mice and male rats. Am.J. Physiol.250, R370–R376.Google Scholar
- 105.J. L. Blank and C. Desjardins (1985) Differential effects of food restriction on pituitary-testicular function in mice.Am. J. Physiol.248, R181–R189.Google Scholar
- 106.ML. D. Russell, J. P. Malone, and S. L. Karpas (1981) Morphological pattern elicited by agents affecting spermatogenesis by disruption of its hormonal stimulation.Tissue Cell13, 369–380.PubMedCrossRefGoogle Scholar
- 107.R. E. Chapin, K. T. Morgan, and J. S. Bus (1983) The morphogenesis of testicular degeneration induced in rats by orally administered 2,5-hexanedione.Exp. Mol. Pathol.38, 149–169.PubMedCrossRefGoogle Scholar
- 108.AA. Tsatsoulis, E. Whitehead, J. St. John, S. M. Shalet, and W. R. Robertson (1987) The pituitary-Leydig cell axis in men with severe damage to the germinal epithelium. Clin. Endocrinol. 27, 683–689.Google Scholar
- 109.G. P. Risbridger, J. B. Kerr, and K. Rich (1981) Temporal changes in rat Leydig cell function after the induction of bilateral cryptorchidism.J. Reprod. Fertil.63, 415–423.PubMedCrossRefGoogle Scholar
- 110.D. M. de Kretser, R. M. Sharpe, and I. A. Swanston (1979) Alterations in steroidogenesis and human chorionic gonadotropin binding in the cryptorchid rat testis.Endocrinology105, 135–138.PubMedCrossRefGoogle Scholar
- 111.B. D. Schanbacher (1980) Androgen secretion and characteristics of testicular HCG binding in cryptorchid rats.J. Reprod. Fert.59, 145–150.CrossRefGoogle Scholar
- 112.C. W. Bardin, C. Y. Cheng, N. A. Musto, and G. L. Gunsalus (1988) The Sertoli cell, inThe Physiology of Reproduction.E. Knobil, J. D. Neill, L. L. Ewing, G. S. Greenwald, C. L. Marken, and D. W. Pfaff, eds. Raven, New York, pp. 933–974.Google Scholar
- 113.B. P. Setchell and D. E. Brooks (1988) Anatomy, vasculature, innervation, and fluids of the male reproductive tract, inThe Physiology of Reproduction. E. Knobil, J. D. Neill, L. L. Ewing, G. S. Greenwald, C. L. Marken, and D. W. Pfaff, eds. Raven, New York, pp. 753–836.Google Scholar
- 114.L. D. Russell and R. N. Peterson (1985) Sertoli cell junctions: morphological and functional correlates.Int. Rev. Cytol.94, 177–211.PubMedCrossRefGoogle Scholar
- 115.J. P. Mather, G. L. Gunsalus, N. A. Musto, C. Y. Cheng, M. Parvinen, W. Wright, V. Perez-Infante, A. Margioris, A. Liotta, R. Becker, D. T. Krieger, and C. W. Bardin (1983) The hormonal and cellular control of Sertoli cell secretion.J. Steroid Biochem.19, 41–51.PubMedCrossRefGoogle Scholar
- 116.D. K. Agarwal, W. H. Lawrence, and J. Autian (1985) Antifertility and mutagenic effects in mice from parenteral administration of Di-2-ethylhexylphthalate (DEHP).J. Toxicol. Environ. Health16, 71–84.PubMedCrossRefGoogle Scholar
- 117.R. M. Pelletier and S. W. Byers (1992) The blood-testis barrier and Sertoli cell junctions: structural considerations.Microscop. Res. Tech.20, 3–33.CrossRefGoogle Scholar
- 118.N. B. Gilula, D. W. Fawcett, and A. Aoki (1976) The Sertoli cell occluding junctions and gap junctions in mature and developing mammalian testis.Develop. Biol.50, 142–168.PubMedCrossRefGoogle Scholar
- 119.. L. D. Russell, A. Bartke, and J. C. Goh (1989) Postnatal development of the Sertoli cell barrier, tubular lumen, and cytoskeleton of Sertoli and myoid cells in the rat, and their relationship to tubular fluid secretion and flow.Am. J. Anat.184, 179–189.PubMedCrossRefGoogle Scholar
- 120.B. P. Setchell, M. S. Laurie, and L. G. Jarvis (1981) The blood-testis barrier at puberty, inDevelopment and Function of Reproductive Organs.A. G. Byskov and H. Peters, eds. Excerpta Medica, Amsterdam, pp. 186–190.Google Scholar
- 112.J. Nazian (1986) Concentrations of free testosterone, total testosterone, and androgen binding protein in the peripheral serum of male rats during sexual maturation.J. Androl.7, 49–54.PubMedGoogle Scholar
- 122.N. Kuhn-Velten, D. Bos, R. Schermer, and W. Staib (1987) Age-dependence of the rat Leydig cell and Sertoli cell function: development of the peripheral testosterone level and its relation to mitochondrial and microsomal cytochromes P-450 and to androgen-binding protein.Acta Endocrinol. (Copenhagen)115, 275–281.Google Scholar
- 123.C. J. Flickinger (1967) The postnatal development of the Sertoli cells of the mouse. Z.für Zellforschung.78, 92–113.CrossRefGoogle Scholar
- 124.B. Tabakoff, M. Bulat, and R. A. Anderson (1975) Ethanol inhibition of transport of 5-hydroxyindoleacetic acid from cerebrospinal fluid.Nature254, 708–710.PubMedCrossRefGoogle Scholar
- 125.A. Gulati, C. Nath, K. Shanker, R. C. Srimal, K. N. Dhawan, and K. P. Bhargava (1985) Effect of alcohols on the permeability of blood—brain barrier.Pharmacol. Res. Commun.17, 85–93.PubMedCrossRefGoogle Scholar
- 126.P. A. Stewart, E. M. Hayakawa, and P. L. Carlen (1988) Ethanol and pentobarbital in combination increase blood—brain barrier permeability to horseradish peroxidase.Brain Res.443, 12–20.PubMedCrossRefGoogle Scholar
- 127.R. A. Anderson, J. M. Frasor, C. Cook, and L. D. Russell (1992) Chronic ethanol (EtOH) treatment during puberty reduces secretory activity of Sertoli (S) cells and impairs their ability to form tight junctions in primary culture. 48th Annual Meeting of the American Fertility Society, New Orleans, LA, Progr. Suppl. S190,S191.Google Scholar
- 128.H. Farghali, D. S. Williams, J. Gavaler, and D. H. Van Thiel (1991) Effect of short-term ethanol feeding on rat testes as assessed by “P NMR spectroscopy, ‘H NMR imaging and biochemical methods.Alcohol. Clin. Exp. Res.15, 1018–1023.PubMedCrossRefGoogle Scholar
- 129.D. M. Blackburn, A. J. Gray, S. C. Lloyd, C. M. Sheard, and P. M. D. 130; Foster (1988) A comparison of the effects of three isomers of dinitrobenzene on the testis in the rat.Toxicol. Appl. Pharmacol.92, 54–64.PubMedCrossRefGoogle Scholar
- 130.D. M. Creasy, J. R. Foster, and P. M. D. Foster (1983) The morphological development of di-N-pentyl phthalate induced testicular atrophy in the rat.J. Pathol.139, 309–321.PubMedCrossRefGoogle Scholar
- 131..Boekelheide (1988) Rat testis during 2,5-hexanedione intoxication and recovery. II. Dynamics of pyrrole reactivity, tubulin content, and microtubule assembly.Toxicol. Appl. Pharmacol.92, 28–33.PubMedCrossRefGoogle Scholar
- 132.J. B. Gray and J. A. Beamand (1984) Effect of some phthalate esters and other testicular toxins on primary cultures of testicular cells.Food Chem. Toxicol.22, 123–131.PubMedCrossRefGoogle Scholar
- 133.K. Boekelheide (1993) Sertoli cell toxicants, inThe Sertoli Cell. L. D. Russell and M. D. Griswold, eds. Cache River, Clearwater, FL, pp. 551–575.Google Scholar
- 134.J. Chakraborty (1993) Conditions adversely affecting Sertoli cells, inThe Sertoli Cell.L. D. Russell and M. D. Griswold, ed. Cache River, Clearwater, FL, pp. 578–610.Google Scholar
- 135.A. Bellve and W. Zheng (1989) Growth factors as autocrine and paracrine modulators of male gonadal functions.J. Reprod. Fert.85, 771–793.CrossRefGoogle Scholar
- 136.A. Bergh, A. A. Bergh, J. E. Damber, M. Hammar, and G. Selstam (1984) Steroid biosynthesis and Leydig cell morphology in unilaterally cryptorchid rats.Acta Endocrinol.107, 556–562.PubMedGoogle Scholar
- 137.A. Dostal, R. E. Chapin, S. A. Stefanski, M. W. Harris, and B. A. Schwetz(1988) Testicular toxicity and reduced Sertoli cell numbers in neonatal rats by di(2-ethylhexyl)phthalate and the recovery of fertility as adults.Toxicol. Appl. Pharmacol.95, 104–121.PubMedCrossRefGoogle Scholar
- 138.B Sjoberg, U. Bondesson, L. Kjellen, N.-G. Lindquist, G. Montin, and L. Ploen (1985) Kinetics of Di-(2-ethylhexyl) phthalate in immature and mature rats and effect on testis. Acta Pharmacol. Toxicol. 56, 30–37.Google Scholar
- 139.L. D. Russell, M. Talbon-Doran, J. E. Weber, V. Wong, and R. N. Peterson (1983) Three-dimensional reconstruction of a rat stage V Sertoli cell: III. A study of specific cellular relationships. Am.J. Anat.167, 181–192.PubMedCrossRefGoogle Scholar
- 140.L. Byers, M. Hadley, D. Djakiew, and M. Dym (1986) Growth and characterization of polarized monolayers of epididymal epithelial cells and Sertoli cells in dual environment culture chambers.J. Androl.7, 59–68.PubMedGoogle Scholar
- 141.A. Janecki and A. Steinberger (1986) Polarized Sertoli cell functions in a new two-compartment culture system.J. Androl. 769–71.PubMedGoogle Scholar
- 142.J. Weinberg and A. W. Vogl (1988) Effects of ethanol consumption on the morphology of the rat seminferous epithelium.J. Androl.9, 261–269.PubMedGoogle Scholar
- 143.J. M. Frasor, R. A. Anderson, and L. D. Russell (1992) Ethanol impairs secretory activity of Sertoli cells in conventional and bicameral culture.Biol. Reprod.46(Suppl. 1), 171.Google Scholar
- 144.F. Diamond, L. Ringenberg, D. Macdonald, J. Barnes, C. S. Hu, G. Duckett, M. Sweetland, and A. Root (1986) Effects of drug and alcohol abuse upon pituitary-testicular function in adolescent males.J. Adolesc. Health Care 728–33.PubMedCrossRefGoogle Scholar