Neutrophilic Dermatoses

Chapter

Abstract

Neutrophilic dermatoses are a group of skin conditions that involve dermal inflammation by neutrophils without an identified infectious agent. The neutrophilic dermatoses featured in this chapter are Sweet’s syndrome, bowel-associated dermatosis/arthritis syndrome, pyoderma gangrenosum, juvenile idiopathic arthritis/Still’s disease, erythema marginatum, neutrophilic eccrine hidradinitis, and rheumatoid neutrophilic dermatosis. Many of these conditions have systemic associations as well as drug-induced forms. Sweet’s syndrome is the prototypical neutrophilic dermatosis and is most widely associated with a recent upper respiratory tract infection, although an almost identical eruption is associated with the use of granulocyte-colony stimulating factor. Bowel-associated dermatosis-arthritis syndrome is associated with bowel bypass surgery and inflammatory bowel disease. Pyoderma gangrenosum is associated with inflammatory bowel disease, but has also been observed after treatment with propylthiouracil and granulocyte-colony stimulating factor. Still’s disease involves fevers, arthritis and arthralgia, and a transient evanescent rash. Erythema elevatum diutinum is a chronic fibrosing form of cutaneous leukocytoclastic vasculitis. Cases of generalized pustular psoriasis have been observed after treatment with salicylates, iodides, and biologic tumor necrosis factor inhibitors. Neutrophrophilic-associated syndromes in patients with rheumatoid arthritis have been associated with use of certain medications, particularly in the case of palisaded neutrophilic granulomatous dermatitis.

Keywords

Neutrophilic dermatoses Sweet’s syndrome Pyoderma gangrenosum Still’s disease Neutrophilic eccrine hidradenitis Rheumatoid neutrophilic dermatosis Drug-induced neutrophilic dermatoses 
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Suggested Reading

  1. Baker H, Ryan TJ. Generalized pustular psoriasis. Br J Dermatol. 1968;80(12):771–93.CrossRefPubMedGoogle Scholar
  2. Brunasso AM, Laimer M, Massone C. Paradoxical reactions to targeted biological treatments: a way to treat and trigger. Acta Derm Venereol. 2010;90(2):183–5.CrossRefPubMedGoogle Scholar
  3. Chandrasekaran SS, Rai R, Vedachalam S, Dorairaj L, Palaniraman S. Erythema elevatum diutinum in association with dermatitis herpetiformis. Indian Dermatol Online J. 2011;5(1):48.CrossRefGoogle Scholar
  4. Cohen PR. Sweet’s syndrome–a comprehensive review of an acute febrile neutrophilic dermatosis. Orphanet J Rare Dis. 2007;2(34):26.Google Scholar
  5. Cohen PR, Kurzrock R. Sweet’s syndrome revisited: a review of disease concepts. Int J Dermatol. 2003;42(10):761–78.CrossRefPubMedGoogle Scholar
  6. De Oliveira ST, Maragno L, Arnone M, Fonseca Takahashi MD, Romiti R. Generalized pustular psoriasis in childhood. Pediatr Dermatol. 2010;27(4):349–54.CrossRefPubMedGoogle Scholar
  7. Grahovac M, Maximiliane Ehmann L, Flaig M, Reibke R, Wollenberg A. Neutrophilic eccrine hidradenitis induced by cytarabine. Acta Dermatovenerol Croat. 2013;20(4):272–283.Google Scholar
  8. Roustan G, Salas C, Cabrera R, Simón A. Neutrophilic eccrine hidradenitis unassociated with chemotherapy in a patient with acute myelogenous leukemia. Int J Dermatol. 2001;40(2):144–7.CrossRefPubMedGoogle Scholar
  9. Sakane T, Takeno M, Suzuki N, Inaba G. Behçet’s disease. N Engl J Med. 1991;341(17):1284–91.CrossRefGoogle Scholar
  10. Schadt CR, Callen JP. Management of neutrophilic dermatoses. Dermatol Ther. 2012;25(2):158–72.CrossRefPubMedGoogle Scholar
  11. Seo JW, Son HH, Choi JH, Lee SK. A case of p-ANCA-positive propylthiouracil-induced pyoderma gangrenosum. Ann Dermatol. 2010;22(1):48–50.PubMedCentralCrossRefPubMedGoogle Scholar
  12. Sharma V, Mahajan VK, Mehta KS, Chauhan PS, Chander B. Erythema elevatum diutinum. Indian J Dermatol Venereol Leprol. 2013;79:238–9.CrossRefPubMedGoogle Scholar
  13. Trickett HB, Cumpston A, Craig M. Azacitidine-associated Sweet’s syndrome. Am J Health Syst Pharm. 2012;69(10):869–71.CrossRefPubMedGoogle Scholar
  14. Truchuelo MT, Alcántara J, Vano‐Galván S, Jaén P, Moreno C. Bowel‐associated dermatosis–arthritis syndrome: another cutaneous manifestation of inflammatory intestinal disease. Int J Dermatol. 2013;52(12):1596–8.CrossRefPubMedGoogle Scholar
  15. Turan H, Kaya E, Gurlevik Z, Erdem H, Oktay M. Neutrophilic eccrine hidradenitis induced by cetuximab. Cutan Ocul Toxicol. 2012;31(2):148–50.CrossRefPubMedGoogle Scholar
  16. Umezawa Y, Ito K, Nakagawa H. Palisaded neutrophilic and granulomatous dermatitis in a rheumatoid arthritis patient after treatment with adalimumab. Eur J Dermatol. 2013;23(6):910–1.Google Scholar
  17. Vandevyvere K, Luyten FP, Verschueren P, Lories R, Segaert S, Westhovens R. Pyoderma gangrenosum developing during therapy with TNF-alpha antagonists in a patient with rheumatoid arthritis. Clin Rheumatol. 2007;26(12):2205–6.CrossRefPubMedGoogle Scholar
  18. Wollina U. Pyoderma gangrenosum–a review. Orphanet J Rare Dis. 2007;2(19):1–8.Google Scholar
  19. Yeh I, George E, Fleckman P. Eccrine hidradenitis sine neutrophils: a toxic response to chemotherapy. J Cutan Pathol. 2011;38(11):905–10.CrossRefPubMedGoogle Scholar
  20. Zobniw CM, Saad SA, Kostoff D, Barthel BG. Bortezomib‐induced Sweet’s syndrome confirmed by rechallenge. Pharmacotherapy. 2014;34(4):e18–21.CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag London 2015

Authors and Affiliations

  1. 1.The Commonwealth Medical CollegeScrantonUSA
  2. 2.Ackerman Academy of DermatopathologyNew YorkUSA

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