Biochemistry of Zinc in Cell Division and Tissue Growth

  • J. K. Chesters
Chapter
Part of the ILSI Human Nutrition Reviews book series (ILSI HUMAN)

Abstract

Young rats offered a zinc-deficient diet show an abrupt reduction in growth after only a few days on the diet and before a major reduction in total body zinc content or concentration has occurred (Williams and Mills 1970). This coincides with an equally abrupt reduction in food intake to a level which, in pair-fed animals, severely restricts growth (Chesters and Quarterman 1970). However, when the intake of zinc-deficient rats is increased by gavage to that of controls offered the zinc-adequate diet ad lib, the animals fail to grow and become ill (Chesters and Quarterman 1970; Masters et al. 1983). The reduced tissue growth of a zinc-deficient rat results therefore from a zinc-responsive biochemical defect rather than from a physiological effect of loss of appetite.

Keywords

Thymidine Kinase Zinc Deficiency Thymidine Uptake Thymidine Kinase Activity Chick Embryo Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Alvares OF, Meyer J (1973) Thymidine uptake cell migration in cheek epithelium of Cndeficient rats. J Oral Pathol 2: 86–94PubMedCrossRefGoogle Scholar
  2. Anderson EP (1973) Nucleosides and nucleoside kinases. In: Boyer PD (ed) The enzymes, vol 9, 3rd edn. Academic Press, New York, London, pp 69–93Google Scholar
  3. Baker GW, Duncan JR (1983) Possible site of Zn control of hepatoma cell division in Wistar rats. J Natl Cancer Inst 70: 333–336PubMedGoogle Scholar
  4. Barr DH, Harris JW (1973) Growth of P388 leukaemia as an ascites tumor in Zn-deficient mice. Proc Soc Exp Biol Med 144: 284–287PubMedGoogle Scholar
  5. Berg JM (1986) More metal binding fingers. Nature 319: 264–265CrossRefGoogle Scholar
  6. Blanquet S, Plateau P, Brevet A (1983) The role of Zn in 5′,5′ diadenosine tetraphosphate production by aminoacyl-tRNA synthetases. Mol Cell Biochem 52: 3–11PubMedCrossRefGoogle Scholar
  7. Castro CE, Alvares OF, Sevall JS (1986) Zinc deficiency decreases histone Hl° in rat liver. Nutr Reports Int 34: 67–74Google Scholar
  8. Chen S-Y (1986) Autoradiographic study of cell proliferation in acanthotic buccal epithelium of Zn-deficient rabbits. Arch Oral Biol 31: 535–539PubMedCrossRefGoogle Scholar
  9. Chesters JK (1971) Problems caused by variations in food intake in experiments on protein and nucleic acid metabolism. Proc Nutr Soc 30: 1–7PubMedCrossRefGoogle Scholar
  10. Chesters JK (1972) The role of zinc ions in the transformation of lymphocytes by phytohaemagglutinin. Biochem J 130: 133–139PubMedGoogle Scholar
  11. Chesters JK (1975) Comparison of the effects of zinc deprivation and actinomycin D on ribonucleic acid synthesis by stimulated lymphocytes. Biochem J 150: 211–218PubMedGoogle Scholar
  12. Chesters JK (1978) Biochemical functions of zinc in animals. World Rev Nutr Diet 32: 135–164Google Scholar
  13. Chesters JK, Quarterman J (1970) Effects of zinc deficiency on food intake and feeding patterns of rats. Br J Nutr 24: 1061–1069PubMedCrossRefGoogle Scholar
  14. Chesters JK, Will M (1973) Some factors controlling food intake by zinc-deficient rats. Br J Nutr 30: 555–566PubMedCrossRefGoogle Scholar
  15. De Wys W, Pories W (1972) Inhibition of a spectrum of animal tumors by dietary Zn deficiency. J Natl Cancer Inst 48: 375–381Google Scholar
  16. Dinsdale D, Williams RB (1977) The enhancement by dietary Zn deficiency of the susceptibility of the rat to colchicine. Br J Nutr 37: 135–142PubMedCrossRefGoogle Scholar
  17. Dinsdale D, Williams RB (1980) Ultrastructural changes in the sperm tail of Zn-deficient rats. J Comp Pathol 90: 559–566PubMedCrossRefGoogle Scholar
  18. Duncan JR, Hurley LS (1978) Thymidine kinase and DNA polymerase activity in normal and Zn-deficient developing rat embryos. Proc Soc Exp Biol Med 159: 39–43PubMedGoogle Scholar
  19. Eckhert CD, Hurley LS (1977) Reduced DNA synthesis in zinc deficiency: regional differences in embryonic rats. J Nutr 107: 855–861PubMedGoogle Scholar
  20. Falchuk KH, Vallee BL (1985) Zinc and chromatin structure, composition and function. In: Mills CF, Bremner I, Chesters JK (eds) Trace elements in man and animals — TEMA 5. Commonwealth Agricultural Bureaux, Slough, pp 48–55Google Scholar
  21. Falchuk KH, Fawcett DW, Vallee BL (1975) Role of Zn in cell division of E. gracilis. J Cell Sci 17: 57–78PubMedGoogle Scholar
  22. Falchuk KH, Mazus B, Ber E, Ulpino-Lobb L, Vallee BL (1985) Zinc deficiency and the E. gracilis chromatin: formation of an a-amanatin resistant RNA polymerase II. Biochemistry 24: 2576–2580PubMedCrossRefGoogle Scholar
  23. Fell BF, Leigh LC, Williams RB (1973) The cytology of various organs in Zn-deficient rats with particular reference to the frequency of cell division. Res Vet Sci 14: 317–325PubMedGoogle Scholar
  24. Fong LYY, Swak A, Newberne PM (1978) Zinc deficiency and methylbenzyl nitrosamine-induced oesophageal cancer in rats. J Natl Cancer Inst 61: 145–150PubMedGoogle Scholar
  25. Fong LYY, Lee JSK, Chan WC, Newberne PM (1982) Zn deficiency and the induction of oesophageal tumors in rats by benzylmethylamine and sodium nitrite. IARC Sci Publ 41: 679–683PubMedGoogle Scholar
  26. Fuji T (1954) Presence of zinc in nucleoli and its possible role in mitosis. Nature 174: 1108–1109CrossRefGoogle Scholar
  27. Fujioka M, Lieberman I (1964) A Zn2+ requirement for synthesis of deoxyribonucleic acid by rat liver. J Biol Chem 239: 1164–1167PubMedGoogle Scholar
  28. Giugliano R, Millward DJ (1987) The effects of severe Zn deficiency on protein turnover in muscle and thymus. Br J Nutr 57: 139–155PubMedCrossRefGoogle Scholar
  29. Goerlich O, Holler E (1984) Phenylalanyl-tRNA synthetase of E. coli K10. Effects of Zn(II) on partial reactions of diadenosine 5′,5″′-P1, P4 tetraphosphate synthesis, conformation and protein aggregation. Biochemistry 23: 182–190PubMedCrossRefGoogle Scholar
  30. Grey PC, Dreosti IE (1972) DNA and protein metabolism in Zn-deficient rats. J Comp Pathol 82: 223–228PubMedCrossRefGoogle Scholar
  31. Grummt F, Weinmann-Dorsch C, Schneider -Schaulies J, Lux A (1986) Zinc as a second messenger of mitogenic induction. Exp Cell Res 163: 191–200PubMedCrossRefGoogle Scholar
  32. Hanas JS, Hazuda DJ, Bogenhagen DF, Wu F Y-H, Wu C-W (1983) Xenopus transcription factor A requires Zn for binding to the 5S RNA gene. J Biol Chem 258: 14120–14125PubMedGoogle Scholar
  33. Haskins KM, Zombola RR, Boling JM, Lee YC, Himes RH (1980) Tubulin assembly induced by cobalt and zinc. Biochem Biophys Res Commun 95: 1703–1709PubMedCrossRefGoogle Scholar
  34. Hesketh JE (1981) Impaired microtubule assembly in brain from Zn-deficient pigs and rats. Int J Biochem 13: 921–926PubMedCrossRefGoogle Scholar
  35. Hesketh JE (1982) Zinc stimulated microtubule assembly and evidence for Zn binding to tubulin. Int J Biochem 14: 983–990PubMedCrossRefGoogle Scholar
  36. Hesketh JE (1983) Zinc binding to tubulin. Int J Biochem 15: 743–746PubMedCrossRefGoogle Scholar
  37. Hsu JM, Kim KM, Anthony WL (1974) Biochemical and electron microscopic studies of rat skin during Zn deficiency. Adv Exp Med Biol 48: 347–388PubMedCrossRefGoogle Scholar
  38. Hurley LS, Gowan J, Swenerton H (1971) Teratogenic effects of short-term and transitory zinc deficiency in rats. Teratology 4: 199–204CrossRefGoogle Scholar
  39. Lassar AB, Martin PL, Roeder RG (1983) Transcription of class III genes: formation of pre-initiation complexes. Science 222: 740–748PubMedCrossRefGoogle Scholar
  40. Lieberman I, Ove P (1962) Deoxyribonucleic acid synthesis and its inhibition in mammalian cells cultured from the animal. J Biol Chem 237: 1634–1642PubMedGoogle Scholar
  41. Lieberman I, Abrams R, Hunt N, Ove P (1963) Levels of enzyme activity and deoxyribonucleic acid synthesis in mammalian cells cultured from the animal. J Biol Chem 238: 3955–3962PubMedGoogle Scholar
  42. McQuitty JT, De Wys WD, Monaco L et al. (1970) Inhibition of tumor growth by dietary zinc deficiency. Cancer Res 30: 1387–1390PubMedGoogle Scholar
  43. Masters DG, Keen CL, Lönnerdal B, Hurley LS (1983) Zn deficiency teratogenicity: the protective effect of maternal tissue catabolism. J Nutr 113: 905–912PubMedGoogle Scholar
  44. Miller J, McLachlan AD, Klug A (1985) Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes. EMBO J 4: 1609–1614PubMedGoogle Scholar
  45. Mills BJ, Broghamer WL, Higgins PJ, Lindeman RD (1981) A specific dietary Zn requirement for the growth of Walker 256/M1 tumor in the rat. Am J Clin Nutr 34: 1661–1669PubMedGoogle Scholar
  46. Minkel DJ, Dolhoun PJ, Calhoun BL, Sarayan LA, Petering DH (1979) Zn deficiency and growth of Ehrlich ascites tumors. Cancer Res 39: 2951–2956Google Scholar
  47. Record IR, Dreosti IE (1979) Effects of Zn deficiency on liver and brain thymidine kinase activities in the fetal rat. Nutr Rep Int 20: 749–755Google Scholar
  48. Record IR, Dreosti FE, Manuel SJ, Buckley RA, Tulsi RS (1985) Teratological influence of the feeding cycle in Zn-deficient rats. In: Mills CF, Bremner I, Chesters JK (ed) Trace element metabolism in man and animals — TEMA 5. Commonwealth Bureaux of Nutrition, Slough, pp 210–213Google Scholar
  49. Rubin H (1972) Inhibition of DNA synthesis in animal cells by EDTA and its reversal by Zn. Proc Natl Acad Sci 69: 712–716PubMedCrossRefGoogle Scholar
  50. Rubin H, Koide T (1973) Inhibition of DNA synthesis in chick embryo cultures by deprivation of either serum or zinc. J Cell Biol 56: 777–786PubMedCrossRefGoogle Scholar
  51. Sarayan LA, Minkel DT, Dolhoun PJ et al. (1979) Effects of Zn deficiency on cellular processes and morphology in Ehrlich ascites tumor cells. Cancer Res 39: 2457–2465Google Scholar
  52. Terhune MW, Sandstead HH (1972) Decreased RNA polymerase activity in mammalian Zn deficiency. Science 177: 68–69PubMedCrossRefGoogle Scholar
  53. Vallee BL, Falchuk KH (1981) Zinc and gene expression. Philos Trans R Soc B 294: 185–197CrossRefGoogle Scholar
  54. Vallee BL, Falchuk KH (1983) Gene expression and zinc. In: Sarker B (ed) Biological aspects of metals and metal-related diseases. Raven Press, New York, pp 1–14Google Scholar
  55. Vallee BL, Galdes A (1984) The metallobiochemistry of Zn enzymes. Adv Enzymol 56: 283–430PubMedGoogle Scholar
  56. Weinmann-Dorsch C, Hedl A, Grummt I et al. (1984) Drastic rise in intracellular adenosine 5’ tetraphosphate 5’ adenosine correlates with onset of DNA synthesis in eukaryotic cells. Eur J Biochem 138: 179–185PubMedCrossRefGoogle Scholar
  57. Westmoreland N (1971) Connective tissue alterations in Zn deficiency. Fed Proc Fed Soc Exp Biol Med 30: 1001–1010Google Scholar
  58. Williams RB, Chesters JK (1970) The effects of early zinc deficiency on DNA and protein synthesis in the rat. Br J Nutr 24: 1053–1059PubMedCrossRefGoogle Scholar
  59. Williams RB, Mills CF (1970) The experimental production of zinc deficiency in the rat. Br J Nutr 24: 989–1003PubMedCrossRefGoogle Scholar
  60. Wingender E, Dilloo D, Seifert KH (1984) Zinc ions are differentially required for the transcription of ribosomal 5S RNA and tRNA in a HeLa cell extract. Nucleic Acids Res 12: 8971–8985PubMedCrossRefGoogle Scholar
  61. Yamaguchi N, Kodama M, Ueda K (1985) Diadenosine tetraphosphate as a signal molecule linked with the functional state of rat liver. Gastroenterology 89: 723–731PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

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  • J. K. Chesters

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