Normal Bone

  • Peter A. Revell
Chapter

Abstract

The components of the skeleton may be divided into broad categories for general descriptive purposes. The long or tubular bones have a shaft of compact bone surrounding a central cavity which contains cancellous bone together with bone marrow and fat. The cortical bone is thickest in the mid-portion of the shaft, while the cancellous bone is relatively diminished in amount in this region, being more pronounced in density towards the bone ends. The tubular bones comprise the long tubular bones of the limbs (humerus, radius, ulna, femur, tibia and fibula) and the short tubular bones in the hands and feet (metacarpals, metatarsals and phalanges).

Keywords

Growth Plate Collagen Fibril Amorphous Calcium Phosphate Matrix Vesicle Epiphyseal Plate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Ali SY (1976) Analysis of matrix vesicles and their role in the calcification of epiphyseal cartilage. Fed Proc 35:135–142PubMedGoogle Scholar
  2. Ali SY, Sajdera SW, Anderson HC (1970) Isolation and characterization of calcifying matrix vesicles from epiphyseal cartilage. Proc Natl Acad Sci USA 67: 1513–1520PubMedCrossRefGoogle Scholar
  3. Ali SY, Wisby A, Gray JC (1978) Electron probe analysis of cryosections of epiphyseal cartilage. Metab Bone Dis Relat Res 1:97–103CrossRefGoogle Scholar
  4. Amstutz HC, Sissons HA (1969) The structure of the vertebral spongiosa. J Bone Joint Surg [Br] 51:540–550Google Scholar
  5. Anderson HC (1967) Electron microscopic studies of induced cartilage development and calcification. J Cell Biol 35: 81–101PubMedCrossRefGoogle Scholar
  6. Anderson HC (1969) Vesicles associated with calcification in the matrix of epiphyseal cartilage. J Cell Biol 41:59–72PubMedCrossRefGoogle Scholar
  7. Anderson HC (1976) Matrix vesicle calcification. Introduction. Fed Proc 35:105–108Google Scholar
  8. Ash P, Loutit JF, Townsend KMS (1980) Osteoclasts derived from haemopoietic stem cells. Nature 283: 669–670PubMedCrossRefGoogle Scholar
  9. Athanasou NA, Gray A, Revell PA, Fuller K, Cochrane T, Chambers TJ (1984) Steriophotogrammetric observations on bone resorption by isolated rabbit osteoclasts. Micron Microscopia Acta 15:47–53CrossRefGoogle Scholar
  10. Bachra BN (1970) Calcification of connective tissue. Int Rev Connect Tissue Res 5:165–208PubMedGoogle Scholar
  11. Bassett CAL (1968) Biologic significance of piezoelectricity. Calcif Tissue Res 1: 252–272PubMedCrossRefGoogle Scholar
  12. Baud CA (1976) Osteocyte, osteocytic functions and morphometry of periosteocytic lacunae. In: Meunier PJ (ed) Bone histomorphometry. 2nd international workshop. Armour Montagu, Paris, pp 429–432.Google Scholar
  13. Baud CA, Auil E (1971) Osteocyte differential count in normal human alveolar bone. Acta Anat 78:321–327PubMedCrossRefGoogle Scholar
  14. Baylink DJ, Wergedal JE (1971) Bone formation by osteocytes. Am J Physiol 221: 669–678PubMedGoogle Scholar
  15. Belanger LF (1969) Osteocytic osteolysis. Calcif Tissue Res 4:1–12PubMedCrossRefGoogle Scholar
  16. Betts F, Blumenthal NC, Posner AS, Becker GL, Lehringer AL (1975) The atomic structure of intercellular amorphous calcium phosphate deposits. Proc Natl Acad Sci USA 72:2088–2090PubMedCrossRefGoogle Scholar
  17. Bonucci E (1967) Fine structure of early cartilage calcification. J Ultrastruct Res 20: 33–50PubMedCrossRefGoogle Scholar
  18. Bonucci E (1981) New knowledge on the origin, function and fate of osteoclasts. Clin Orthop 158: 252–269PubMedGoogle Scholar
  19. Bordier Ph J, Marie P, Miravet L, Ryckewaert A, Rasmussen H (1976) Morphological and morphometrical characteristics of the mineralisation front. A vitamin D regulated sequence of the bone remodeling. In: Meunier PJ (ed) Bone histomorphometry. 2nd international workshop. Armour Montagu, Paris, pp 335–354Google Scholar
  20. Borle AB (1967) Membrane transfer of calcium. Clin Orthop Relat Res 52: 267–291PubMedCrossRefGoogle Scholar
  21. Boskey AL (1978) The role of calcium-phospholipid-phosphate complexes in tissue mineralisation. Metab Bone Dis Relat Res 1:137–142CrossRefGoogle Scholar
  22. Boskey AL, Posner AS (1977) The role of synthetic and bone extracted Ca-phospholipid-PO4 complexes in hydroxyapatite formation. Calcif Tissue Res 23:251–258PubMedCrossRefGoogle Scholar
  23. Boyde A (1972) Scanning electron microscope studies of bone. In: Bourne GH (ed) The biochemistry and physiology of bone, 2nd edn, vol 1. Academic, New York, pp 259–310Google Scholar
  24. Boyde A (1981) Evidence against ‘osteocytic osteolysis’. In: Jee WSS, Parfitt AM (eds) Bone histomorphometry. 3rd international workshop. Metab Bone Dis Relat Res 2 (Suppl): 239–255Google Scholar
  25. Brighton CT (1978) Structure and function of the growth plate. Clin Orthop 136:22–32PubMedGoogle Scholar
  26. Brighton CT, Hunt RM (1974) Mitochondrial calcium and its role in calcification. Histochemical localisation of calcium in electron micrographs of the epiphyseal growth plate with K-pyroantimonate. Clin Orthop 100:406–416PubMedCrossRefGoogle Scholar
  27. Brighton CT, Hunt RM (1976) Histochemical localization of calcium in growth plate mitochondria and matrix vesicles. Fed Proc 35:143–147PubMedGoogle Scholar
  28. Brighton CT, Ray RD, Soble LW, Kuettner KE (1969) In vitro epiphyseal-plate growth in various oxygen tensions. J Bone Joint Surg [Am] 51: 1383–1396Google Scholar
  29. Brighton CT, Sugioka Y, Hunt RM (1973) Cytoplasmic structures of the epiphyseal-plate chondrocytes. Quantitative evaluation using electron micrographs of rat costochondral junctions with special reference to the fate of hypertrophic cells. J Bone Joint Surg [Am] 55: 771–784Google Scholar
  30. Cameron DA, Robinson RA (1958) The presence of crystals in the cytoplasm of large cells adjacent to sites of bone resorption. J Bone Joint Surg [Am] 40:414–418Google Scholar
  31. Cecil RNA, Anderson HC (1978) Freeze-fracture studies of matrix vesicle calcification in epiphyseal growth plate. Metab Bone Dis Relat Res 1:89–95CrossRefGoogle Scholar
  32. Chambers TJ (1980) The cellular basis of bone resorption. Clin Orthop 151: 283–293PubMedGoogle Scholar
  33. Chambers TJ, Revell PA, Fuller K, Athanasou NA (1984) Resorption of bone by isolated rabbit osteoclasts. J Cell Sci 66: 383–399PubMedGoogle Scholar
  34. Chung SMK, Batterman SC, Brighton CT (1976) Shear strength of the human femoral capital epiphyseal plate. J Bone Joint Surg [Am] 58:94–103Google Scholar
  35. Courpron P, Lepine P, Arlet M, Lips P, Meunier PJ (1980) Mechanisms underlying the reduction in age of the mean wall thickness of trabecular basic structure unit (BSU) of human iliac bone. In: Jee WSS, Parfitt AM (eds) Bone histomorphometry. 3rd international workshop. Metab Bone Dis Relat Res 2 (Suppl): 323–329Google Scholar
  36. Dudley RH, Spiro D (1961) The fine structure of bone cells. J Biophys Biochem Cytol 11: 627–671PubMedCrossRefGoogle Scholar
  37. Ellis HA (1981) Metabolic bone disease. In: Anthony PP, MacSween RNM (eds) Recent advances in histopathology, vol 11. Churchill Livingstone, Edinburgh, pp 185–202Google Scholar
  38. Enlow DH, Conklin JL (1964) A study of lipid distribution in compact bone. Anat Res 148:279Google Scholar
  39. Fleisch H, Bisaz S (1962) Mechanism of calcification: Inhibitory role of pyrophosphate. Nature 195:911PubMedCrossRefGoogle Scholar
  40. Friedenstein AJ (1976) Precursors of mechanocytes. Int Rev Cytol 47: 327–359PubMedCrossRefGoogle Scholar
  41. Friedenstein AJ, Petrakova KU, Kurolesova AI, Frolova GP (1968) Heterotopic transplants of bone marrow-analysis of precursor cells of osteogenic and hematopoietic tissues. Transplantation 6:230–246PubMedCrossRefGoogle Scholar
  42. Friedenstein AJ, Chailakhjan RK, Lalykina KS (1970) The development of fibroblast colonies in monolayer cultures of guinea pig bone marrow and spleen cells. Cell Tissue Kinet 3: 393–402PubMedGoogle Scholar
  43. Frost HM (1964) Dynamics of bone remodelling. In: Frost HM (ed) Bone biodynamics. Little, Brown, Boston, pp 315–333Google Scholar
  44. Frost HM (1976) A method of analysis of trabecular bone dynamics. In: Meunier PJ (ed) Bone histomorphometry. 2nd international workshop. Armour Montague, Paris, pp 445–476Google Scholar
  45. Glauert A, Mayo CR (1973) The study of three dimensional structure relationships in connective tissues by high voltage electron microscopy. J Microsc 97: 83–94PubMedCrossRefGoogle Scholar
  46. Glimcher MJ (1976) Composition, structure, and organization of bone and other mineralized tissues and the mechanism of calcification. In: Aurbach GD (ed) Handbook of physiology-Endocrinology VII. Williams and Wilkins, Baltimore, pp 25–116Google Scholar
  47. Gonzales F, Karnovsky MJ (1961) Electron microscopy of osteoclasts in healing fractures of rat bone. J Biophys Biochem Cytol 9: 299–316PubMedCrossRefGoogle Scholar
  48. Hancox NM (1972) Biological structure and function. No. 1. In: Harrison RJ, McMinn RMH (eds) Biology of bone. Cambridge University Press, CambridgeGoogle Scholar
  49. Harris WH, Haywood EA, Lavorgna J, Hamblen DL (1968) Spatial and temporal variations in cortical bone formation in dogs. J Bone Joint Surg [Am] 50: 1118–1128Google Scholar
  50. Heersche JNM (1978) Mechanism of osteoclastic bone resorption: a new hypothesis. Calcif Tissue Res 26:81–84PubMedCrossRefGoogle Scholar
  51. Hodge AJ, Petraska JA (1963) Recent studies with the electron microscope on ordered aggregates of the tropocollagen macromolecule. In: Ramachandran GN (ed) Aspects of protein structure. Academic, New York, pp 289–300Google Scholar
  52. Holtrop ME (1972) The ultrastructure of the epiphyseal plate. II The hypertrophic chondrocyte. Calcif Tissue Res 9:140–151PubMedCrossRefGoogle Scholar
  53. Holtrop ME (1976) Quantitation of the ultrastructure of the osteoclast for the evaluation of cell function. In: Meunier PJ (ed) Bone histomorphometry. 2nd international workshop. Armour Montagu, Paris, pp 133–145Google Scholar
  54. Irving JT (1963) The sudanophilic material in the early stages of calcification. Arch Oral Biol 8:735–745PubMedCrossRefGoogle Scholar
  55. Irving JT, Wuthier RE (1968) Histochemistry and biochemistry of calcification with special reference to the role of lipids. Clin Orthop 56:237–260PubMedGoogle Scholar
  56. Jande SS, Belanger LF (1973) The life cycle of the osteocyte. Clin Orthop 94:281–305PubMedGoogle Scholar
  57. Jowsey J, Kelley PJ, Riggs BL, Bianco AJ, Scholz DA, Gershon-Cohen J (1965) Quantitative microradiographic studies of normal and osteoporotic bone. J Bone Joint Surg [Am] 47: 785–806Google Scholar
  58. Kahn AJ, Stewart CC, Teitelbaum SL (1978) Contact-mediated bone resorption by human monocytes in vitro. Science 199:988–990PubMedCrossRefGoogle Scholar
  59. Kashiwa HK, Homorous J (1971) Mineralised spherules in the cells and matrix of calcifying cartilage from developing bone. Anat Res 170: 119–128CrossRefGoogle Scholar
  60. Katchburian E (1973) Membrane-bound bodies as initiators of mineralization of dentine. J Anat 116: 285–302PubMedGoogle Scholar
  61. Katz EP, Li S-T (1973a) The intermolecular space of reconstituted collagen fibrils. J Mol Biol 73: 351–369PubMedCrossRefGoogle Scholar
  62. Katz EP, Li S-T (1973b) Structure and function of bone collagen fibrils. J Mol Biol 80:1–15PubMedCrossRefGoogle Scholar
  63. Kember NF (1960) Cell division in endochondral ossification; a study of cell proliferation in rat bones by the method of tritiated thymidine autoradiography. J Bone Joint Surg [Br] 42: 824–839Google Scholar
  64. Kuhlman RE (1960) A microchemical study of the developing epiphyseal plate. J Bone Joint Surg [Am] 42:457–466Google Scholar
  65. Kuhlman RE (1965) Phosphatases in epiphyseal cartilage-their possible role in tissue synthesis. J Bone Joint Surg [Am] 47: 545–550Google Scholar
  66. Lee SL, Glimcher MJ (1981) Purification, composition and 31PNMR spectroscopic properties of a noncolla- genous phosphoprotein isolated from chicken bone matrix. Calcif Tissue Int 33: 385–394PubMedCrossRefGoogle Scholar
  67. Lehninger AL (1970) Mitochondria and calcium transport. Biochem J 119:129–138PubMedGoogle Scholar
  68. Loutit JF, Nisbet NW (1979) Resorption of bone. Lancet II: 26–29PubMedCrossRefGoogle Scholar
  69. Marks SC (1983) The origin of osteoclasts: evidence, clinical implications and investigative challenges of an extra-skeletal source. J Pathol 12:226–256Google Scholar
  70. Martin JH, Matthews JL (1969) Mitochondrial granules in chondrocytes. Calcif Tissue Res 3:184–193PubMedCrossRefGoogle Scholar
  71. Martin JH, Matthews JL (1970) Mitochondrial granules in chondrocytes, osteoblasts and osteocytes. Clin Orthop 68:273–278PubMedGoogle Scholar
  72. Matsuzawa T, Anderson HC (1971) Phosphatases of epiphyseal cartilage studied by electron microscopic cytochemical methods. J Histochem Cytochem 19: 801–808PubMedCrossRefGoogle Scholar
  73. Milch RA, Hall DP, Tobie JE (1958) Fluorescence of tetracycline antibiotics in bone. J Bone Joint Surg [Am] 40: 897–910Google Scholar
  74. Miller A, Wray TS (1971) Molecular packing in collagen. Nature 230:437–439PubMedCrossRefGoogle Scholar
  75. Mundy CR, Altman AJ, Gondek MD, Bandelin JG (1977) Direct resorption of bone by human monocytes. Science 196:1109–1111PubMedCrossRefGoogle Scholar
  76. Mundy CR, Varani J, Orr W, Gondek MD, Ward PA (1978) Resorbing bone is chemotactic for monocytes. Nature 275:132–135PubMedCrossRefGoogle Scholar
  77. Nogemi H, Oohira A (1984) Postnatal new bone formation. Clin Orthop 184:106–113Google Scholar
  78. Odutaga AA, Prout RES (1974) Lipid analysis of human enamel and dentine. Arch Oral Biol 19: 729–731CrossRefGoogle Scholar
  79. Owen M (1970) The origin of bone cells. Int Rev Cytol 28:215–238Google Scholar
  80. Owen M (1980) The origin of bone cells in the postnatal organism. Arthritis Rheum 23:1073–1079PubMedCrossRefGoogle Scholar
  81. Owen M (1983) Bone cell differentiation. In: Dixon AStJ, Russell RGG, Stamp TCB (eds) Osteoporosis. A multidisciplinary problem. Royal Society of Medicine International Congress and Symposium Series, No 55. Academic Press and Royal Society of Medicine, London, 25–29Google Scholar
  82. Parfitt AM (1976) The actions of parathyroid hormone on bone: relation to bone remodelling and turnover, calcium homeostasis and metabolic bone disease. Metabolism 25: 809–844PubMedCrossRefGoogle Scholar
  83. Parfitt AM (1982) The coupling of bone formation to bone resorption: a critical analysis of the concept and of its relevance to the pathogenesis of osteoporosis. Metab Bone Dis Relat Res 4:1–6PubMedCrossRefGoogle Scholar
  84. Parfitt AM, Villanueva AR, Crouch MM, Mathews CHE, Duncan M (1976) Classification of osteoid seams by combined use of cell morphology and tetracycline labelling. Evidence for intermittency of mineralization. In: Meunier PJ (ed) Bone histomorphometry. 2nd international workshop. Armour Montagu, Paris, pp 299–310Google Scholar
  85. Peress NS, Anderson HC, Sajdera SW (1974) The lipids of matrix vesicles from bovine fetal epiphyseal cartilage. Calcif Tissue Res 14: 275–282PubMedCrossRefGoogle Scholar
  86. Posner AS, Betts F, Blumenthal NC (1978) Properties of nucleating systems. Metab Bone Dis Relat Res 1:179–183CrossRefGoogle Scholar
  87. Price PA, Baukol SA (1981) 1,25 dihydroxyvitamin D3 increases serum levels of the vitamin-K dependant bone protein. Biochem Biophys Res Commun 99: 928–935PubMedCrossRefGoogle Scholar
  88. Price PA, Parthemore JG, Deftos LJ (1980) New biochemical marker for bone metabolism: measurement by radioimmunoassay of bone GLA protein in the plasma of normal subjects and patients with bone disease. J Clin Invest 66: 878–883PubMedCrossRefGoogle Scholar
  89. Pritchard JJ (1952) A cytological and histochemical study of bone and cartilage formation in the rat. J Anat 86:259–277PubMedGoogle Scholar
  90. Rabinowitch AL, Anderson HC (1976) Biogenesis of matrix vesicles in cartilage growth plates. Fed Proc 35:112–116Google Scholar
  91. Raisz LG (1976) Mechanisms of bone resorption. In: Aurbach GD (ed) Handbook of physiology- Endocrinology VII. Parathyroid gland. Williams and Wilkins, Baltimore, pp 117–136Google Scholar
  92. Raisz LG, Kream BE (1983a) Regulation of bone formation. N Engl J Med 309:29–35PubMedCrossRefGoogle Scholar
  93. Raisz LG, Kream BE (1983b) Regulation of bone formation. N Engl J Med 309:83–89PubMedCrossRefGoogle Scholar
  94. Rasmussen J, Bordier P (1974) Bone cells-morphology and physiology. In: The physiology and cellular basis of metabolic bone disease. Williams and Wilkins, Baltimore, pp 9–69Google Scholar
  95. Russell RGG, Kanis JA, Gowen M, Gallagher JA, Beresford J, Guilland-Cumming D, Coulton LA, Preston CJ, Brown BL, Sharrard M, Beard DJ (1983) Cellular control of bone formation and repair. In: Dixon AStJ, Russell RGG, Stamp TCB (eds) Osteoporosis. A multidisciplinary problem. Royal Society Medicine International Congress and Symposium Series No 55. Academic Press and Royal Society of Medicine, London, pp 31–42Google Scholar
  96. Sayegh FS, Solomon GC, Davis RW (1974) Ultrastructure of intracellular mineralization in the deer’s antler. Clin Orthop 99:267–284PubMedCrossRefGoogle Scholar
  97. Schenk RK, Merz WA, Muller J (1969) A quantitative histological study on bone resorption in human cancellous bone. Acta Anat 74:44–53PubMedCrossRefGoogle Scholar
  98. Scott BL, Pease DC (1956) Electron microscopy of the epiphyseal apparatus. Anat Rec 126:465–495PubMedCrossRefGoogle Scholar
  99. Shapiro F, Holtrop ME, Glimcher MJ (1977) Organisation and cellular biology of the perichondrial ossification groove of Ranvier. J Bone Joint Surg [Am] 59: 703–723Google Scholar
  100. Shapiro IM (1970) The association of phospholipids with anorganic bone. Calcif Tissue Res 5:13–20PubMedCrossRefGoogle Scholar
  101. Shapiro IM, Burke A, Lee NH (1976) Heterogeneity of chondrocyte mitochondria. A study of the Ca2+ concentration and density banding characteristics of normal and rachitic cartilage. Biochim Biophys Acta 451: 583–591PubMedCrossRefGoogle Scholar
  102. Silberman M, Frommer J (1974) Initial locus of calcification in chondrocytes. Clin Orthop 98:288–293CrossRefGoogle Scholar
  103. Spycher MA, Moore H, Ruettner JR (1969) Electron microscopic investigations on aging and osteoarthritic human articular cartilage. Z Mikrosk Anat Forsch 98: 512–524CrossRefGoogle Scholar
  104. Sutfin LV, Holtrop ME, Ogilvie RE (1971) Microanalysis of individual mitochondrial granules with diameters less than 1,000 angstroms. Science 174: 947–949PubMedCrossRefGoogle Scholar
  105. Teitelbaum SL, Nichols SH (1976) Tetracycline-based morphometric analysis of trabecular bone kinetics. In: Meunier PJ (ed) Bone histomorphometry. 2nd international workshop. Armour Montagu, Paris, pp 311–319Google Scholar
  106. Teitelbaum SL, Stewart CC, Kahn AJ (1979) Rodent peritoneal macrophages as bone resorbing cells. Calcif Tissue Int 27: 255–261PubMedCrossRefGoogle Scholar
  107. Termine JD, Conn KM (1976) Inhibition of apatite formation by phosphorylated metabolites and macromolecules. Calcif Tissue Res 22:149–157PubMedCrossRefGoogle Scholar
  108. Termine JD, Kleinmann HK, Whitson SW, Conn KM, McGarvey ML, Martin GR (1981) Osteonectin, a bone-specific protein linking mineral to collagen. Cell 26:99–105PubMedCrossRefGoogle Scholar
  109. Thyberg J, Friberg U (1972) Electron microscopic enzyme histochemical studies on the cellular genesis of matrix vesicles in epiphyseal plate. J Ultrastruct Res 41:43–59PubMedCrossRefGoogle Scholar
  110. Tonna EA (1961) The cellular complement of the skeletal system studied autoradiographically with tritiated thymidine (H3TDR) during growth and aging. J Biophys Biomed Cytol 9: 813–824CrossRefGoogle Scholar
  111. Urist MR (1981) New bone formation induced in post fetal life by bone morphogenetic protein. In: Becker RA (ed) Mechanisms of growth control. Thomas, Springfield, Ill, pp 406–434Google Scholar
  112. Urist MR, Mikulski AJ (1979) A soluble morphogenetic protein extracted from bone matrix with a mixed aqueous and nonaqueous solvent. Proc Soc Exp Biol Med 162:48–53PubMedGoogle Scholar
  113. Urist MR, Nakagawa M, Nakata N, Nogemi H (1978) Experimental myositis ossificans: cartilage and bone formation in muscle in response to a diffusible bone matrix-derived morphogen. Arch Pathol Lab Med 102: 312–316PubMedGoogle Scholar
  114. Urist MR, Lietze A, Mizutani H, Takagi K, Triffitt JT, Amstatz J, De Lange R, Termine J, Finerman GAM (1982) A bovine low molecular weight bone morphogenetic protein (BMP) fraction. Clin Orthop 162:219–232PubMedGoogle Scholar
  115. Vittali P (1968) Osteocytic activity. Clin Orthop 56: 213–226PubMedGoogle Scholar
  116. Vogel JJ, Boyan-Salyers BD (1976) Acidic lipids associated with the local mechanism of calcification, a review. Clin Orthop 118: 230–241Google Scholar
  117. Vogel JJ, Boyan-Salyers B, Campbell MM (1978) Protein-phospholipid interactions in biologic calcification. Metab Bone Dis Relat Res 1:149–153CrossRefGoogle Scholar
  118. Walker DG (1975) Bone resorption restored in osteopetrotic mice by transplants of normal bone marrow and spleen cells. Science 190: 784–785PubMedCrossRefGoogle Scholar
  119. Wuthier RE (1968) Lipids of mineralizing epiphyseal tissues in the bovine fetus. J Lipid Res 9: 68–78PubMedGoogle Scholar
  120. Wuthier RE (1976) Lipids of matrix vesicles. Fed Proc 35:117–121PubMedGoogle Scholar
  121. Yoneda T, Mundy GR (1979a) Prostaglandins are necessary for osteoclast activating factor production by activated peripheral blood leukocytes. J Exp Med 149:279–283PubMedCrossRefGoogle Scholar
  122. Yoneda T, Mundy GR (1979b) Monocytes regulate osteoclast activating factor production by releasing prostaglandins. J Exp Med 150: 338–350PubMedCrossRefGoogle Scholar
  123. Young RW (1962) Cell proliferation and specialization during endochondral osteogenesis in the rat. J Cell Biol 14:357–370PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Peter A. Revell
    • 1
  1. 1.Institute of Pathology, The London Hospital, Bone and Joint Research UnitThe London Hospital Medical CollegeWhitechapelUK

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