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Gene Therapy for the Acute Respiratory Distress Syndrome

  • Phillip Factor
Chapter
  • 145 Downloads
Part of the NATO ASI Series book series (NSSA, volume 297)

Abstract

Gene therapy has been the focus of much attention and expectation in recent years. Many conditions have been identified as being likely targets for gene therapy, most of which are either heritable disorders or cancers. Recently acquired disorders, including acute lung diseases, have been identified as potential applications for gene therapy. Gene therapy has evolved from a concept to clinical application via phase I safety studies in humans. Due to current limitations of gene transfer technology little headway has been made in terms of true impact on human disease. Principal limitations of current technology have included lack of prolonged expression of transgenic proteins at physiologically relevant levels in an adequate number of target cells. Despite these stumbling blocks, optimism for gene therapy continues due to the belief that it will create new avenues for therapies that are not currently possible or imaginable. Gene therapy research continues to thrive due to its unrealized potential and with the hope that it will some day be common place therapy for a large number of conditions.

Keywords

Nitric Oxide Gene Therapy Gene Transfer Acute Lung Injury Acute Respiratory Distress Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1998

Authors and Affiliations

  • Phillip Factor
    • 1
  1. 1.Pulmonary and Critical Care Medicine, COLUMBIA/Michael Reese HospitalUniversity of Illinois at ChicagoChicagoUSA

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