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Cartilage Repair, Replacement, and Regenerative Strategies for Osteochondral Lesions of the Talus

  • Samuel B. AdamsEmail author
  • Selene G. Parekh
  • Diego H. Zanolli de Solminihac
  • Evgeny E. Krynetskiy
  • Lew C. Schon
  • Mark E. Easley
Chapter

Abstract

Osteochondral lesions of the talus present a formidable treatment challenge to the orthopaedic surgeon. Historical cartilage repair strategies often result in the formation of fibrocartilage leading to suboptimal clinical results. With advances in regenerative medicine, modern surgical techniques are diverse and employ autograft, allograft, and tissue-engineered constructs for cartilage repair. Fresh and particulated juvenile allograft transplantation have become popular options in the United States. Wordwide, both cellular and acellular tissue-engineered constructs are utilized. In all cases, there is still debate as to the optimal cell source and scaffold material and only short-term clinical results are available. This chapter will review these current as well as experimental techniques for cartilage repair of osteochondral lesions of the talus.

Keywords

Osteochondral lesions of the talus Particulated juvenile allograft transplantation Fresh structural allograft transplantation Tissue-engineered Autologous chondrocyte implantation Matrix-induced autologous chondrocyte implantation Collagen scaffold Bone marrow aspirate concentrate Stem cells 

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Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  • Samuel B. Adams
    • 1
    Email author
  • Selene G. Parekh
    • 2
  • Diego H. Zanolli de Solminihac
    • 3
  • Evgeny E. Krynetskiy
    • 4
  • Lew C. Schon
    • 2
  • Mark E. Easley
    • 5
  1. 1.Department of Orthopaedic SurgeryDuke University Medical CenterDurhamUSA
  2. 2.Department of Orthopaedic SurgeryDuke University Medical Center, North Carolina Orthopaedic ClinicDurhamUSA
  3. 3.Department of Orthopaedic SurgeryClinica AlemanaSantiagoChile
  4. 4.Joint Implant Surgeons of Florida7331 College Parkway, Suite 300Fort MyersUSA
  5. 5.Department of Orthopaedic SurgeryDuke University School of MedicineDurhamUSA

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