Of Vaccination and Infectious Diseases in 2003

  • Stanley A. Plotkin
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 549)


Vaccination has entered its 3rd century, having started with the use of vaccinia virus by Jenner in the last decade of the 18th century. Pasteur put vaccination on a more empirical footing in the 1880s, and vaccine development proceeded slowly up to the mid-20th century. During this early period, live bacterial and viral vaccines were attenuated by passage in animals and we learned how to kill microbes without destroying their immunogenicity. In addition, knowledge of bacterial toxins and capsular polysaccharides permitted the development of important new vaccines for epidemic infections.


Herpes Simplex Virus Human Papilloma Virus Vaccine Development Pertussis Vaccine Rift Valley Fever 
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  1. Plotkin, S. A., 2003, May 1, Vaccines, vaccination, and vaccinology, J Infect. Dis. 187(9):1349–1359.PubMedCrossRefGoogle Scholar

Copyright information

© Science+Business Media New York 2004

Authors and Affiliations

  • Stanley A. Plotkin

There are no affiliations available

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