Negative Pressure Wound Therapy in the Management of Pressure Ulcers

  • Valentina Dini
  • Salvatore Panduri
  • Marco Romanelli


The mechanisms of action of negative pressure wound therapy (NPWT) has shown specific effects including removal of excess fluid and improving wound bed circulation, reducing bacterial load, promoting cell proliferation and synthesis, increasing the level of angiogenic and stimulatory cytokines, and endothelial cell mobilization. These effects, as predicated by the adequate delivery of negative pressure to the wound site, are translated into clinical outcomes such as improved tissue perfusion, reduced tissue edema, and increased granulation tissue formation. The scientific foundation for NPWT forms the basis for the improved patient outcomes observed in the published clinical literature and supports its use for temporizing wounds and protecting them from external contamination during long-term care.


Negative pressure wound therapy Tissue perfusion Fluid removal 


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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2018

Authors and Affiliations

  • Valentina Dini
    • 1
  • Salvatore Panduri
    • 1
  • Marco Romanelli
    • 1
  1. 1.Department of DermatologySanta Chiara Hospital, University of PisaPisaItaly

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