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Broader Considerations of Medical and Dental Data Integration

  • Stephen Foreman
  • Joseph Kilsdonk
  • Kelly Boggs
  • Wendy E. Mouradian
  • Suzanne Boulter
  • Paul Casamassimo
  • Valerie J. H. Powell
  • Beth Piraino
  • Wells Shoemaker
  • Jessica Kovarik
  • Evan(Jake) Waxman
  • Biju Cheriyan
  • Henry Hood
  • Allan G. Farman
  • Matthew Holder
  • Miguel Humberto Torres-Urquidy
  • Muhammad F. Walji
  • Amit Acharya
  • Andrea Mahnke
  • Po-Huang Chyou
  • Franklin M. Din
  • Steven J. Schrodi
Chapter
First Online:
Part of the Health Informatics book series (HI, volume 3)

Abstract

Dental health insurance coverage in the United States is either nonexistent (Medicare and the uninsured), spotty (Medicaid) and limited (most employer-based private benefit plans). Perhaps as a result, dental health in the United States is not good. What public policy makers may not appreciate is that this may well be impacting medical care costs in a way that improved dental benefits would produce a substantial return to investment in expanded dental insurance coverage.

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References

  2. Acharya A, Bhavsar N, Jadav B, Parikh H. Cardioprotective effect of periodontal therapy in metabolic syndrome: a pilot study in Indian subjects. Metab Syndr Relat Disord. 2010;8(4):335–41.PubMedCrossRefGoogle Scholar
  3. Adachi M, Ishihara K, Abe S, Okuda K, Ishikawa T. Effect of professional oral health care on the elderly living in nursing homes. Oral Surg Oral Med Oral Pathol. 2002. doi: 10.1067/moe.2002.123493.
  4. Aetna. Study shows preventive dental care may help reduce risk of preterm birth. 2008. http://www.aetna.com/news/newsReleases/2008/1001_DMI_Preterm_Birth_Risk.html. Accessed 26 June 2011.
  5. Aggarwal V, Joughin A, Zakrzewska J, Crawford F, Tickle M. Dentists’ and specialists’ knowledge of chronic orofacial pain: results from a continuing professional development survey. Prim Dent Care. 2011;18(1):41–4.PubMedCrossRefGoogle Scholar
  6. Albert DA, Sadowsky D, Papapanou P, Conicella ML, Ward A. An examination of periodontal treatment and per member per month (PMPM) medical costs in an insured population. BMC Health Serv Res. 2006;6(103):1–10. doi: 10.1186/1472-6963-6-103.Google Scholar
  7. Albert DA, Begg MD, Andrews HF, Williams SZ, Ward A, Conicella ML, Rauh V, Thomson JL, Papapanou PN. An examination of periodontal treatment, dental care, and pregnancy outcomes in an insured population in the united states. Am J Public Health. 2011. doi: 10.2105/AJPH.2009.185884.
  8. Al-Humayed S, Mohamed-Elbagir A, Al-Wabel A, Argobi Y. The changing pattern of upper gastro-intestinal lesions in Southern Saudi Arabia: an endoscopic study. Saudi J Gastroenterol. 2010;16(1):35–7.PubMedCrossRefGoogle Scholar
  9. Amer A, Singh G, Darke C, Dolby AE. Association between HLA antigens and periodontal disease. Tissue Antigens. 1988;31(2):53–8.PubMedCrossRefGoogle Scholar
  10. Anderson G. Chronic care: making the case for ongoing care. Princeton: Robert Wood Johnson Foundation; 2010.Google Scholar
  11. Andraws R, Berger JS, Brown DL. Effects of antibiotic therapy on outcomes of patients with coronary artery disease: a meta-analysis of randomized controlled trials. JAMA. 2005;293(21):2641–7.PubMedCrossRefGoogle Scholar
  12. Andriankaja OM, Sreenivasa S, Dunford R, DeNardin E. Association between metabolic syndrome and periodontal disease. Aust Dent J. 2010;55(3):252–9.PubMedCrossRefGoogle Scholar
  13. Anjomshoaa I, Cooper ME, Vieira AR. Caries is associated with asthma and epilepsy. Eur J Dent. 2009;3:297–303.PubMedGoogle Scholar
  14. Ashkenazy R, Abrahamson M. Medicare coverage for patients with diabetes. J Gen Intern Med. 2006;21:386–94.PubMedCrossRefGoogle Scholar
  15. Bach J-F. Infections and autoimmune diseases. J Autoimmun. 2005;25(1):74–80.PubMedCrossRefGoogle Scholar
  16. Bailit HL, Beazoglou TJ, Formicola AJ, Tedesco LA, Brown LJ, Weaver RG. U.S. state-supported dental schools: financial projections and implications. J Dent Educ. 2008;72(2 Suppl):98–109.PubMedGoogle Scholar
  17. Baker EL, Koplan JP. Strengthening the Nation’s public health infrastructure: historic challenge, unprecedented opportunity. Health Aff. 2002;21(6):15–27.CrossRefGoogle Scholar
  18. Barnett WS, Brown KC. Dental health policy analysis series: issues in children’s access to dental care under Medicaid. Chicago: American Dental Association; 2000.Google Scholar
  19. Baum BJ. Inadequate training in the biological sciences and medicine for dental students. J Am Dent Assoc. 2007;138:16–25.PubMedGoogle Scholar
  20. Bayer R, Colgrove J. Bioterrorism, public health and the law. Health Aff. 2002;21(6):98–101.CrossRefGoogle Scholar
  21. Begovich AB, Carlton VEH, Honigberg LA, Schrodi SJ, et al. A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet. 2004;75(2):330–7.PubMedCrossRefGoogle Scholar
  22. Bestor TH. The DNA methyltransferases of mammals. Hum Mol Genet. 2000;9(16):2395–402.PubMedCrossRefGoogle Scholar
  23. Betts RK. Fixing intelligence, foreign affairs, January/February. 2002. URL: http://www.foreignaffairs.org/20020101faessay6556/richard-k-betts/fixing-intelligence.html?mode=print. Accessed May 2011.
  24. Bibikova M, Lin Z, Zhou L, Chudin E, et al. High-throughput DNA methylation profiling using universal bead arrays. Genome Res. 2006;16(3):383–93.PubMedCrossRefGoogle Scholar
  25. Blue Cross Blue Shield of Michigan. Study links good oral care to lower diabetes care costs. 2009. http://www.bcbsm.com/pr/pr_08-27-2009_71090.shtml. Accessed 26 June 2011.
  26. Bollen CM, Rompen EH, Demanez JP. Halitosis: a multidisciplinary problem. Rev Med Liege. 1999;54(1):32–6.PubMedGoogle Scholar
  27. Botstein D, White RL, Skolnick M, Davis RW. Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet. 1980;32(3):314–31.PubMedGoogle Scholar
  28. Bretz WA, Corby PM, Schork NJ, Robinson MT, et al. Longitudinal analysis of heritability for dental caries traits. J Dent Res. 2005a;84(11):1047–51.PubMedCrossRefGoogle Scholar
  29. Bretz WA, Weyant RJ, Corby PM, Ren D, et al. Systemic inflammatory markers, periodontal diseases, and periodontal infections in an elderly population. J Am Geriatr Soc. 2005b;53:1532–7.PubMedCrossRefGoogle Scholar
  30. Broadwater C. Attention to dental coverage lacking in health-care debate. From St. Petersburg Times. 2009. http://www.tampabay.com/news/health/attention-to-dental-coverage-lacking-in-health-care-debate/1048349. Retrieved Mar 21 2011.
  31. Brodeur P. Community based dental education: the pipeline, profession and practice program. Robert Wood Johnson Foundation. 2008. http://www.rwjf.org/files/research/anthology2009.chapter8.pdf. Accessed 26 June 2011.
  32. Brown GC, Brown MM, Hiller T, Fischer D, Benson W, Magargal L. Cotton-wool spots. Retina. 1985;5(4):206–14.PubMedCrossRefGoogle Scholar
  33. Cargill M, Schrodi SJ, Chang M, Garcia VE, et al. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet. 2007;80(2):273–90.PubMedCrossRefGoogle Scholar
  34. Carroll L. Mother’s gum disease linked to infant’s death. 2010. http://www.msnbc.msn.com/id/34979552/ns/health-oral_health/. Accessed 26 June 2011.
  35. Cartwright-Smith L. Chronic disease management. Health reform GPS: navigating the implementation process. 2011. http://www.healthreformgps.org/resources/chronic-disease-management/. Accessed 25 June 2011.
  36. Carvalho FM, Tinoco EMB, Deeley K, Duarte PM, et al. FAM5C contributes to aggressive periodontitis. PLoS One. 2010;5(4):e10053.PubMedCrossRefGoogle Scholar
  37. Center for Medicare and Medicaid Services. Data compendium. Washington, D.C.: US Government Printing Office; 2010.Google Scholar
  38. Center for Medicare and Medicaid Services. Medicare physician group practice demonstration. 2010. http://www.cms.gov/DemoProjectsEvalRpts/downloads/PGP_Fact_Sheet.pdf. Accessed 25 June 2011.
  39. Centers for Disease Control. Dental service use and dental insurance coverage-United States, behavioral risk factor surveillance system. MMWR Morb Mortal Wkly Rep. 1997;46(50):1199–203.Google Scholar
  40. Chaffee BW, Weston SJ. Association between chronic periodontal disease and obesity: a systematic review and meta-analysis. J Periodontol. 2010;81(12):1708–24.PubMedCrossRefGoogle Scholar
  41. Chapman WW, Bridewell W, Hanbury P, Cooper GF, Buchanan BG. Evaluation of negation phrases in narrative clinical reports. Proc AMIA Symp. 2001;105–9.Google Scholar
  42. Chasteen JE, Murphy G, Forrey A, Heid D. The health insurance and portability and accountability act: practice of dentistry in the united states: privacy and confidentiality. J Contemp Dent Pract. 2003;1(4):059–70.Google Scholar
  43. Chen T, Yu W-H, Izard J, Baranova OV, et al. The human oral microbiome database: a web accessible resource for investigating oral microbiome taxonomic and genomic information. Database (Oxford). 2010;Article ID baq013.Google Scholar
  44. Cheng Y, Hootman J, Murphy L, Langmaid G, Helmick C, Centers for Disease Control and Prevention (CDC). Prevalence of doctor diagnosed arthritis and arthritis attributable activity limitation – United States, 2007–2009. MMWR Morb Mortal Wkly Rep. 2010;59(39):1–2.Google Scholar
  45. CIGNA. CIGNA dental oral health maternity program. 2006. http://www.cigna.com/our_plans/programs/dental_health/oral_health_maternity_program.html. Accessed 26 June 2011.
  46. Cisternas M, Murphy L, Yelin E, Foreman A, Pasta D, Helmick C. Trends in medical care expenditures of US adults with arthritis and other rheumatic conditions 1997 to 2005. J Rheumatol. 2009;36(11):2531–8.PubMedCrossRefGoogle Scholar
  47. Cloos J, Spitz MR, Schantz SP, Hsu TC, et al. Genetic susceptibility to head and neck squamous cell carcinoma. J Natl Cancer Inst. 1996;88:530–5.PubMedCrossRefGoogle Scholar
  48. Connelly JJ, Shah SH, Doss JF, Gadson S, et al. Genetic and functional association of FAM5C with myocardial infarction. BMC Med Genet. 2008;9:33.PubMedCrossRefGoogle Scholar
  49. Corey LA, Nance WE, Hofstede P, Schenkein HA. Self-reported periodontal disease in a Virginia twin population. J Periodontol. 1993;64:1205–8.PubMedGoogle Scholar
  50. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420:860–7.PubMedCrossRefGoogle Scholar
  51. Crawford PJM, Aldred M, Bloch-Zupan A. Amelogenesis imperfecta. Orphanet J Rare Dis. 2007;2:17.PubMedCrossRefGoogle Scholar
  52. Crosby AH, Scherpbier-Heddema T, Wijmenga C, Altherr MR, et al. Genetic mapping of the dentinogenesis imperfecta type II locus. Am J Hum Genet. 1995;57:832–9.PubMedGoogle Scholar
  53. D’Aiuto F, Sabbah W, Netuveli G, Donos N, et al. Association of the metabolic syndrome with severe periodontitis in a large U.S. population-based survey. J Clin Endocrinol Metab. 2008;93(1):3989–94.PubMedCrossRefGoogle Scholar
  54. Dall T, Zhang Y, Chen J, Quick W, Yang W, Fogli J. The economic burden of diabetes. Health Aff. 2010;29(2):297–304.CrossRefGoogle Scholar
  55. Dannenberg AJ, Subbaramaiah K. Targeting cyclooxygenase-2 in human neoplasia: rationale and promise. Cancer Cell. 2003;4(6):431–6.PubMedCrossRefGoogle Scholar
  56. Delanghe G, Ghyselen J, Bollen C, van Steenberghe D, Vandekerckhove BN, Feenstra L. An inventory of patients’ response to treatment at a multidisciplinary breath odor clinic. Quintessence Int. 1999;30(5):307–10.PubMedGoogle Scholar
  57. Delrose DC, Steinberg RW. The clinical significance of the digital patient record. J Am Dent Assoc. 2000;131(sup):57S–60.PubMedGoogle Scholar
  58. Delta Dental of Wisconsin. Evidence-based integrated care plan. 2011. http://www.deltadentalwi.com/EBICP. Accessed 26 June 2011.
  59. Dental, Oral and Craniofacial Data Resource Center of the National Institute of Dental and Craniofacial Research. Oral health US, 2002. Washington, D.C.: US Government Printing Office; 2002.Google Scholar
  60. Dentistry Today. Buyers’ guide to dental software. Dent Today. 2003;22(9):126–39.Google Scholar
  61. Dentrix Dental Systems (2011). HIPAA. URL: http://www.dentrix.com/support/hipaa.aspx Accessed May 2011Google Scholar
  62. Dentrix Dental Systems. HIPAA. 2003. URL: http://www.dentrix.com/support/hipaa.aspx. Accessed May 2011.
  63. Department of Veterans Affairs. VA health information technology improves quality of health care while reducing costs. 2010. http://www1.va.gov/opa/pressrel/pressrelease.cfm?id=1881. Accessed 26 June 2011.
  64. DeStefano F, Anda R, Kahn H, Williamson D, Russell C. Dental disease and risk of coronary heart disease and mortality. Br Med J. 1993;306:688–92.CrossRefGoogle Scholar
  65. Dictor M. Human herpesvirus 8 and Kaposi’s sarcoma. Seim Cutan Med Surg. 1997;16(3):181–7.CrossRefGoogle Scholar
  66. Dunning DG, Durham TM, Lange BM, Aksu MN. Strategic management and organizational behavior in dental education: reflections on key issues in an environment of change. J Dent Educ. 2009;73:689–95.PubMedGoogle Scholar
  67. Eaton CB, Feldman HA, Assaf AR, McPhillips JB, et al. Prevalence of hypertension, dyslipidemia, and dyslipidemic hypertension. J Fam Pract. 1994;38(1):17–23.PubMedGoogle Scholar
  68. Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet. 2005;365(9468):1415–28.PubMedCrossRefGoogle Scholar
  69. eHow. About Medicaid dental coverage. From Health. 2011. http://www.ehow.com/about_5070293_medicaid-dental-coverage.html. Retrieved Mar 21 2011
  70. Ehrich M, Nelson MR, Stanssens P, Zabeau M, et al. Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry. Proc Natl Acad Sci USA. 2005;102(44):15785–90.PubMedCrossRefGoogle Scholar
  71. Elia J, Gai X, Xie HM, Perin JC, et al. Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes. Mol Psychiatry. 2010;15:637–46.PubMedCrossRefGoogle Scholar
  72. Ernst FD, Uhr K, Teumer A, Fanghanel J, et al. Replication of the association of chromosomal region 9p21.3 with generalized aggressive periodontitis (gAgP) using an independent case-control cohort. BMC Genet. 2010;11:119.CrossRefGoogle Scholar
  73. Errante JV. Integration of medical and dental benefits for improved overall health. Institute for Oral Health. 2007. http://www.institutefororalhealth.org/2007/ppt/IOH07_Errante.pdf. Accessed 26 June 2011
  74. Etzioni A. Public health Law: a communitarian perspective. Health Aff. 2002;21(6):102–4.CrossRefGoogle Scholar
  75. Falconer DS, MacKay TFC. Introduction to quantitative genetics. 4th ed. Essex: Harlow; 1996.Google Scholar
  76. Ferrannini E, Haffner SM, Mitchell BD, Stern MP. Hyperinsulinaemia: the key feature of a cardiovascular and metabolic syndrome. Diabetologia. 1991;34(6):416–22.PubMedCrossRefGoogle Scholar
  77. Field MJ. Dental education at the crossroads: challenges and change. An Institute of Medicine Report. Washington, D.C.: National Academy Press; 1995.Google Scholar
  78. Firestein GS. Evolving concepts of rheumatoid arthritis. Nature. 2003;423:356–61.PubMedCrossRefGoogle Scholar
  79. Fischer J, Blanchet-Bardon C, Prud’homme J-F, Pavek S, et al. Mapping of papillon-lefevre syndrome to the chromosome 11q14 region. Eur J Hum Genet. 1997;5:156–60.PubMedGoogle Scholar
  80. Fisher ES. Building a medical neighborhood for the medical home. N Engl J Med. 2008;359(12):1202–5. doi: 10.1056/NEJMp0806233.PubMedCrossRefGoogle Scholar
  81. Fisher MA, Taylor GW, Est BT, McCarthy ET. Bidirectional relationship between chronic kidney and periodontal disease: a study using structural equation modeling. Kidney Int. 2011;79:347–55.PubMedCrossRefGoogle Scholar
  82. Fitzgerald M, Piskorowski W. Clinical outreach: seven years of a self-sustaining model. J Dent Educ. 2009;73:249.Google Scholar
  83. Flores S, Mills SE, Shackelford L. Dentistry and bioterrorism. Dent Clin North Am. 2003;47(4):733–44.PubMedCrossRefGoogle Scholar
  84. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults. JAMA. 2002;287(3):356–9.PubMedCrossRefGoogle Scholar
  85. Formicola AJ, Bailit H, Beazoglou T, Tedesco LA. The Macy study: a framework for consensus. J Dent Educ. 2005;69:1183–5.PubMedGoogle Scholar
  86. Frieden J. CMS projects focus on chronic illnesses: three demonstration projects seek to improve efficiency and care. Caring for ages. 2006. http://www.caringfortheages.com/news/geriatric-medicine/single-article/cms-projects-focus-on-chronic-illnesses-three-demonstration-projects-seek-to-improve-efficiency-and-care/7be973db97ab1f83fd4473b96d58e48a.html. Accessed 25 June 2011.
  87. Friedenberg FK, Rai J, Vanar V, Bongiorno C, Nelson DB, Parepally M, et al. Prevalence and risk factors for gastroesophageal reflux disease in an impoverished minority population. Obes Res Clin Pract. 2010;4(4):e261–9.PubMedCrossRefGoogle Scholar
  88. Frist B. Public health and national security: the critical role of increased federal support. Health Aff. 2002;21(6):117–30.CrossRefGoogle Scholar
  89. Furr MC, Larkin E, Blakeley R, Albert TW, Tsugawa L, Weber SM. Extending multidisciplinary management of cleft palate to the developing world. J Oral Maxillofac Surg. 2011;69(1):237–41.PubMedCrossRefGoogle Scholar
  90. Gesteland PH, Gardner RM, Tsui FC, Espino JU, Rolfs RT, James BC, Chapman WW, Moore AW, Wagner MM. Automated syndromic surveillance for the 2002 winter olympics. J Am Med Inform Assoc. 2003;10(6):547–54.PubMedCrossRefGoogle Scholar
  91. Ghezzi EM, Ship JA. Systemic diseases and their treatment in the elderly: impact on oral health. J Public Health Dent. 2000;60(4):297–303.CrossRefGoogle Scholar
  92. Gies W. Dental education in the United States and Canada. 1926. http://www.adeagiesfoundation.org/about/Pages/AboutWilliamJGiesandtheGiesReport.aspx. Accessed 26 June 2011.
  93. Goldenberg A, Shmueli G, Caruana RA, Fienberg SE. Early statistical detection of anthrax outbreaks by tracking over-the-counter medication sales. Proc Natl Acad Sci USA. 2002;99(8):5237–40.PubMedCrossRefGoogle Scholar
  94. Gomez RS, Dutra WO, Moreira PR. Epigenetics and periodontal disease: future perspectives. Inflamm Res. 2009;58:625–9.PubMedCrossRefGoogle Scholar
  95. Gonzalez E, Kulkarni H, Bolivar H, Mangano A, et al. The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility. Science. 2005;307:1434–40.PubMedCrossRefGoogle Scholar
  96. Graham RR, Cotsapas C, Davies L, Hackett R, et al. Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus. Nat Genet. 2008;40:1059–61.PubMedCrossRefGoogle Scholar
  97. Grant SFA, Thorleifsson G, Reynisdottir I, Benediktsson R, et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet. 2006;38:320–3.PubMedCrossRefGoogle Scholar
  98. Gregory SG, Schmidt S, Seth P, Oksenberg JR, et al. Interleukin 7 receptor α chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet. 2007;39:1083–91.PubMedCrossRefGoogle Scholar
  99. Grubbs V, Plantinga LC, Crews DC, Bibbins-Domingo K, Saran R, Heung M, Patel PR, Burrows NR, Ernst KL, Powe NR, for the Centers for Disease Control and Prevention CKD Surveillance Team. Vulnerable populations and the association between periodontal and chronic kidney disease. Clin J Am Soc Nephrol. 2011;6:711–7.PubMedCrossRefGoogle Scholar
  100. Guay AH. Dentistry’s response to bioterrorism: a report of a consensus workshop. J Am Dent Assoc. 2002;133:1181–1187.Google Scholar
  101. Gudmundsson J, Sulem P, Gudbjartsson DF, Blondal T, et al. Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility. Nat Genet. 2009;41:1122–6.PubMedCrossRefGoogle Scholar
  102. Ha PK, Califano JA. Promoter methylation and inactivation of tumour-suppressor genes in oral squamous-cell carcinoma. Lancet Oncol. 2006;7:77–82.PubMedCrossRefGoogle Scholar
  103. Hammoud SS, Nix DA, Zhang H, Purwar J, et al. Distinctive chromatin in human sperm packages genes for embryo development. Nature. 2009;460:473–8.PubMedGoogle Scholar
  104. Hart TC, Hart PS, Michalec MD, Zhang Y, et al. Localisation of a gene for prepubertal periodontitis to chromosome 11q14 and identification of a cathepsin C gene mutation. J Med Genet. 2000;37(2):95–101.PubMedCrossRefGoogle Scholar
  105. Heid DW, Chasteen J, Forrey AW. The electronic oral health record. J Contemp Dent Pract. 2002;1(3):043–54.Google Scholar
  106. Helgadottir A, Thorleifsson G, Manolescu A, Gretarsdottir S, et al. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science. 2007;316(5830):1491–3.PubMedCrossRefGoogle Scholar
  107. Hewitt C, McCormick D, Linden G, Turk D, et al. The role of cathepsin C in papillon-lefevre syndrome, prepubertal periodontitis, and aggressive periodontitis. Hum Mutat. 2004;23(3):222–8.PubMedCrossRefGoogle Scholar
  108. Hinds DA, Stuve LL, Nilsen GB, Halperin E, et al. Whole-genome patterns of common DNA variation in three human populations. Science. 2005;307(5712):1072–9.PubMedCrossRefGoogle Scholar
  109. Hirschhorn JN, Lohmueller K, Byrne E, Hirschhorn K. A comprehensive review of genetic association studies. Genet Med. 2002;4(2):45–61.PubMedCrossRefGoogle Scholar
  110. Hogan P, Dall T, Nikolov P. Economic cost of babies in the US in 2002. Alexandria: American Diabetes Association; 2002.Google Scholar
  111. Holder M, Waldman H, Hood H. Preparing health professionals to provide care to individuals with disabilities. Int J Oral Sci. 2009;1(2):54–9.Google Scholar
  112. Holt SC, Ebersole JL. Porphyromonas gingivalis, Treponema denticola, and Tennerella forsythia: the “red complex”, a prototype polybacterial pathogenic consortium in periodontitis. Periodontol. 2005;38:72–122.PubMedCrossRefGoogle Scholar
  113. Holvoet P, Lee DH, Steffes M, Gross M, Jacobs Jr DR. Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndrome. JAMA. 2008;299(19):2287–93.PubMedCrossRefGoogle Scholar
  114. Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444:860–7.PubMedCrossRefGoogle Scholar
  116. Hudson RR. Gene genealogies and the coalescent process. In: Futuyma D, Antonovics J, editors. Oxford surveys in evolutionary biology, vol. 7. New York: Oxford University Press; 1991. p. 1–44.Google Scholar
  117. Hund H, Willett W, Merchant A, Rosner B, Ascherio A, Joshipura K. Oral health and a referral arterial disease. Circulation. 2003;107:1152–9.CrossRefGoogle Scholar
  118. Ide R, Hoshuyama T, Takakhashi K. The effect of periodontal disease on medical and dental costs in a middle-aged japanese population: a longitudinal worksite study. J Periodontol. 2007;78(11):2120–6. doi: 10.1902/jop. 2007.070193.PubMedCrossRefGoogle Scholar
  119. Independent Task Force. Council on foreign relations “America-still unprepared, still in danger”. 2011. URL: http://www.cfr.org/pdf/Homeland_Security_TF.pdf. Accessed May 2011.
  120. Institute for Oral Health. Focus Groups on Oral Health in Healthcare Reform – Focus Group #2. 2010. http://www.institutefororalhealth.org/2010fg/IOH-APR2010-Focus-Group-whitepaper.pdf. Accessed 26 June 2011.
  121. Ivanov O, Wagner MM, Chapman WW, Olszewski RT. Accuracy of three classifiers of acute gastrointestinal syndrome for syndromic surveillance. Proc AMIA Symp. 2002; 345–9.Google Scholar
  122. Iwamoto Y, Nishimura F, Nakagawa M, Sugimoto K, et al. The effect of antimicrobial periodontal treatment on circulating tumor necrosis factor-alpha and glycated hemoglobin level in patients with type 2 diabetes. J Periodontol. 2001;72(6):774–8.PubMedCrossRefGoogle Scholar
  123. Jemal A, Siegel R, Ward E, Hao Y, et al. Cancer statistics, 2009. CA Cancer J Clin. 2009;59:225–49.PubMedCrossRefGoogle Scholar
  124. Jones HB. The relative power of linkage and association studies for the detection of genes involved in hypertension. Kidney Int. 1998;53:1446–8.PubMedCrossRefGoogle Scholar
  125. Joshipura K, Hung H, Rimm E, Willett W, Ascherio A. Periodontal disease, tooth loss and incidence of ischemic stroke. Stroke. 2003;34:47–54.PubMedCrossRefGoogle Scholar
  126. Josiah Macy Foundation. New models of dental education. 2004. http://www.josiahmacyfoundation.org/grantees/profile/new-models-for-dental-education. Accessed 26 June 2011.
  127. Kaiser Family Foundation. The uninsured. Washington, D.C.: The Henry J. Kaiser Family Foundation; 2010.Google Scholar
  128. Kaplan NL, Hill WG, Weir BS. Likelihood methods for locating disease genes in nonequilibrium populations. Am J Hum Genet. 1995;56:18–32.PubMedGoogle Scholar
  129. Kathiresan S, Melander O, Guiducci C, Surti A, et al. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet. 2008;40:189–97.PubMedCrossRefGoogle Scholar
  130. Kim JW, Simmer JP, Hu YY, Lin BP, et al. Amelogenin p.M1T and p.W4S mutations underlying hypoplastic X-linked amelogenesis imperfecta. J Dent Res. 2004;83(5):378–83.PubMedCrossRefGoogle Scholar
  131. Kim DS, Cheang P, Dover S, Drake-Lee AB. Dental otalgia. J Laryngol Otol. 2007;121(12):1129–34.PubMedCrossRefGoogle Scholar
  132. Kimura M. Stochastic processes in population genetics, with special reference to distribution of gene frequencies and probability of gene fixation. In: Kojima K, editor. Mathematical topics in population genetics. Berlin/New York: Springer; 1970. p. 178–245.Google Scholar
  133. Klein RJ, Zeiss C, Chew EY, Tsai J-Y, et al. Complement factor H polymorphism in age-related macular degeneration. Science. 2005;308(5720):385–9.PubMedCrossRefGoogle Scholar
  134. Kruglyak L. Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nat Genet. 1999;22(2):139–44.PubMedCrossRefGoogle Scholar
  135. Kshirsagar AV, Craig RG, Moss KL, et al. Periodontal disease adversely affects the survival of patients with end-stage renal disease. Kidney Int. 2009;75:746–51.PubMedCrossRefGoogle Scholar
  136. Kumar PS, Griffen AL, Barton JA, Paster BJ, et al. New bacterial species associated with chronic periodontitis. J Dent Res. 2003;82(5):338–44.PubMedCrossRefGoogle Scholar
  137. Kuroiwa T, Yamamoto N, Onda T, Shibahara T. Expression of the FAM5C in tongue squamous cell carcinoma. Oncol Rep. 2009;22(5):1005–11.PubMedGoogle Scholar
  138. Laass MW, Hennies HC, Preis S, Stevens HP, et al. Localisation of a gene for papillon-lefevre syndrome to chromosome 11q14-q21 by homozygosity mapping. Hum Genet. 1997;101:376–82.PubMedCrossRefGoogle Scholar
  139. Laine DI, Busch-Petersen J. Inhibitors of cathepsin C (dipeptidyl peptidase I). Expert Opin Ther Pat. 2010;20(4):497–506.PubMedCrossRefGoogle Scholar
  140. Laine ML, Loos BG, Crielaard W. Gene polymorphisms in chronic periodontitis. Int J Dent. 2010;1–22. Article ID 324719.Google Scholar
  141. Lakshminarayanan R, Bromley KM, Lei Y-P, Snead ML, Moradian-Oldak J. Perturbed amelogenin secondary structure leads to uncontrolled aggregation in amelogenesis imperfecta mutant proteins. J Biol Chem. 2010;285:40593–603.PubMedCrossRefGoogle Scholar
  142. Lander ES, Linton LM, Birren B, Nusbaum C, et al. Initial sequencing and analysis of the human genome. Nature. 2001;409:860–921.PubMedCrossRefGoogle Scholar
  143. Lane CH, Fauci AS. Bioterrorism on the home front a new challenge for American medicine. JAMA. 2001;286(20):2595–7.PubMedCrossRefGoogle Scholar
  144. Lang N, Bartold PM, Cullinan M, Jeffcoat M, et al. Consensus report: aggressive periodontitis. Ann Periodontol. 1999;4(1):53.CrossRefGoogle Scholar
  145. Letter from the President. White House. 2002. URL: http://web.archive.org/web/20031224053212/ http://www.whitehouse.gov/homeland/book/letterfromthepresident.pdf. Accessed May 2011.
  146. Leung H, Wang JJ, Rochtchina E, Wong TY, Klein R, Mitchell P. Impact of current and past blood pressure on retinal arteriolar diameter in an older population. J Hypertens. 2004;22:1543–9.PubMedCrossRefGoogle Scholar
  147. Li Y, Xu L, Hasturk H, Kantarci A, et al. Localized aggressive periodontitis is linked to human chromosome 1q25. Hum Genet. 2004;114(3):291–7.PubMedCrossRefGoogle Scholar
  148. Lloyd-Jones D, Adams R, Brown T, Carnethon M, Dai S, DeSimone G, et al. Heart disease & stroke statistics – 2010 update. Circulation. 2010;121:e46–215.PubMedCrossRefGoogle Scholar
  149. Long AD, Langley CH. The power of association studies to detect the contribution of candidate genetic loci to variation in complex traits. Genome Res. 1999;9:720–31.PubMedGoogle Scholar
  150. Looks JW. BioSense – a national initiative for early detection and quantification of public health emergencies. MMWR Morb Mortal Wkly Rep. 2004;53(suppl):53–5.Google Scholar
  151. Lopez NJ, Da Silva I, Ipinza J, Gutierrez J. Periodontal therapy reduces the rate of preterm low birth weight in women with pregnancy-associated gingivitis. J Periodontol. 2005;76 Suppl 11:2144–53.PubMedCrossRefGoogle Scholar
  152. Lopez-Escamez JA. A variant of PTPN22 gene conferring risk to autoimmune diseases may protect against tuberculosis. J Postgrad Med. 2010;56:242–3.PubMedGoogle Scholar
  153. Lumpkin JR. Air, water, places, and data—public health in the information age. J Public Health Manag Pract. 2001;7(6):22–30.PubMedGoogle Scholar
  154. Lukic M, Segec A, Segeca I, Pinotic L, Pinotic K, Atalic B, et al. The role of the nutrition in the pathogenesis of gastroesophageal reflux disease, Barrett’s oesophagus and oesophageal adenocarcinoma. Coll Antropol. 2010;34(3):905–9.PubMedGoogle Scholar
  155. Lupski JR. Structural variation in the human genome. N Engl J Med. 2007;356:1169–71.PubMedCrossRefGoogle Scholar
  156. Machulla HK, Stein J, Gautsch A, Langner J, et al. HLA-A, B, Cw, DRB1, DRB3/4/5, DQB1 in German patients suffering from rapidly progressive periodontitis (RPP) and adult periodontitis (AP). J Clin Periodontol. 2002;29(6):573–9.PubMedCrossRefGoogle Scholar
  157. Manolio TA, Collins FS, Cox NJ, Goldstein DB, et al. Finding the missing heritability of complex diseases. Nature. 2009;461:747–53.PubMedCrossRefGoogle Scholar
  158. Manski R. Dental insurance: design, need and public policy. J Am Coll Dent. 2001;69(9):9–13.Google Scholar
  159. Martin JA, Hamilton BE, Sutton PD, Ventura SJ, et al. Births: final data for 2006. National vital statistics reports; vol 57 no 7. Hyattsville: National Center for Health Statistics. 2009.Google Scholar
  160. McBride M. VA uses integrated health informatics to produce $3 billion in savings. Daily break. 2011. http://www.darkdaily.com/va-uses-integrated-health-informatics-to-produce-3-billion-in-savings-12811. Accessed 26 June 2011.
  161. McPherson R, Pertsemlidis A, Kavasalar N, Stewart A, et al. A common allele on chromosome 9 associated with coronary heart disease. Science. 2007;316(5830):1488–91.PubMedCrossRefGoogle Scholar
  162. Meade JL, de Wynter EA, Brett P, Sharif SM, et al. A family with papillon-lefevre syndrome reveals a requirement for cathepsin C in granzyme B activation and NK cell cytolytic activity. Blood. 2006;107(9):3665–8.PubMedCrossRefGoogle Scholar
  163. Mealey B, Rose L. Diabetes mellitius and inflammatory periodontal diseases. Curr Opin Endocrinol Diabetes Obes. 2008;15:135–41.PubMedCrossRefGoogle Scholar
  164. Mertz E, O’Neil E. The growing challenge of providing oral health care services to all Americans. Health Aff. 2002;21(5):65–77.CrossRefGoogle Scholar
  165. Michalowicz BS, Aeppli D, Virag JG, Klump DG, et al. Periodontal findings in adult twins. J Periodontol. 1991;62:293–9.PubMedGoogle Scholar
  166. Michalowicz BS, Diehl SR, Gunsolley JC, Sparks BS, et al. Evidence of a substantial genetic basis for risk of adult periodontitis. J Periodontol. 2000;71:1699–707.PubMedCrossRefGoogle Scholar
  167. Michigan Dental Association. Woman’s Death Spotlights Need to Restore Adult Dental Medicaid Benefits, Smile Michigan, October 22, 2009. http://www.smilemichigan.com/NewsArticles/Archives/tabid/429/articleType/ArticleView/articleId/377/Womans-Death-Spotlights–Need-to-RestoreBRAdult-Dental-Medicaid-Benefits.aspx. Accessed 21 June, 2011.PubMedCrossRefGoogle Scholar
  168. Miller L, Manwell M, Newbold D. The relationship between reduction in periodontal inflammation and diabetes control: a report of 9 cases. J Periodontol. 1992;63:843–8.PubMedGoogle Scholar
  169. Mombelli A, Casagni F, Madianos PN. Can presence or absence of periodontal pathogens distinguish between subjects with chronic and aggressive periodontitis? A systematic review. J Clin Periodontol. 2002;29:10–21.PubMedCrossRefGoogle Scholar
  170. Montana Business Journal. Employer survey on health insurance in Montana. 2006. From the free library: http://www.thefreelibrary.com/2006+Employer+Survey+on+health+insurance+in+Montana.-a0172012572. Retrieved Mar 21 2011.
  171. Mucci LA, Bjorkman L, Douglass CW, Pedersen NL. Environmental and heritable factors in the etiology of oral diseases – a population-based study of Swedish twins. J Dent Res. 2005;84(9):800–5.PubMedCrossRefGoogle Scholar
  172. Mullins C, Cohen L, Magder L, Manski R. Medicaid coverage and utilization of adult dental services. J Health Care Poor Underserved. 2004;15(4):672–88.PubMedCrossRefGoogle Scholar
  173. Nadeau JH. Transgenerational genetic effects on phenotypic variation and disease risk. Hum Mol Genet. 2009;18:R202–10.PubMedCrossRefGoogle Scholar
  174. Nagelberg RH (2011) The convergence of dental and medical care. Dental Economics.Google Scholar
  175. Narcisi JP. The American dental association’s commitment to electronic data interchange. J Dent Educ. 1996;60(1):28–32.PubMedGoogle Scholar
  176. National Institute of Dental and Craniofacial Research. Dentistry’s role in responding to bioterrorism and other catastrophic events. 2004. URL: http://www.nidcr.nih.gov/CareersAndTraining/DentistryCatastrophicEvents.htm. Accessed May 2011.
  177. National Institute of Dental and Craniofacial Research. (2011). National Institutes of Health Website: http://www.nidcr.nih.gov/DataStatistics/FindDataByTopic/DentalCaries/. Accessed 18 June 2011.
  178. Nesbitt MJ, Reynolds MA, Shiau H, Choe K, et al. Association of periodontitis and metabolic syndrome in the Baltimore longitudinal study of aging. Aging Clin Exp Res. 2010;22(3):238–42.PubMedGoogle Scholar
  179. Ng SB, Buckingham KJ, Lee C, Bigham AW, et al. Exome sequencing identifies the cause of a mendelian disorder. Nat Genet. 2010;42(1):30–5.PubMedCrossRefGoogle Scholar
  180. Nikolopoulos GK, Dimou NL, Hamodrakas SJ, Bagos PG. Cytokine gene polymorphisms in periodontal disease: a meta-analysis of 53 studies including 4178 cases and 4590 controls. J Clin Periodontol. 2008;35(9):754–67.PubMedCrossRefGoogle Scholar
  181. Oral Health America. Keep America smiling: oral health in America. Chicago: Oral Health America; 2003.Google Scholar
  182. Paju S, Scannapeico F. Oral biofilms, periodontitis and pulmonary infections. Oral Dis. 2007;13(6):508–12.PubMedCrossRefGoogle Scholar
  183. Palmer C. Dental leaders review roles in bioterrorism response. American Dental Association NEWS. 2003. ADA.org URL: http://web.archive.org/web/20060219190632/, http://www.ada.org/prof/resources/pubs/adanews/adanewsarticle.asp?articleid=390. Accessed May 2011.
  184. Partnership for Solutions National Program Office. Chronic conditions: making the case for ongoing care. Baltimore: Johns Hopkins University; 2004.Google Scholar
  185. Patir A, Seymen F, Yildirim M, Deeley K, et al. Enamel formation genes are associated with high caries experience in Turkish children. Caries Res. 2008;42(5):394–400.PubMedCrossRefGoogle Scholar
  186. Poage GM, Christensen BC, Houseman EA, McClean MD, et al. Genetic and epigenetic somatic alterations in head and neck squamous cell carcinomas are globally coordinated but not locally targeted. PLoS One. 2010;5(3):e9651.PubMedCrossRefGoogle Scholar
  187. Pokholok DK, Harbison CT, Levine S, Cole M, et al. Genome-wide map of nucleosome acetylation and methylation in yeast. Cell. 2005;122:517–27.PubMedCrossRefGoogle Scholar
  188. Polverini P. The Ann Arbor dental deans forum: crafting a response to the emerging tiered system of dental education global. Health Nexus, College of Dentistry, New York University Summer 2010 Vol. 12, No. 2. 2010.Google Scholar
  189. Rabinowitz HK, Diamond JJ, Markham FW, Wortman JR. Medical school programs to increase the rural physician supply: a systematic review and projected impact of widespread replication. Acad Med. 2008;83:235–43.PubMedCrossRefGoogle Scholar
  190. Rao NV, Rao GV, Hoidal JR. Human dipeptidyl-peptidase I. J Biol Chem. 1997;272:10260–5.PubMedCrossRefGoogle Scholar
  191. Ram S, Teruel A, Kumar SK, Clark G. Clinical characteristics and diagnosis of atypical odontalgia: implications for dentists. J Am Dent Assoc. 2009;140(2):223–8.PubMedGoogle Scholar
  192. Rassoulzadegan M, Grandjean V, Gounon P, Vincent S, et al. RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse. Nature. 2006;441:469–74.PubMedCrossRefGoogle Scholar
  193. Redman D, Jones M, Rangan B, Reimold R, Mikuls T, Amdur R, et al. Association of periodontitis with rheumatoid arthritis: a pilot study. J Periodontol. 2010;81(2):223–30.PubMedCrossRefGoogle Scholar
  194. Ren B, Robert F, Wyrick JJ, Aparicio O, et al. Genome-wide location and function of DNA binding proteins. Science. 2000;290:2306–9.PubMedCrossRefGoogle Scholar
  195. Reshetin VP, Regens JL. Simulation modeling of anthrax spore dispersion in a bioterrorism incident. Risk Anal. 2003;23(6):1135–45.PubMedCrossRefGoogle Scholar
  196. Rhodes PR. The computer-based oral health record. J Dent Educ. 1996;60(1):14–8.PubMedGoogle Scholar
  197. Rioux JD, Xavier RJ, Taylor KD, Silverberg MS, et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet. 2007;39:596–604.PubMedCrossRefGoogle Scholar
  198. Ripa LW. A half-century of community water fluoridation in the United States: review and commentary. J Public Health Dent. 1993;53(1):17–44.PubMedCrossRefGoogle Scholar
  199. Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science. 1996;273(5281):1516–7.PubMedCrossRefGoogle Scholar
  200. Robert Wood Johnson Foundation Pipeline Study. Evaluation of pipeline, profession and practice: community-based dental education. 2007. http://www.rwjf.org/pr/product.jsp?id=15455. Accessed 26 June 2011.
  201. Rodriguez-Lozano FJ, Sanchez-Perez A, Moya-Villaescusa MJ, Rodriguez-Lozano A, Saez-Yuguero MR. Neuropathic orofacial pain after dental implant placement: review of the literature and case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109(4):e8–12.PubMedCrossRefGoogle Scholar
  202. Rosenblum Jr R. Oral hygiene can reduce the incidence of and death resulting from pneumonia and respiratory tract infection. J Am Dent Assoc. 2010;141(9):1117–8.PubMedGoogle Scholar
  203. Rothwell PM, Fowkes FG, Belch JF, Ogawa H, et al. Effect of daily asprin on long-term risk of death due to cancer: analysis of individual patient data from randomized trails. Lancet. 2010;377(9759):31–41.PubMedCrossRefGoogle Scholar
  204. Rubenstein H. Access to oral health care for elders: mere words or action? J Dent Educ. 2005;69(9):1051–8.Google Scholar
  205. Ryan ME. Reconnecting the head to the body. Dental considerations for the optimal medical management of people with diabetes. Seattle: Institute for Oral Health; 2007. p. 15–7.Google Scholar
  206. Safrany E, Melegh B. Functional variants of the interleukin-23 receptor gene in non-gastrointestinal autoimmune diseases. Curr Med Chem. 2009;16(28):3766–74.PubMedCrossRefGoogle Scholar
  207. Saiki RK, Scharf S, Faloona F, Mullis KB, et al. Enzymatic amplification of β-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science. 1985;230:1350–4.PubMedCrossRefGoogle Scholar
  208. Saikku P, Leinonen M, Mattila K, Ekman MR, et al. Serological evidence of an association of a novel Chlamydia, TWAR, with chronic coronary heart disease and acute myocardial infarction. Lancet. 1988;2(8618):983–6.PubMedCrossRefGoogle Scholar
  209. Saito I, Miyamura T, Ohbayashi A, Harada H, et al. Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc Natl Acad Sci USA. 1990;87(17):6547–9.PubMedCrossRefGoogle Scholar
  210. Saito T, Shimazaki Y, Kiyohara Y, Kato I, Kubo M, Lida M, et al. The severity of periodontal disease is associated with the element of glucose intolerance in non-diabetics. J Dent Res. 2004;83:485.PubMedCrossRefGoogle Scholar
  211. Salyer KE, Xu H, Portnof JE, Yamada A, Chong DK, Genecov ER. Skeletal facial balance and harmony in the cleft patient: principles and techniques in orthognathic surgery. Indian J Plast Surg. 2009;42(Suppl):S149–67.PubMedCrossRefGoogle Scholar
  212. Saremi A, Nelson R, Tulloch-Reid M. Periodontal disease and mortality in type 2 diabetes. Diabetes Care. 2005;28:27–32.PubMedCrossRefGoogle Scholar
  213. Scannapieco FA. Pneumonia in nonambulatory patients. J Am Dent Assoc. 2006;137(2):21S–5.PubMedGoogle Scholar
  214. Schaefer AS, Richter GM, Groessner-Schreiber B, Noack B, et al. Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis. PLoS Genet. 2009;5(2):e1000378.PubMedCrossRefGoogle Scholar
  215. Schaefer AS, Richter GM, Nothnagel M, Manke T, et al. A genome-wide association study identifies GLT6D1 as a susceptibility locus for periodontitis. Hum Mol Genet. 2010;19(3):553–62.PubMedCrossRefGoogle Scholar
  216. Schleyer TK. Integrating dental office technology – the next frontier. Dent Abstr. 2003;48(3):112–3.Google Scholar
  217. Schleyer T, Eisner J. The computer-based oral health record: an essential tool for cross-provider quality management. J Calif Dent Assoc. 1997;22(11):57–64.Google Scholar
  218. Schleyer TK, Spallek H, Bartling WC, Corby P. The technologically well-equipped dental office. J Am Dent Assoc. 2003;134(1):30–41.PubMedGoogle Scholar
  219. Schleyer TK, Thyvalikakath TP, Spallek H, Torres-Urquidy MH, Hernandez P, Yuhaniak J. Clinical computing in general dentistry. J Am Med Inform Assoc. 2006a;13(3):344–52.PubMedCrossRefGoogle Scholar
  220. Schlotterer C. The evolution of molecular markers – just a matter of fashion? Nat Rev Genet. 2004;5:63–70.PubMedCrossRefGoogle Scholar
  221. Sebat J, Lakshmi B, Malhotra D, Troge J, et al. Strong association of de novo copy number mutations with autism. Science. 2007;316(5823):445–9.PubMedCrossRefGoogle Scholar
  222. Seddon JM, Reynolds R, Maller J, Fagerness JA, et al. Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables. Invest Opthalmol Vis Sci. 2008;50(5):2044–53.CrossRefGoogle Scholar
  223. Sfikas PM. HIPAA security regulations protecting patients’ electronic health information. J Am Dent Assoc. 2003;134:640–3.PubMedGoogle Scholar
  224. Sharrett AR, Hubbard LD, Cooper LS, Sorlie PD, Brothers RJ, Nieto FJ, Pinsky JL, Klein R. Retinal arteriolar diameters and elevated blood pressure: the atherosclerosis risk in communities study. Am J Epidemiol. 1999;150:263–70.PubMedGoogle Scholar
  225. Simpson TC, Needleman I, Wild SH, Moles DR, Mills EJ. Treatment of periodontal disease for glycaemic control in people with diabetes. Cochrane Database Syst Rev. 2010;12(5):CD004714.Google Scholar
  226. Slade G, Ghezzi E, Heiss G, Beck J, Riche E, Offenbacher S. Relationship between periodontal disease and C-reactive protein among adults in the atherosclerosis risk in communities study. Arch Intern Med. 2003;163:1172–9.PubMedCrossRefGoogle Scholar
  227. Social Security and Medicare Boards of Trustees. Actuarial Publications, Status of the Social Security and Medicare Programs: A Summary of the 2011 Annual Reports. http://www.ssa.gov/oact/trsum/index.html. Accessed 25 Sept. 2011.PubMedCrossRefGoogle Scholar
  228. Song YL, Wang CN, Fan MW, Su B, Bian Z. Dentin phosphoprotein frameshift mutations in hereditary dentin disorders and their variation patterns in normal human populations. J Med Genet. 2008;45:457–64.PubMedCrossRefGoogle Scholar
  229. Speliotes EK, Massaro JM, Hoffmann U, Vasan RS, et al. Fatty liver is associated with dyslipidemia and dysglycemia independent of visceral fat: the Framingham heart study. Hepatology. 2010;51(6):1979–87.PubMedCrossRefGoogle Scholar
  230. Spencer CJ, Neubert JK, Gremillion H, Zakrzewska JM, Ohrbach R. Toothache or trigeminal neuralgia: treatment dilemmas. J Pain. 2008;9(9):767–70.PubMedCrossRefGoogle Scholar
  231. Stark PC, Kalenderian E, White JM, Walji MF, Stewart DCL, Kimmes N, Meng Jr TR, Willis GP, DeVries T, Chapman RJ. Consortium for oral health-related informatics: improving dental research, education, and treatment. J Dent Educ. 2010a;74:1051–65.PubMedGoogle Scholar
  232. Stefansson H, Rujescu D, Cichon S, Pietilainen OPH, et al. Large recurrent microdeletions associated with schizophrenia. Nature. 2008;455:232–6.PubMedCrossRefGoogle Scholar
  233. Steinbacher DM, Glick M. The dental patient with asthma: an update and oral health considerations. J Am Dent Assoc. 2001;132:1229–39.PubMedGoogle Scholar
  234. Stewart JE, Wager KA, Friedlander AH, Zadeh HH. The effect of periodontal treatment on glycemic control in patients with type 2 diabetes mellitus. J Clin Periodontol. 2001;28:306–10.PubMedCrossRefGoogle Scholar
  235. Swartz K. Projected costs of chronic disease. Health care cost monitor. 2011. http://healthcarecostmonitor.thehastingscenter.org/kimberlyswartz/projected-costs-of-chronic-diseases/. loose lind Accessed 25 June 2011.
  236. Szekely DG, Milam S, Khademi JA. Legal issues of the electronic dental record: security and confidentiality. J Dent Educ. 1996;60(1):19–23.PubMedGoogle Scholar
  237. The International HapMap 3 Consortium. Integrating common and rare genetic variation in diverse human populations. Nature. 2010;467:52–8.CrossRefGoogle Scholar
  238. The National Electronic Disease Surveillance System Working Group. National Electronic Disease Surveillance System (NEDSS): a standards-based approach to connect public health and clinical medicine. J Public Health Manag Pract. 2001;7(6):42–50.Google Scholar
  239. The Pew Center on the States. Help wanted: a policy maker’s guide to new dental providers. National Academy for State Health Policy, WK Kellogg Foundation. 2009. http://www.pewcenteronthestates.org/uploadedFiles/Dental_Report_final_Low%20Res.pdf. Accessed 26 June 2011.
  240. Thorpe K, Ogden L, Galactionova K. Chronic conditions account for rise in Medicare spending from 1987 to 2006. Health Aff. 2010;29(4):718–25.CrossRefGoogle Scholar
  241. Thorstensson H, Kuylensteima J, Hugoson A. Medical status and complications in relation to periodontal disease experience in insulin-dependent diabetics. J Clin Periodontol. 1996;23:194–202.PubMedCrossRefGoogle Scholar
  242. Toomes C, James J, Wood AJ WUCL, et al. Loos-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis. Nat Genet. 1999;23(4):421–4.PubMedCrossRefGoogle Scholar
  243. Torres-Urquidy MH, Wallstrom G, Schleyer TK. Detection of disease outbreaks by the use of oral manifestations. J Dent Res. 2009;88(1):89–94.PubMedCrossRefGoogle Scholar
  244. Tsui FC, Espino JU, Dato VM, Gesteland PH, Hutman J, Wagner MM. Technical description of RODS: a real-time public health surveillance system. J Am Med Inform Assoc. 2003;10(5):399–408.PubMedCrossRefGoogle Scholar
  245. U.S. Department of Health and Human Services. Oral health in American; surgeon general’s call to action. Rockville: USDHHS, National Institute of Dental and Craniofacial Research, Nation Institutes of Health; 2003.Google Scholar
  246. Uemura N, Okamoto S, Yamamoto S, Matsumura N, et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 2001;345:784–9.PubMedCrossRefGoogle Scholar
  247. UnitedHealth Center for Health Reform & Modernization. The United States of diabetes: challenges and opportunities in the decade ahead. Minnetonka: UnitedHealth Group; 2010.Google Scholar
  248. US Census Bureau. Statistical abstract of the US. Washington, D.C.: US Government Printing Office; 2011.Google Scholar
  249. US Department of Health and Human Services. Healthy people 2020. 2010. http://www.healthypeople.gov/2020/topicsobjectives2020/pdfs/HP2020objectives.pdf. Accessed 26 June 2011.
  250. Valachovic R. Opportunities abound for new dental schools. How will we seize them? American dental education association charting progress. 2009. http://www.adea.org/about_adea/Documents/Charting%20Progress/ADEAs_Charting_Progress_August_2009.htm. Accessed 26 June 2011.
  251. Valachovic R. Holding ourselves to the highest standard: doing what’s best for patients. American dental education association charting progress. 2010. http://www.adea.org/about_adea/Documents/Charting%20Progress/ADEAs_Charting_Progress_October_2010.htm. Accessed 26 June 2011.
  252. van Houte J. Role of micro-organisms in caries etiology. J Dent Res. 1994;73(3):672–81.PubMedGoogle Scholar
  253. Venter JC, Adams MD, Myers EW, Li PW, et al. The sequence of the human genome. Science. 2001;291(5507):1304–51.PubMedCrossRefGoogle Scholar
  254. Vieira AR, Marazita ML, Goldstein-McHenry T. Genome-wide scan find suggestive caries loci. J Dent Res. 2008;87:435–9.PubMedCrossRefGoogle Scholar
  255. Visscher PM, Hill WG, Wray NR. Heritability in the genomics era – concepts and misconceptions. Nat Rev Genet. 2008;9:255–66.PubMedCrossRefGoogle Scholar
  256. Wagner MM, Moore AW, Aryel RM. Handbook of biosurveillance. Burlington: Elsevier Academic Press; 2006a.Google Scholar
  257. Walboomers JMM, Jacobs MV, Manos MM, Bosch FX, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 1999;189:12–9.PubMedCrossRefGoogle Scholar
  258. Wangsrimongkol T, Jansawang W. The assessment of treatment outcome by evaluation of dental arch relationships in cleft lip/palate. J Med Assoc Thai. 2010;93 Suppl 4:S100–6.PubMedGoogle Scholar
  259. Watson C, Alp NJ. Role of Chlamydia pneumoniae in atherosclerosis. Clin Sci. 2008;114:509–31.PubMedCrossRefGoogle Scholar
  260. Weber JL, May PE. Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. Am J Hum Genet. 1989;44:388–96.PubMedGoogle Scholar
  261. Weiss R, Dziura J, Burgert TS, Tamborlane WV, et al. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med. 2004;350(23):2362–74.PubMedCrossRefGoogle Scholar
  262. Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007;447(7145):661–78.CrossRefGoogle Scholar
  263. Werther W, Chu L, Holekamp N, Do D, Rubio R. Myocardial infarction and cerebrovascular accident in patients with retinal vein occlusion. Arch Ophthalmol. 2011;129:326–31.PubMedCrossRefGoogle Scholar
  264. White House Office of the Press Secretary. Fact sheet project bioshield. 2003. URL: http://web.archive.org/web/20090116121142/, http://www.whitehouse.gov/news/releases/2003/02/print/20030203.html. Accessed: May 2011.
  265. White JM, Kalenderian E, Stark PC, Ramoni RL, Vaderhobli R, Walji MF. Evaluating a dental diagnostic terminology in an electronic health record. J Dent Educ. 2011;75:605–15.PubMedGoogle Scholar
  266. Wiegand A, Buchalla W, Attin T. Review on fluoride-releasing restorative materials – fluoride release and uptake characteristics, antibacterial activity and influence on caries formation. Dent Mater. 2007;23(3):343–62.PubMedCrossRefGoogle Scholar
  267. Wolff A, Waldman B, Milano M, Perlman S. Dental students’ experiences with and attitudes toward people with mental retardation. J Am Dent Assoc. 2004;135:353–7.PubMedGoogle Scholar
  268. Wong TY, McIntosh R. Hypertensive retinopathy signs as risk indicators of cardiovascular morbidity and morality. Br Med Bull. 2005;73/74:57–70.CrossRefGoogle Scholar
  269. Wong TY, Klein R, Couper DJ, Cooper LS, Shahar E, Hubbard LD, Wofford MR, Sharrett AR. Retinal microvascular abnormalities and incident stroke: the atherosclerosis risk in communities study. Lancet. 2001;258:1134–40.CrossRefGoogle Scholar
  270. Wong TY, Hubbard LD, Klein R, Marino EK, Kronmal R, Sharrett AR, Siscovick DS, Burke G, Tielsch JM. Retinal microvascular abnormalities and blood pressure in older people: the cardiovascular health study. Br J Ophthalmol. 2002a;86:1007–13.PubMedCrossRefGoogle Scholar
  271. Wong TY, Klein R, Sharrett AR, Schmidt MI, Pankow JS, Couper DJ, Klein BE, Hubbard LD, Duncan BB. Retinal arteriolar narrowing and risk of diabetes in middle-aged persons. JAMA. 2002b;287:2528–33.PubMedCrossRefGoogle Scholar
  272. Wong TY, Klein R, Nieto FJ, Klein BE, Sharrett AR, Meuer SM, Hubbard LD, Tielsch JM. Retinal microvascular abnormalities and ten-year cardiovascular abnormality: a population-based case-control study. Ophthalmology. 2003a;110:933–40.PubMedCrossRefGoogle Scholar
  273. Wong WK, Moore A, Cooper G, Wagner M. WSARE: What’s strange about recent events? J Urban Health. 2003b;80(2 Suppl 1):i66–75.PubMedGoogle Scholar
  274. Wong TY, Rosamund W, Chang PP, Couper DJ, Sharrett AR, Hubbard LD, Folsom AR, Klein R. Retinopathy and risk of congestive heart failure. JAMA. 2005a;293:63–9.PubMedCrossRefGoogle Scholar
  275. Wong TY, Shankar A, Klein R, Klein BEK, Hubbard LD. Retinal arteriolar narrowing, hypertension and subsequent risk of diabetes mellitus. Arch Intern Med. 2005b;165:1060–5.PubMedCrossRefGoogle Scholar
  276. Wu T, Trevisan M, Genco R, Dorn J, Falkner K, Sempos C. Periodontal disease and risk of cerebrovascular disease. Arch Intern Med. 2000;160:2749–56.PubMedCrossRefGoogle Scholar
  277. Yelin E, Cisternas M, Foreman A, Pasta D, Centers for Disease Control and Prevention (CDC). National and state medical expenditures and lost earnings attributable to arthritis and other rheumatic conditions – United States, 2003. MMWR Morb Mortal Wkly Rep. 2007;56(1):4–7.Google Scholar
  278. Zackrisson AL, Lindblom B, Ahlner J. High frequency of occurrence of CYP2D6 gene duplication/multiduplication indicating ultrarapid metabolism along suicide cases. Clin Pharmacol Ther. 2010;88:354–9.PubMedCrossRefGoogle Scholar
  279. Zhang J. The digital pioneer. The Wall Street Journal. 2009. http://online.wsj.com/article/SB10001424052970204488304574428750133812262.html. Accessed 26 June 2011.
  280. Zhang Y, Syed R, Uygar C, Pallos D, et al. Evaluation of human leukocyte N-formylpeptide receptor (FPR1) SNPs in aggressive periodontitis patients. Genes Immun. 2003;4:22–9.PubMedCrossRefGoogle Scholar

Integration of Pediatric Medical and Pediatric Dental Care

  1. Acs G, Shulman R, Ng MW, Chussid S. The effect of dental rehabilitation on the body weight of children with early childhood caries. Pediatr Dent. 1999;21:109–13.PubMedGoogle Scholar
  2. American Academy of Pediatrics Bright Futures Guidelines. 2008. http://brightfutures.aap.org/pdfs/AAP%20Bright%20Futures%20Periodicity%20Sched%20101107.pdf Accessed 7 June 2011.
  3. American Academy of Pediatrics. Recommendations for preventive pediatric health care (periodicity schedule). 2008. http://practice.aap.org/content.aspx?aid=1599 Accessed 28 June 2011.
  4. American Academy of Pediatric Dentistry. Dental care for your baby. 2011. http://www.aapd.org/publications/brochures/babycare.asp. Accessed 28 June 2011.
  5. Broadbent JM, Thomson WM, Williams SM. Does caries in primary teeth predict enamel defects in permanent teeth? A Longitudinal Study. J Dent Res. 2005. doi: 10.1177/154405910508400310.
  6. California Dental Association. Oral health during pregnancy and early childhood: evidence-based guidelines for health professionals. Sacramento: California Dental Association; 2010.Google Scholar
  7. Casamassimo PS, Thikkurissy S, Edelstein BL, Maiorini E. Beyond the dmft: the human and economic cost of early childhood caries. J Am Dent Assoc. 2009;140(6):650–7.PubMedGoogle Scholar
  8. Caspary G, Krol DM, Boulter S, Keels MA, Romano-Clarke G. Perceptions of oral health training and attitudes toward performing oral health screenings among graduating pediatric residents. Pediatrics. 2008;122(2):e465–71.PubMedCrossRefGoogle Scholar
  9. Catalanotto F. Role of the medical team in preventing early childhood caries. 2010. http://allkids.mediasite.com/mediasite/Viewer/?peid=bab7ac16fa624951b3d1a4f604fc92c0. Accessed 5 Feb 2011.
  10. CDC. Centers for disease control and prevention. Vital and health statistics. Series 10, No. 244. 2008. http://www.cdc.gov/nchs/data/series/sr_10/sr10_244.pdf. Accessed 17 Jul 2011.
  11. Census Bureau (2010) Census Bureau quick facts. (2010). http://quickfacts.census.gov/qfd/states/00000.html. Accessed 17 Jul 2011.
  12. Dye B, Thornton-Evans G. Trends in oral health by poverty status as measured by HP 2010 objectives. Public Health Rep. 2010;125(6):817–30.PubMedGoogle Scholar
  13. Edelstein BL, Chinn CH. Update on disparities in oral health and access to dental care for America’s children. Acad Pediatr. 2009;9(6):415–9.PubMedCrossRefGoogle Scholar
  14. Ezer MS, Swoboda NA, Farkouh DR. Early childhood caries: the dental disease of infants. Oral Hlth J. 2010; 1–7.Google Scholar
  15. Ferullo A, Silk H, Savageau JA. Teaching oral health in U.S. Medical Schools: results of a national survey. Acad Med. 2010;86(2):226–30.CrossRefGoogle Scholar
  16. Fiks AG, Alessandrini EA, Forrest CB, Khan S, Localio AR, Gerber A. Electronic medical record use in pediatric primary care. J Am Med Inform Assoc. 2011. doi: 10.1136/jamia.2010.004135.
  17. Han YW, Fardini Y, Chen C, Iacampo KG, Peraino VA, Shamonki JM, et al. Term stillbirth caused by oral fusobacterium nucleatum. Obstet Gynecol. 2010;115(2):442–5.PubMedCrossRefGoogle Scholar
  18. Heuer S. Integrated medical and dental health in primary care. J Spec Pediatr Nurs. 2007;12(1):61–5.PubMedGoogle Scholar
  19. IOM (Institute of Medicine). Advancing oral health in America. Washington, D.C.: The National Academies Press; 2011a.Google Scholar
  20. IOM (Institute of Medicine). Improving access to oral health care for vulnerable and underserved populations. Washington, D.C.: The National Academies Press; 2011b.Google Scholar
  21. Lannon CM, Flower K, Duncan P, Moore KS, Stuart J. The bright futures training project: implementing systems to support preventive and developmental services in practice. Pediatrics. 2008. doi: 10.1542/peds.2007-2700.
  22. Lewis CW. Dental care and children with special health care needs: a population-based perspective. Acad Pediatr. 2009;9(6):420–6.PubMedCrossRefGoogle Scholar
  23. Lewis C, Johnston B, Linsenmeyer K, Williams A, Mouradian W. Preventive dental care for children in the US: a national perspective. Pediatrics. 2007;119:E544–53.PubMedCrossRefGoogle Scholar
  24. Lewis CW, Boulter S, Keels MA, Krol DM, Mouradian WE, O’Connor KG, et al. Oral health and pediatricians: results of a national survey. Acad Pediatr. 2009;9(6):457–61.PubMedCrossRefGoogle Scholar
  25. Li Y, Wang W. Predicting caries in permanent teeth from caries in primary teeth: an eight-year cohort study. J Dent Res. 2002;81(8):561–6. http://jdr.sagepub.com/content/81/8/561.full.pdf Accessed 17 Jul 2011.PubMedCrossRefGoogle Scholar
  26. Mabry CC, Mosca NG. Interprofessional educational partnerships in school health for children with special oral health needs. J Dent Educ. 2006;70(8):844–50.PubMedGoogle Scholar
  27. Marrs J, Trumbley S, Malik G. Early childhood caries: determining the risk factors and assessing the prevention strategies for nursing intervention. Pediatr Nurs. 2011;37(1):9–15.PubMedGoogle Scholar
  28. Mertz E, Mouradian W. Addressing children’s oral health in the new millennium: trends in the dental workforce. Acad Pediatr. 2009;9(6):443–9.CrossRefGoogle Scholar
  29. Mouradian W. Making decisions for children. Angle Orthod. 1999;69(4):300–5.PubMedGoogle Scholar
  30. Mouradian WE, Wehr E, Crall JJ. Disparities in children’s oral health and access to dental care. J Am Med Assoc. 2000;284(20):2625–31.CrossRefGoogle Scholar
  31. Mouradian W, Slayton R, Maas W, Kleinman DV, Slavkin H, DePaola D, et al. Executive summary: progress in children’s oral health since the 2000 surgeon general’s report. Acad Pediatr. 2009;9(6):374–9.PubMedCrossRefGoogle Scholar
  32. Nash DA. Adding dental therapists to the health care team to improve access to oral health care for children. Acad Pediatr. 2009;9(6):446–51.PubMedCrossRefGoogle Scholar
  33. New York State Department of Health. Oral health care during pregnancy and childhood. 2006. Available at: http://www.health.state.ny.us/publications/0824.pdf.
  34. Otto M. For want of a dentist. 2007. Washington Post, February 28, B01.Google Scholar
  35. Ramos-Gomez FJ, Shepherd DS. Cost-effectiveness model for the prevention of early childhood caries. J Calif Dent Assoc. 1999;1999:1–11.Google Scholar
  36. Ressler-Maerlender J, Krishna R, Robison V. Oral health during pregnancy: current research at the Division of Oral Health, Centers for Disease Control and Prevention. J Womens Health. 2005. doi: 10.1089/jwh.2005.14.880.
  37. Savage MF, Lee JY, Kotch JB, Vann Jr WF. Early preventive dental visits: effects on subsequent utilization and costs. Pediatrics. 2004. doi: 10.1542/peds.2003-0469-F.
  38. Seale N, McWhorter A, Mouradian W. Dental education’s role in improving children’s oral health and access to care. Acad Pediatr. 2009;9(6):440–5.PubMedCrossRefGoogle Scholar
  39. Wolfe JD, Weber-Gasparoni JD, Kane MJ, Qian F. Survey of Iowa general dentists regarding the age 1 dental visit. Pediatr Dent. 2006;28(4):325–31.PubMedGoogle Scholar

Integration of Patient Records and Clinical Research: Lack of Integration as a Barrier to Needed Research; Integration as a Prerequisite to Research

  1. Atkinson JC, Zeller GG, Shah C. Electronic patient records for dental school clinics: more than paperless systems. J Dent Educ. 2002;66(5):634–42.PubMedGoogle Scholar
  2. Barasch A, Cunha-Cruz J, Curro FA, Hujoel P, Sung AH, Vena D, et al. Risk factors for osteonecrosis of the jaws: a case–control study from the CONDOR dental PBRN. J Dent Res. 2011;90(4):439–44.PubMedCrossRefGoogle Scholar
  3. Blumenthal D, Tavenner M. The “meaningful use” regulation for electronic health records. N Engl J Med. 2010;363(6):501–4.PubMedCrossRefGoogle Scholar
  4. Brown EG, Wood L, Wood S. The medical dictionary for regulatory activities (MedDRA). Drug Saf. 1999;20(2):109–17.PubMedCrossRefGoogle Scholar
  5. Buntin MB, Burke MF, Hoaglin MC, Blumenthal D. The benefits of health information technology: a review of the recent literature shows predominantly positive results. Health Aff (Millwood). 2011;30(3):464–71.CrossRefGoogle Scholar
  6. Chambers S, Spence J, Taylor D, Walji M, Valenza JA. Assessing user perceptions of an electronic patient record (EPR) before implementation. AMIA Annu Symp Proc. 2007;2007:896.Google Scholar
  7. Chute CG, Cohn SP, Campbell KE, Oliver DE, Campbell JR. The content coverage of clinical classifications. For the computer-based patient record Institute’s Work Group on codes & structures. J Am Med Inform Assoc. 1996;3(3):224–33.PubMedCrossRefGoogle Scholar
  8. Cimino JJ. From data to knowledge through concept-oriented terminologies: experience with the Medical Entities Dictionary. J Am Med Inform Assoc. 2000;7(3):288–97.PubMedCrossRefGoogle Scholar
  9. Congressional Budget Office. Research on the comparative effectiveness of medical treatments: issues and options for an expanded federal role Pub. No. 2975. 2007. http://www.cbo.gov/ftpdocs/88xx/doc8891/12-18-ComparativeEffectiveness.pdf. Accessed 10 June 2011.
  10. Day S, Fayers P, Harvey D. Double data entry: what value, what price? Control Clin Trials. 1998;19(1):15–24.PubMedCrossRefGoogle Scholar
  11. Deshmukh VG, Meystre SM, Mitchell JA. Evaluating the informatics for integrating biology and the bedside system for clinical research. BMC Med Res Methodol. 2009;9:70.PubMedCrossRefGoogle Scholar
  12. El Emam K, Jonker E, Sampson M, Krleza-Jeric K, Neisa A. The use of electronic data capture tools in clinical trials: web-survey of 259 Canadian trials. J Med Internet Res. 2009;11(1):e8.PubMedCrossRefGoogle Scholar
  13. Fellows JL, Rindal DB, Barasch A, Gullion CM, Rush W, Pihlstrom DJ, et al. ONJ in Two dental practice-based research network regions. J Dent Res. 2011;90(4):433–8.PubMedCrossRefGoogle Scholar
  14. Goldberg LJ, Ceusters W, Eisner J, Smith B. The significance of SNODENT. Stud Health Technol Inform. 2005;116:737–42.PubMedGoogle Scholar
  15. Grabowski H, Vernon J, DiMasi JA. Returns on research and development for 1990s new drug introductions. Pharmacoeconomics. 2002;20 Suppl 3:11–29.PubMedCrossRefGoogle Scholar
  16. Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)–a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377–81.PubMedCrossRefGoogle Scholar
  17. Hosking JD, Newhouse MM, Bagniewska A, Hawkins BS. Data collection and transcription. Control Clin Trials. 1995;16(2 Suppl):66S–103S.PubMedCrossRefGoogle Scholar
  18. Kalenderian E, Ramoni RL, White JM, Schoonheim-Klein ME, Stark PC, Kimmes NS, et al. The development of a dental diagnostic terminology. J Dent Educ. 2010;75(1):68–76.Google Scholar
  19. King DW, Lashley R. A quantifiable alternative to double data entry. Control Clin Trials. 2000;21(2):94–102.PubMedCrossRefGoogle Scholar
  20. Kleinman K. Adaptive double data entry: a probabilistic tool for choosing which forms to reenter. Control Clin Trials. 2001;22(1):2–12.PubMedCrossRefGoogle Scholar
  21. Langabeer 2nd JR, Walji MF, Taylor D, Valenza JA. Economic outcomes of a dental electronic patient record. J Dent Educ. 2008;72(10):1189–200.PubMedGoogle Scholar
  22. Manheimer E, Anderson D. Survey of public information about ongoing clinical trials funded by industry: evaluation of completeness and accessibility. BMJ. 2002;325(7363):528–31.PubMedCrossRefGoogle Scholar
  23. McCray AT. Better access to information about clinical trials. Ann Intern Med. 2000;133(8):609–14.PubMedGoogle Scholar
  24. Rondel RKVS, Webb CF. Clinical data management. 2nd ed. Chichester: Wileys; 2000.Google Scholar
  25. Schleyer TK, Thyvalikakath TP, Spallek H, Torres-Urquidy MH, Hernandez P, Yuhaniak J. Clinical computing in general dentistry. J Am Med Inform Assoc. 2006b;13(3):344–52.PubMedCrossRefGoogle Scholar
  26. Singer SW, Meinert CL. Format-independent data collection forms. Control Clin Trials. 1995;16(6):363–76.PubMedCrossRefGoogle Scholar
  27. Spence J, Valenza JA, Taylor D. Documentation of clinical workflow: a key step in a plan to facilitate implementation of an electronic patient record. AMIA Annu Symp Proc. 2007;2007:1119.Google Scholar
  28. Stark PC, Kalenderian E, White JM, Walji MF, Stewart DC, Kimmes N, et al. Consortium for oral health-related informatics: improving dental research, education, and treatment. J Dent Educ. 2010b;74(10):1051–65.PubMedGoogle Scholar
  29. Strang N, Cucherat M, Boissel JP. Which coding system for therapeutic information in evidence-based medicine. Comput Methods Programs Biomed. 2002;68(1):73–85.PubMedCrossRefGoogle Scholar
  30. Taylor D, Valenza JA, Spence JM, Baber RH. Integrating electronic patient records into a multi-media clinic-based simulation center using a PC blade platform: a foundation for a new pedagogy in dentistry. AMIA Annu Symp Proc. 2007;2007:1129.Google Scholar
  31. Valenza JA, Walji M. Creating a searchable digital dental radiograph repository for patient care, teaching and research using an online photo management and sharing application. AMIA Annu Symp Proc. 2007;2007:1143.Google Scholar
  32. Walji M, Loeffelholz J, Valenza JA. A human-centered design of a dental discharge summary (DDS) for patients. AMIA Annu Symp Proc. 2007;2007:1146.Google Scholar
  33. Walji MF, Taylor D, Langabeer 2nd JR, Valenza JA. Factors influencing implementation and outcomes of a dental electronic patient record system. J Dent Educ. 2009;73(5):589–600.PubMedGoogle Scholar
  34. Zelenski S, Hood H, Holder M. Continuum of Quality Care Series, American Academy of Developmental Medicine and Dentistry. 2008. http://aadmd.org/articles/medicine-i-introduction. Accessed 15 May 2011PubMedGoogle Scholar

Copyright information

© Springer-Verlag London Limited 2012

Authors and Affiliations

  • Stephen Foreman
    • 1
  • Joseph Kilsdonk
    • 2
  • Kelly Boggs
    • 2
  • Wendy E. Mouradian
    • 19
  • Suzanne Boulter
    • 20
  • Paul Casamassimo
    • 3
    • 4
  • Valerie J. H. Powell
    • 21
  • Beth Piraino
    • 5
  • Wells Shoemaker
    • 6
  • Jessica Kovarik
    • 8
  • Evan(Jake) Waxman
    • 7
  • Biju Cheriyan
    • 9
  • Henry Hood
    • 10
    • 11
  • Allan G. Farman
    • 12
  • Matthew Holder
    • 11
    • 13
  • Miguel Humberto Torres-Urquidy
    • 14
  • Muhammad F. Walji
    • 15
  • Amit Acharya
    • 16
  • Andrea Mahnke
    • 16
  • Po-Huang Chyou
    • 16
  • Franklin M. Din
    • 17
  • Steven J. Schrodi
    • 18
  1. 1.Health EconomicsRobert Morris UniversityPittsburghUSA
  2. 2.Division of EducationMarshfield ClinicMarshfieldUSA
  3. 3.Division of Pediatric DentistryThe Ohio State University College of DentistryColumbusUSA
  4. 4.Center for Clinical and Translational ResearchNationwide Children’s HospitalColumbusUSA
  5. 5.Renal Division, Department of MedicineUniversity of Pittsburgh Medical SchoolPittsburghUSA
  6. 6.California Association of Physician GroupsSacramentoUSA
  7. 7.Department of OphthalmologyUniversity of PittsburghPittsburghUSA
  8. 8.School of MedicineUniversity of PittsburghPittsburghUSA
  9. 9.Holy Cross Hospital, Kottiyam and Caritas HospitalKottiyamIndia
  10. 10.Department of Orthodontic, Pediatric and Geriatric DentistryUniversity of Louisville School of DentistryLouisvilleUSA
  11. 11.Underwood and Lee ClinicLouisvilleUSA
  12. 12.Department of Surgical and Hospital DentistryUniversity of Louisville School of DentistryLouisvilleUSA
  13. 13.American Academy of Developmental Medicine and DentistryLouisvilleUSA
  14. 14.Department of Biomedical InformaticsUniversity of PittsburghPittsburghUSA
  15. 15.Dental BranchUniversity of TexasHoustonUSA
  16. 16.Biomedical Informatics Research CenterMarshfield Clinic Research FoundationMarshfieldUSA
  17. 17.HP Enterprise ServicesGlobal HealthcareCamp HillUSA
  18. 18.Center for Human GeneticsMarshfield Clinic Research FoundationMarshfieldUSA
  19. 19.Department of Pediatric Dentistry, Schools of Dentistry, Medicine and Public HealthUniversity of WashingtonSeattleUSA
  20. 20.Department of PediatricsDartmouth Medical SchoolHanoverUSA
  21. 21.Department of Computer and Information Systems, Clinical Data Integration ProjectRobert Morris UniversityMoon TownshipUSA

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