Non-specific, Unclassifiable, and Rare Idiopathic Interstitial Pneumonia: Acute Interstitial Pneumonia, Respiratory Bronchiolitis Interstitial Pneumonia, Desquamative Interstitial Pneumonia, Nonspecific Interstitial Pneumonia

  • Curtis J. ColeyII
  • Leslie B. Tolle
  • Jennifer Hasvold
  • Lindsay A. Schmidt
  • Kevin R. Flaherty
Chapter
First Online:

Abstract

Acute interstitial pneumonia (AIP), also called Hamman-Rich syndrome, is a rapidly progressive diffuse parenchymal lung disease of unknown etiology resulting in hypoxemic respiratory failure which is often fatal. Respiratory bronchiolitis interstitial lung disease (RB-ILD) and desquamative interstitial pneumonia (DIP) are believed to be on the same spectrum of disease, and share tobacco use as a common denominator; however there is a significant difference between the morbidity and mortality of the two conditions. Non-specific interstitial pneumonia (NSIP) is a pathologic description of a chronic interstitial pneumonia that lacks the histopathologic features typical of other idiopathic interstitial pneumonias, despite many similarities in clinical and radiographic presentation. This section is gives information regarding the history, epidemiology, definition, clinical presentation, and treatment of acute interstitial pneumonia (AIP), respiratory bronchiolitis interstitial lung disease (RB-ILD), desquamative interstitial pneumonia (DIP), and non-specific interstitial pneumonia (NSIP).

Keywords

Nonspecific Hamman-Rich Bronchiolitis Desquamative Pneumonia Idiopathic Unclassifiable 

Abbreviations

AIP

Acute Interstitial Pneumonia

ARDS

Acute Respiratory Distress Syndrome

BAL

Broncho-Alveolar Lavage

DIP

Desquamative Interstitial Pneumonia

GGO

Ground Glass Opacification

HRCT

High Resolution Computed Tomography

ILD

Interstitial Lung Disease

NSIP

Non-Specific Interstitial Pneumonia

RB

Respiratory Bronchiolitis

RB-ILD

Respiratory Bronchiolitis Interstitial Lung Disease

TPMT

Thiopurine Methyltransferase

UCTD

Undifferentiated Connective Tissue Disease

UIP

Usual Interstitial Pneumonia

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Copyright information

© Springer-Verlag London 2015

Authors and Affiliations

  • Curtis J. ColeyII
    • 1
  • Leslie B. Tolle
    • 2
  • Jennifer Hasvold
    • 1
  • Lindsay A. Schmidt
    • 3
  • Kevin R. Flaherty
    • 4
  1. 1.Internal MedicineUniversity of MichiganAnn ArborUSA
  2. 2.Internal MedicineUniversity of MichiganAnn ArborUSA
  3. 3.Department of PathologyUniversity of MichiganAnn ArborUSA
  4. 4.Department of Internal Medicine, Division of Pulmonary and Critical CareUniversity of MichiganAnn ArborUSA

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