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Regulation of the Sodium Pump in Hyperoxic Lung Injury

  • David H. Ingbar
  • Joseph M. Lasnier
  • O. Douglas Wangensteen
  • Christine H. Wendt
Chapter
  • 143 Downloads
Part of the NATO ASI Series book series (NSSA, volume 297)

Abstract

A major component of the early lesion in the adult respiratory distress syndrome (ARDS) is alveolar edema. Considerable data suggests that decreasing alveolar flooding improves the outcome from acute lung injury (ALI). Studies in humans with ARDS demonstrate that prognosis correlates with the capacity to resorb fluid (Matthay 1990). Retrospective studies indicate that patients with fluid balance out>in, lesser weight gain, lower pulmonary capillary wedge pressures or diuretic treatment have greater survival rates. It is not surprising that decreasing the degree of early alveolar flood could decrease the subsequent need for high pressure ventilation or high levels of oxygen — thus avoiding amplification of the injury.

Keywords

Acute Lung Injury Alveolar Epithelial Cell Adult Respiratory Distress Syndrome Alveolar Type Keratinocyte Growth Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1998

Authors and Affiliations

  • David H. Ingbar
    • 1
  • Joseph M. Lasnier
    • 1
  • O. Douglas Wangensteen
    • 1
  • Christine H. Wendt
    • 1
  1. 1.Departments of Medicine, Physiology and PediatricsUniversity of Minnesota School of MedicineMinneapolisUSA

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