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The Contractile and Neurohormonal Roles of Phospholamban in Heart Failure

  • Rajesh Dash
  • Evangelia G. KraniasEmail author
Part of the Progress in Experimental Cardiology book series (PREC, volume 5)

Abstract

Heart failure is a down-spiraling syndrome of neurohormonal imbalance and hemodynamic instability, in which impaired cardiac function has been linked to perturbations in subcellular calcium handling. Phospholamban (PLB) is a phosphoprotein that inhibits cardiac muscle relaxation by lowering the apparent affinity of the sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA2) for Ca2+. Major determinants of phospholamban s regulatory activity are the relative PLB/SERCA2 ratio and phospholamban’s phosphorylation status, both of which are altered in failing human hearts. PLB impairs myocardial calcium handling and observed perturbations of PLB levels and/or activity in human heart failure may contribute to depressed contractility. Therapeutic implications for PLB are intriguing, as PLB’s activity and levels are significantly influenced by specific neurohormonal systems.

Key words

Sarcoplasmic Reticulum Neuroendocrine Calcium Therapeutics 

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  1. 1.Department of Pharmacology and Cell BiophysicsUniversity of Cincinnati College of MedicineCincinnati OHUSA

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