Abstract
In order to bring the hitherto discussed material into a broader perspective, it may be helpful to review some of the salient phylogenetic features discussed in Part I. We have seen that in the single-circuit vascular system of the fishes, the gills are placed in series with the systemic circulation (see Fig. 11.11 ). This is a low-pressure, predominantly venous circulation, where the highly effi cient “membrane oxygenator“ system of the gills extracts oxygen, dissolved in water, to satisfy the relatively meager metabolic demands of poikilothermic aquatic species. The two-chambered heart is placed before the gills and generates pressure in the branchial circulation which, unlike in the case of mammals and birds, exceeds the systemic.
Keywords
Critical Illness Functional Capillary Density Sidestream Dark Field Hyperdynamic Circulation Acute Circulatory Failure
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References
- 1.Lenfant C, Johansen K. Gas exchange in gill, skin, and lung breathing. Respir Physiol. 1972;14(1–2):211–8.PubMedCrossRefGoogle Scholar
- 2.Carlson BE, Arciero JC, Secomb TW. Theoretical model of blood flow autoregulation: roles of myogenic, shear-dependent, and metabolic responses. Am J Physiol Heart Circ Physiol. 2008;295(4):H1572–9.PubMedCrossRefGoogle Scholar
- 3.Walley KR. Heterogeneity of oxygen delivery impairs oxygen extraction by peripheral tissues: theory. J Appl Physiol. 1996;81(2):885–94.PubMedGoogle Scholar
- 4.Ellsworth ML, et al. The erythrocyte as a regulator of vascular tone. Am J Physiol Heart Circ Physiol. 1995;269(6):H2155–61.Google Scholar
- 5.Ellsworth ML. Red blood cell-derived ATP as a regulator of skeletal muscle perfusion. Med Sci Sports Exerc. 2004;36(1):35.PubMedCrossRefGoogle Scholar
- 6.Diesen DL, Hess DT, Stamler JS. Hypoxic vasodilation by red blood cells. Circ Res. 2008;103(5):545–53.PubMedCrossRefGoogle Scholar
- 7.Farias III M, et al. Plasma ATP during exercise: possible role in regulation of coronary blood flow. Am J Physiol Heart Circ Physiol. 2005;288(4):H1586–90.PubMedCrossRefGoogle Scholar
- 8.Baek EB, et al. Luminal ATP-induced contraction of rabbit pulmonary arteries and role of purinoceptors in the regulation of pulmonary arterial pressure. Pflügers Arch. 2008;457(2):281–91.PubMedCrossRefGoogle Scholar
- 9.Deem S. Red blood cells and hemoglobin in hypoxic pulmonary vasoconstriction. In: Roach RC, Wagner PD, Hackett PH, editors. Hypoxia and exercise. New York: Springer Science+Business Media; 2006. p. 217–31.CrossRefGoogle Scholar
- 10.Deem S, et al. Red blood cells prevent inhibition of hypoxic pulmonary vasoconstriction by nitrite in isolated, perfused rat lungs. Am J Physiol Heart Circ Physiol. 2007;292(2):H963–70.PubMedCrossRefGoogle Scholar
- 11.Arciero JC, Carlson BE, Secomb TW. Theoretical model of metabolic blood flow regulation: roles of ATP release by red blood cells and conducted responses. Am J Physiol Heart Circ Physiol. 2008;295(4):H1562–71.PubMedCrossRefGoogle Scholar
- 12.Klijn E, et al. The heterogeneity of the microcirculation in critical illness. Clin Chest Med. 2008;29(4):643–54.PubMedCrossRefGoogle Scholar
- 13.Parratt JR. Nitric oxide in sepsis and endotoxaemia. J Antimicrob Chemother. 1998;41 suppl 1:31–9.PubMedCrossRefGoogle Scholar
- 14.Hollenberg SM, Cunnion RE, Zimmerberg J. Nitric oxide synthase inhibition reverses arteriolar hyporesponsiveness to catecholamines in septic rats. Am J Physiol Heart Circ Physiol. 1993;264(2):H660–3.Google Scholar
- 15.Ince C. The microcirculation is the motor of sepsis. Crit Care (Lond). 2005;9:13.CrossRefGoogle Scholar
- 16.Sakr Y, et al. Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock*. Crit Care Med. 2004;32(9):1825.PubMedCrossRefGoogle Scholar
- 17.Fries M, et al. Microcirculation during cardiac arrest and resuscitation. Crit Care Med. 2006;34(12):S454–7.PubMedCrossRefGoogle Scholar
- 18.Fabiano G, et al. Traumatic shock-physiopathologic aspects. G Chir. 2008;29(1–2):51–7.PubMedGoogle Scholar
- 19.Johnson PC. Autoregulation of blood flow. Circ Res. 1986;59(5):483–95.PubMedCrossRefGoogle Scholar
- 20.De Backer D, Ortiz JA, Salgado D. Coupling microcirculation to systemic hemodynamics. Curr Opin Crit Care. 2010;16(3):250.PubMedCrossRefGoogle Scholar
- 21.Hunter J, Doddi M. Sepsis and the heart. Br J Anaesth. 2010;104(1):3–11.PubMedCrossRefGoogle Scholar
- 22.Sprague RS, Stephenson AH, Ellsworth ML. Red not dead: signaling in and from erythrocytes. Trends Endocrinol Metab. 2007;18(9):350–5.PubMedCrossRefGoogle Scholar
- 23.Mitchell G, Skinner JD. An allometric analysis of the giraffe cardiovascular system. Comp Biochem Physiol A Mol Integr Physiol. 2009;154(4):523–9.PubMedCrossRefGoogle Scholar
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