Assessing and Treating Low Incidence/High Severity Psychological Disorders of Childhood pp 199-221 | Cite as
Childhood Onset Schizophrenia
Chapter
First Online:
Abstract
Although it is a relatively rare disorder, childhood onset schizophrenia (COS) can have devastating effects for the affected individual. The disorder permeates every aspect of a child’s life and poor prognosis is associated with diagnoses made before the age of 10 years. Although the exact cause of the disorder is unknown, there are studies to suggest that prenatal insult combined with later environmental factors contribute to the development of schizophrenia. This chapter reviews the etiological hypotheses, diagnostic criteria, and treatment options for children diagnosed with COS.
Keywords
American Psychiatric Association Negative Symptom Psychotic Symptom Antipsychotic Medication Positive Symptom
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
- Addington, A. M., Gornick, M. C., Shaw, P., Seal, J., Gogtay, N., Greenstein, D., et al. (2007). Neuregulin 1 (8p12) and childhood-onset schizophrenia: Susceptibility haplotypes for diagnosis and brain developmental trajectories. Molecular Psychiatry, 12, 195–205.PubMedCrossRefGoogle Scholar
- American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed., rev.). Washington, DC: Author.Google Scholar
- American Psychiatric Association. (2010). DSM-5 development: Attenuated psychotic symptoms syndrome. Retrieved August 24, 2010, from http://www.dsm5.org/ProposedRevisions/Pages/proposedrevision.aspx?rid=412.
- Armenteros, J. L., & Davies, M. (2006). Antipsychotics in early onset schizophrenia: Systematic review and meta-analysis. European Child and Adolescent Psychiatry, 15, 141–148.PubMedCrossRefGoogle Scholar
- Armenteros, J. L., & Mikhail, A. G. (2002). Do we need placebos to evaluate new drugs in children with schizophrenia? Psychopharmacology, 159, 117–124.PubMedCrossRefGoogle Scholar
- Asarnow, J. R. (1994). Childhood-onset schizophrenia. Journal of Child Psychology and Psychiatry, 35, 1345–1371.PubMedCrossRefGoogle Scholar
- Asarnow, J. R., & Asarnow, R. F. (2003). Childhood-onset schizophrenia. In E. J. Mash & R. A. Barkley (Eds.), Child Psychopathology (2nd ed., pp. 455–485). New York, NY: The Guilford Press.Google Scholar
- Asarnow, J. R., Tompson, M. C., & Goldstein, M. J. (1994). Childhood-onset schizophrenia: A followup study. Schizophrenia Bulletin, 20, 599–617.PubMedGoogle Scholar
- Asarnow, J. R., Tompson, M. C., & McGrath, E. P. (2004). Childhood-onset schizophrenia: Clinical and treatment issues. Journal of Child Psychology and Psychiatry, 45, 180–194.PubMedCrossRefGoogle Scholar
- Auther, A. M., Gillett, D. A., & Cornblatt, B. A. (2008). Expanding the boundaries of early intervention for psychosis: Intervening during the prodrome. Psychiatric Annals, 38, 528–537.CrossRefGoogle Scholar
- Barr, C. E., Mednick, S. A., & Munk-Jorgensen, P. (1990). Exposure to influenza epidemics during gestation and adult schizophrenia. Archives of General Psychiatry, 47, 869–874.PubMedGoogle Scholar
- Bearden, C. E., Rosso, I. M., Hollister, J. M., Sanchez, L. E., Hadley, T., & Cannon, T. D. (2000). A prospective cohort study of childhood behavioral deviance and language abnormalities as predictors of adult schizophrenia. Schizophrenia Bulletin, 26, 395–410.PubMedGoogle Scholar
- Bender, L. (1941). Childhood schizophrenia. Nervous Child, 1, 138–140.Google Scholar
- Bender, L. (1958). Psychiatric problems of childhood. Medical Clinics of North America, 42, 755–767.PubMedGoogle Scholar
- Bertolino, A., Kumra, S., Callicott, J. H., Mattay, V. S., Lestz, R. M., Jacobsen, L., et al. (1998). Common pattern of cortical pathology in childhood-onset and adult-onset schizophrenia as identified by proton magnetic resonance spectroscopic imaging. American Journal of Psychiatry, 155, 1376–1383.PubMedGoogle Scholar
- Bettes, B., & Walker, E. (1987). Positive and negative symptoms in psychotic and other psychiatrically disturbed children. Journal of Child Psychology and Psychiatry, 28, 555–567.PubMedCrossRefGoogle Scholar
- Bikmaz, A. U. S. (2007). The effects of childhood trauma in patients with first-episode schizophrenia. Acta Psychiatrica Scandinavica, 116, 371–377.PubMedCrossRefGoogle Scholar
- Bleuler, E. (1911). Dementia praecox oder die Gruppe der Schizophrenien. Handbuch der Psychiatrie, Halfte 1. Leipzig: Deuticke.Google Scholar
- Brown, A. S., Begg, M. D., Gravenstein, S., Schaefer, C. A., Wyatt, R. J., Bresnahan, M. A., et al. (2004). Serological evidence for prenatal influenza in the etiology of schizophrenia. Archives of General Psychiatry, 61, 774–780.PubMedCrossRefGoogle Scholar
- Carlsson, A. (2006). The neurochemical circuitry of schizophrenia. Pharmacopsychiatry, 39, 10–14.CrossRefGoogle Scholar
- Carlsson, M. L., Carlsson, A., & Nilsson, M. (2004). Schizophrenia: From dopamine to glutamate and back. Current Medicinal Chemistry, 11, 267–277.PubMedCrossRefGoogle Scholar
- Cordero, J. F. (2003). A new look at behavioral outcomes and teratogens: A commentary. Birth Defects Research (Part A): Clinical and Molecular Teratology, 67(11), 900–902.CrossRefGoogle Scholar
- Creak, M. (1964). Schizophrenia syndrome in childhood: Further progress report of a working party. Developmental Medicine and Child Neurology, 6, 530–535.Google Scholar
- Dombrowski, S. C., & Martin, R. P. (2007). Pre and perinatal exposures in later psychological, behavioral, and cognitive disability. School Psychology Quarterly, 22, 1–7.CrossRefGoogle Scholar
- Dombrowski, S. C., & Martin, R. P. (2009). Maternal fever during pregnancy: Association with temperament, behavior and academic outcomes in children. Saarbrucken, Germany: VDM Verlag.Google Scholar
- Dombrowski, S. C., Martin, R. P., & Huttenen, M. O. (2003). Association between maternal fever and psychological/behavioral outcomes: An hypothesis. Birth Defects Research (Part A): Clinical and Molecular Teratology, 67, 905–910.CrossRefGoogle Scholar
- Doss, A. J. (2005). Evidence-based diagnosis: Incorporating diagnostic instruments into clinical practice. Journal of the American Academy of Child and Adolescent Psychiatry, 44, 947–952.PubMedCrossRefGoogle Scholar
- Dulmus, C. N., & Smyth, N. J. (2000). Early-onset schizophrenia: A literature review of empirically based interventions. Child and Adolescent Social Work Journal, 17, 55–69.CrossRefGoogle Scholar
- Eggers, C., & Bunk, D. (1997). The long-term course of childhood-onset schizophrenia: A 42-year follow up. Schizophrenia Bulletin, 23, 105–117.PubMedGoogle Scholar
- Eggers, C., Bunk, D., & Krause, D. (2000). Schizophrenia with onset before the age of eleven: Clinical characteristics of onset and course. Journal of Autism and Developmental Disorders, 30, 29–38.PubMedCrossRefGoogle Scholar
- Emminghaus, H. (1887). Die psychischen Storungen des Kindesalters. Tubingen: Laupp.Google Scholar
- Foster, K. A., Swartz, L., & de Jager, W. (2006). The clinical presentation of childhood-onset schizophrenia: A literature review. South African Journal of Psychology, 36, 299–318.Google Scholar
- Gaebel, W., & Frommann, N. (2000). Long-term course in schizophrenia: Concepts, methods and research strategies. Acta Psychiatrica Scandinavica, 102, 49–53.CrossRefGoogle Scholar
- Gaspar, P. A., Bustamante, M. L., Silva, H., & Aboitiz, F. (2009). Molecular mechanisms underlying glutamatergic dysfunction in schizophrenia: Therapeutic implications. Journal of Neurochemistry, 111, 891–900.PubMedCrossRefGoogle Scholar
- Gonthier, M., & Lyon, M. A. (2004). Childhood-onset schizophrenia: An overview. Psychology in the Schools, 41, 803–811.CrossRefGoogle Scholar
- Green, W., Padron-Gayol, M., Hardesty, A. S., & Bassiri, M. (1992). Schizophrenia with childhood onset: A phenomenological study of 38 cases. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 968–976.CrossRefGoogle Scholar
- Hall, S. D., & Bean, R. A. (2008). Family therapy and childhood-onset schizophrenia: Pursuing clinical and bio/psycho/social competence. Contemporary Family Therapy, 30, 61–74.CrossRefGoogle Scholar
- Hans, S. L., Auerbach, J. G., Styr, B., & Marcus, J. (2004). Offspring of parents with schizophrenia: Mental disorders during childhood and adolescence. Schizophrenia Bulletin, 30, 303–315.PubMedGoogle Scholar
- Harrison, P. J., & Weinberger, D. R. (2005). Schizophrenia genes, gene expression, and neuropathology: On the matter of their convergence. Molecular Psychiatry, 10, 40–68.PubMedCrossRefGoogle Scholar
- Helling, I., Öhman, A., & Hultman, C. M. (2003). School achievements and schizophrenia: A case-control study. Acta Psychiatrica Scandinavica, 108, 381–386.PubMedCrossRefGoogle Scholar
- Hollis, C. (2003). Developmental precursors of child- and adolescent-onset schizophrenia and affective psychoses: Diagnostic specificity and continuity with symptom dimensions. British Journal of Psychiatry, 182, 37–44.PubMedCrossRefGoogle Scholar
- Homburger, A. (1926). Vorlesungen uber psychopathologie des kindesalters. Berlin: Springer.Google Scholar
- Husted, J. A., Greenwood, C. M. T., & Bassett, A. S. (2006). Heritability of schizophrenia and major affective disorder as a function of age, in the presence of strong cohort effects. European Archives of Psychiatry and Clinical Neuroscience, 256, 222–229.PubMedCrossRefGoogle Scholar
- Jacobsen, L. K., & Rapoport, J. L. (1998). Research update: Childhood-onset schizophrenia: Implications of clinical and neurobiological research. Journal of Child Psychology and Psychiatry, 39, 101–113.PubMedCrossRefGoogle Scholar
- Jahshan, C., Heaton, R. K., Golshan, S., & Cadenhead, K. S. (2010). Course of neurocognitive deficits in the prodrome and first episode of schizophrenia. Neuropsychology, 24, 109–120.PubMedCrossRefGoogle Scholar
- Kendler, K. S., & Tsuang, M. T. (1981). Nosology of paranoid schizophrenia and other paranoid psychoses. Schizophrenia Bulletin, 7, 594–610.PubMedGoogle Scholar
- Kestenbaum, C. J. (1980). Children at risk for schizophrenia. American Journal of Psychotherapy, 2, 164–177.Google Scholar
- King, S., Laplante, D., & Joober, R. (2005). Understanding putative risk factors for schizophrenia: Retrospective and prospective studies. Review of Psychiatric Neuroscience, 30, 342–348.Google Scholar
- Kraepelin, E. (1896). Psychiatrie: Ein Lehrbuch fur Studirende und Aerzte. Leipzig, East Germany: Ambrosius Barth.Google Scholar
- Kraepelin, E. (1919). Dementia Praecox and Paraphrenia. Edinburgh: E&S Livingstone.Google Scholar
- Ledda, M. G., Fratta, A. L., Pintor, M., Zuddas, A., & Cianchetti, C. (2009). Early on-set psychoses: Comparison of clinical features and adult outcome in 3 diagnostic groups. Child Psychiatry and Human Development, 40, 421–437.PubMedCrossRefGoogle Scholar
- Leonhard, K. (1986). Aufteilung der endogenen Psychosen und ihre differenzierte Ätiologie (2nd ed.). Berlin, Germany: Akademie-Verlag.Google Scholar
- Machon, R. A., Mednick, S. A., & Huttenen, M. O. (1997). Adult major affective disorder after prenatal exposure to an influenza epidemic. Archives of General Psychiatry, 54, 322–328.PubMedGoogle Scholar
- Martin, R. P., & Dombrowski, S. C. (2008). Prenatal exposures: Psychological and educational consequences for children. New York, NY: Springer.Google Scholar
- Masi, G., Mucci, M., & Pari, C. (2006). Children with schizophrenia: Clinical picture and pharmacological treatment. CNS Drugs, 20, 841–866.PubMedCrossRefGoogle Scholar
- McClellan, J., & McCurry, C. (1998). Neurocognitive pathways in the development of schizophrenia. Seminars in Clinical Neuropsychiatry, 3, 320–332.PubMedGoogle Scholar
- McClellan, J., & McCurry, C. (1999). Early onset psychotic disorders: Diagnostic stability and clinical characteristics. European Child and Adolescent Psychiatry, 8(Suppl. 1), I/13–I/19.Google Scholar
- McClellan, J. M., Werry, J. S., & Ham, M. (1993). A follow-up study of early onset psychosis: Comparison between outcome diagnoses of schizophrenia, mood disorders and personality disorders. Journal of Autism and Developmental Disorders, 23, 243–262.PubMedCrossRefGoogle Scholar
- McClellan, J., Werry, J., & The Workgroup on Quality Issues. (2001). Practice parameter for the assessment and treatment of children and adolescents with schizophrenia. Journal of the American Academy of Child and Adolescent, 40(7), 4S–23S.CrossRefGoogle Scholar
- McDonnell, M. G., & McClellan, J. M. (2007). Early-onset schizophrenia. In E. J. Mash & R. A. Barkely (Eds.), Assessment of childhood disorders (4th ed., pp. 526–550). New York, NY: The Guilford Press.Google Scholar
- McGrath, J., & Castle, D. (1995). Does influenza cause schizophrenia? A five year review. Australian and New Zealand Journal of Psychiatry, 29, 23–31.PubMedCrossRefGoogle Scholar
- Mednick, S. A., Machon, R. A., Huttenen, M. O., & Bonnett, D. (1988). Adult schizophrenia following prenatal exposure to an influenza epidemic. Archives of General Psychiatry, 45, 189–192.PubMedGoogle Scholar
- Meisenzahl, E. M., Schmitt, G. J., Scheuerecker, J., & Möller, H. J. (2007). The role of dopamine for the pathophysiology of schizophrenia. International Review of Psychiatry, 19, 337–345.PubMedCrossRefGoogle Scholar
- Menninger, K. A. (1928a). Medicolegal proposals of the American Psychiatric Association. Journal of the American Institute of Criminal Law and Criminology, 19(3), 367–377.CrossRefGoogle Scholar
- Menninger, K. A. (1928b). The schizophrenic syndromes as a product of acute infectious disease. Archives of Neurology and Psychiatry, 20, 464–481.Google Scholar
- Moncrieff, J. (2009). A critique of the dopamine hypothesis of schizophrenia and psychosis. Harvard Review of Psychiatry, 17, 214–225.PubMedCrossRefGoogle Scholar
- Neumann, C. S., Grimes, K., Walker, E. F., & Baum, K. (1995). Developmental pathways to schizophrenia: Behavioral subtypes. Journal of Abnormal Psychology, 104, 558–566.PubMedCrossRefGoogle Scholar
- Patel, N. C., Crismon, M. L., Shafer, A., DeLeon, A., Lopez, M., & Lane, D. C. (2006). Ethnic variation in symptoms and response to risperidone in youths with schizophrenia-spectrum disorders. Social Psychiatry and Psychiatric Epidemiology, 41, 341–346.PubMedCrossRefGoogle Scholar
- Read, J., van Os, J., Morrison, A. P., & Ross, C. A. (2005). Childhood trauma, psychosis, and schizophrenia: A literature review with theoretical and clinical implications. Acta Psychiatrica Scandinavica, 112, 330–350.PubMedCrossRefGoogle Scholar
- Remschmidt, H. E. (2001). Schizophrenia in children and adolescents. Cambridge: Cambridge University Press.Google Scholar
- Remschmidt, H. (2008). Schizophrenia in children and adolescents. In T. Banaschewski & L. A. Rohde (Eds.), Biological child psychiatry: Recent trends and developments. Basel, Switzerland: Karger.Google Scholar
- Remschmidt, H., Fleischhaker, C., Hennighausen, K., & Schulz, E. (2000). Management of schizophrenia in children and adolescents: The role of clozapine. Paediatric Drugs, 2(4), 253–262.PubMedCrossRefGoogle Scholar
- Remschmidt, H. E., Schulz, E., Martin, M., Warnke, A., & Trott, G. (1994). Childhood-onset schizophrenia: History of the concept and recent studies. Schizophrenia Bulletin, 20, 727–745.PubMedGoogle Scholar
- Sowell, E. R., Toga, A. W., & Asarnow, R. (2000). Brain abnormalities observed in childhood-onset schizophrenia: A review of the structural magnetic resonance imaging literature. Mental Retardation and Developmental Disabilities Research Reviews, 6, 180–185.PubMedCrossRefGoogle Scholar
- Tarbox, S. I., & Pogue-Geile, M. F. (2008). Development of social functioning in preschizophrenic children and adolescents: A systematic review. Psychological Bulletin, 134(4), 561–583.PubMedCrossRefGoogle Scholar
- Thomas, M. A., Yong, K., Levitt, J., Caplan, R., Curran, J., Asarnow, R., et al. (1998). Preliminary study of frontal lobe [1H] MR spectroscopy in childhood-onset schizophrenia. Journal of Magnetic Resonance Imaging, 8, 841–846.PubMedCrossRefGoogle Scholar
- Toren, P., Ratner, S., Laor, N., & Weizman, A. (2004). Benefit-risk assessment of atypical antipsychotics in the treatment of schizophrenia and comorbid disorders in children and adolescents. Drug Safety, 27, 1135–1156.PubMedCrossRefGoogle Scholar
- Van Lieshout, R. J., & Voruganti, L. P. (2008). Diabetes mellitus during pregnancy and increased risk of schizophrenia in offspring: A review of the evidence and putative mechanisms. Journal of Psychiatry and Neuroscience, 33, 395–404.PubMedGoogle Scholar
- Waddington, J. L., O’Callaghan, E., Youssef, H. A., Buckley, P., Lane, A., Cotter, D., et al. (1999). Schizophrenia: Evidence for a “cascade” process with neurodevelopmental origins. In E. S. Susser, A. S. Brown, & J. M. Gorman (Eds.), Prenatal exposure in schizophrenia (pp. 3–34). Washington, DC: American Psychiatric Press.Google Scholar
- Werry, J. S. (1992). Child and adolescent (early onset) schizophrenia: A review in light of DSM-III-R. Journal of Autism and Developmental Disorders, 22, 601–624.PubMedCrossRefGoogle Scholar
- Werry, J. S., McClellan, J., & Chard, L. (1991). Early onset schizophrenia, bipolar and schizoaffective disorders: A clinical follow-up study. Journal of the American Academy of Child and Adolescent Psychiatry, 30, 457–465.PubMedCrossRefGoogle Scholar
- Winterer, G. (2006). Cortical microcircuits in schizophrenia: The dopamine hypothesis revisited. Pharmacopsychiatry, 39, 68–71.CrossRefGoogle Scholar
- World Health Organization (WHO). (1992). The ICD-10 classification of mental health and behavioral disorders: Clinical descriptions and diagnostic guidelines. Geneva: Author.Google Scholar
Copyright information
© Springer Science+Business Media, LLC 2011